# libraries used for analysis
library(edgeR)
library(limma)
library(quadprog)
library(ruv)
# libraries required for graphics
library(ggplot2)
library(reshape2)
library(EDASeq)
library(RColorBrewer)
library(VennDiagram)
library(data.table)
library(dplyr)
library(stringr)
library(knitr)
library(pheatmap)
wd = "./"
colors <- c("#0571b0", "#ca0020")
We first produce a matrix of read counts after aligning to both the Human and Plasmodium falciparum 3D7 reference genome. Subread’s featureCounts program is then used to allocate reads to gene features using the gff file PlasmoDB-12.0_Pfalciparum3D7.gff from PlasmoDB. For both Subread programs the default options are used.
setwd(wd)
# # Next subreads featureCounts was used to allocate reads to genes. This
# was saved for re-use files <-
# Sys.glob('/home/users/allstaff/tonkin-hill.g/all_gene_analysis/alignment/*.sam')
# fc_genes_aligned_w_Pfhuman_withoutVivax <- featureCounts(files, annot.ext
# = './data/PlasmoDB-12.0_Pfalciparum3D7.gff' , isPairedEnd=TRUE,
# isGTFAnnotationFile=TRUE, GTF.attrType='ID', GTF.featureType='gene' ,
# nthreads=15)
# Load gene ID mappings which we use later on.
geneID_mappings <- fread("./data/geneID_mappings.txt", data.table = FALSE, stringsAsFactors = FALSE)
trim <- function(x) gsub("^\\s+|\\s+$", "", x)
s <- str_split(as.character(geneID_mappings$`[Previous ID(s)]`), ",")
geneID_mappings <- data.frame(current = rep(geneID_mappings$`[Gene ID]`, sapply(s,
FUN = length)), old = unlist(s))
geneID_mappings$old <- str_trim(geneID_mappings$old)
# Load read counts (if featureCounts has been run previously)
load("./data/fc_genes_with_all_samples_aligned_human_Pf_WithOutVivax_subread_uH.RData")
fc2 <- fc_genes_aligned_w_Pfhuman_withoutVivax
t <- fc2$counts
# Rename samples to something more sensible colnames(t) <-
# gsub('alignment\\.sam','',colnames(t)) colnames(t) <-
# gsub('.*vivax\\.','',colnames(t)) colnames(t) <- gsub('_S.*','',
# colnames(t))
fc2$counts <- t
x <- DGEList(counts = fc2$counts, genes = fc2$annotation)
We next filter out genes that do not have sufficient coverage across our samples for reliable estimates to be made.
setwd(wd)
before <- nrow(x$counts)
keep <- rowSums(cpm(x) > 2) >= 10
x <- x[keep, , keep.lib.sizes = FALSE]
We require that there are at least 2 reads per million for at least 10 samples in order for a gene to be included in the analysis. This reduced the number of genes being considered from 5777 to 4144.
setwd(wd)
bplot <- melt(colSums(x$counts))
colnames(bplot) <- c("Read.Counts")
bplot$Sample <- rownames(bplot)
gg <- ggplot(bplot, aes(x = factor(Sample), y = Read.Counts)) + geom_bar(stat = "identity")
gg <- gg + theme_bw() + scale_y_sqrt(breaks = c(0, 10000, 1e+06, 1e+07, 1e+08))
gg <- gg + theme(axis.text.x = element_text(size = 12, angle = 90), axis.text.y = element_text(size = 12,
angle = 0), axis.title = element_text(size = 14, face = "bold"))
gg <- gg + labs(x = "Sample", y = "Read Count")
gg <- gg + geom_hline(aes(yintercept = 1e+06), col = "red")
x$counts <- x$counts[, !grepl("SFD1|SFM9|SFC\\.025", colnames(x$counts))]
filt.annnotation <- fc2$annotation[fc2$annotation$GeneID %in% rownames(x$counts),
]
dge <- DGEList(counts = x$counts, genes = filt.annnotation)
gg
Samples SFD1, SFM9 and SFC.025 were not sequenced to a sufficient depth to be reliable and thus are removed.
Samples SFU2 and SFU3 were drug treated and are removed. We repeated the analysis of the all gene DGE omitting a few patients who had anti-malarial treatments in preceding months. The patients omitted are: SFC 023, SFM007, IFM 012 and IFM 021.
x$counts <- x$counts[, !grepl("SFU2|SFU\\.3", colnames(x$counts))]
x$counts <- x$counts[, !grepl("SFC\\.023|SFM\\.7|IFM12|IFM21", colnames(x$counts))]
filt.annnotation <- fc2$annotation[fc2$annotation$GeneID %in% rownames(x$counts),
]
dge <- DGEList(counts = x$counts, genes = filt.annnotation)
Now we take the log transform of our sample counts (RPKM) to estimate the proportion of different stages present.
setwd(wd)
our_log_rpkm <- rpkm(dge)
our_log_rpkm <- log2(1 + our_log_rpkm)
To estimate the proportion of different life-cycle stages in each of our samples we require a reference data set. Su et al provide such a reference. They performed RNA-seq at two gametocyte stages, an ookinete stage and four time points of erythrocytic stages representing ring, early trophozoite, late trophozoite, and schizont. As we do not expect any ookinete stage parasites we discarded this reference. The data was downloaded from PlasmoDB and as such read counts were reported in RPKM. To handle outlying counts in a sensible manner a log2 transformation of the RPKM values was performed. This was also done for our gene counts. By next fitting a mixture model we can estimate the proportion of different parasite stages that make up our samples.
setwd(wd)
su_rpkm <- read.csv("./data/ rpkm_7SexualAndAsexualLifeStages_suetal.csv", header = TRUE,
sep = ",")
# ignore the Ookinete profile as this should be absent from our data.
su_rpkm$Ookinete <- NULL
rownames(su_rpkm) <- su_rpkm$ID
su_rpkm$ID <- NULL
# take the log transform of the data which helps to manage outlier genes.
su_log_rpkm <- log2(1 + su_rpkm)
Given a set of stages \(S\) and a set of genes \(g_i: i\in \{1,...,N\}\) we want to minimise
\[ \sum_{i=1}^N \left( g_{i,sample} - \sum_{s \in S} \pi_s g_{i,s} \right)^2 \]
Subject to constraints
\[ \sum_{s\in S} \pi_s = 1 \]
\[ \pi_s > 0 \]
Here \(\pi_s\) is proportion of stage \(s\) that is attributed to having contributed to our sample. This model was fit using R’s solve.QP function.
setwd(wd)
findMix <- function(Y, X) {
X[is.na(X)] <- t(replicate(ncol(X), apply(X, 1, mean, na.rm = T)))[is.na(X)]
Rinv <- solve(chol(t(X) %*% X))
C <- cbind(rep(1, ncol(X)), diag(ncol(X)))
b <- c(1, rep(0, ncol(X)))
d <- t(Y) %*% X
qp <- solve.QP(Dmat = Rinv, factorized = TRUE, dvec = d, Amat = C, bvec = b,
meq = 1)
sol <- qp$solution
sol[sol < 1e-10] <- 0
return(sol)
}
We fit this mixture model to each of our samples in turn. The results are then plotted. A column represents each sample in the plot below. As we are fitting proportion parameters each columns values must add to 1 over the 5 stages. Note that we have also combined the estimated proportions for the gametocyte samples into one gametocyte variable. The columns are coloured by phenotype.
setwd(wd)
# First get the intersection of the genes for the two datasets and order
# them by rowname.
inter <- intersect(rownames(our_log_rpkm), rownames(su_log_rpkm))
O <- our_log_rpkm[rownames(our_log_rpkm) %in% inter, ]
O <- O[order(rownames(O)), ]
S <- su_log_rpkm[rownames(su_log_rpkm) %in% inter, ]
S <- S[order(rownames(S)), ]
# Now lets fit some samples!
ourPlotData <- data.frame()
for (i in 1:ncol(O)) {
mix <- findMix(O[, i], as.matrix(S))
ourPlotData <- rbind(ourPlotData, data.frame(sample = rep(colnames(O)[i],
ncol(S)), stage = colnames(S), proportion = mix))
}
# Organise the results.
ourPlotData$stage <- gsub("Gametocyte.*", "Gametocyte", ourPlotData$stage)
ourPlotData <- aggregate(proportion ~ sample + stage, data = ourPlotData, FUN = sum)
ourPlotData <- within(ourPlotData, stage <- factor(stage, levels = c("Ring",
"Early.Trophozoite", "Late.Trophozoite", "Schizont", "Gametocyte")))
ourPlotData$phenotype <- ifelse(substring(ourPlotData$sample, 1, 1) == "I",
"non-severe", "severe")
# Make a pretty plot.
gg <- ggplot(ourPlotData, aes(x = factor(sample), y = proportion, fill = factor(phenotype))) +
geom_bar(stat = "identity")
gg <- gg + scale_fill_manual(values = c(`non-severe` = "#2c7bb6", severe = "#d7191c"))
gg <- gg + facet_wrap(~stage, ncol = 1)
gg <- gg + theme_bw()
gg <- gg + theme(axis.text.x = element_text(size = 12, angle = 90), axis.text.y = element_text(size = 12,
angle = 0), axis.title = element_text(size = 14, face = "bold"), strip.text.x = element_text(size = 16,
face = "bold"))
gg <- gg + labs(x = "Sample", y = "Proportion", fill = "Stage")
gg <- gg + theme(legend.text = element_text(size = 14))
gg <- gg + theme(legend.key.size = unit(0.25, "in"))
gg <- gg + theme(legend.title = element_text(size = 16, face = "bold"))
gg <- gg + guides(fill = guide_legend(title = "Phenotype"))
gg
We now perform the Voom transformation on our count matrix. Prior to the transformation we use TMM normalisation to account for the different library sizes present in our sample. TMM was chosen as it is more robust to outliers. From the Voom variance trend it is evident that there are a number of genes that have both high variability and high expression. After looking at some of the main offenders these were identified to be influenced by staging in the parasite. Consequently it is important to account for life-cycle stage when conducting the differential expression analysis.
options(width = 150)
setwd(wd)
categories <- as.factor(substring(rownames(dge$samples), 1, 1))
dge <- calcNormFactors(dge, method = "TMM")
dge$samples$group <- categories
design <- model.matrix(~group, data = dge$samples)
v <- voom(dge, design = design, plot = TRUE)
The PCA plot below indicates that accounting for library size alone does not cope with the impact of life-cycle stages. Notably SFC21 is clearly an outlier and was identified in the mixture model as containing later stage parasites as well as gametocytes. IFM14 is also slightly separate in the PCA plot and was identified as having a proportion of Schizont stage parasite present.
setwd(wd)
plotPCA(v$E, col = colors[categories], cex = 0.8, isLog = TRUE)
Further the Relative Log Expression (RLE) plot below suggests that there is something different about SFC21 as well as highlighting IFM060 as being different.
setwd(wd)
plotVoomRLE <- function(E, colours) {
mn <- apply(E, 1, median)
rle <- data.frame(sweep(E, MARGIN = 1, STATS = mn, FUN = "-"))
boxplot(rle, col = colours, outline = FALSE, las = 2, ylim = c(-7, 7))
abline(h = 0, col = "black")
}
plotVoomRLE(v$E, colors[categories])
To investigate the impact of life-cycle stages in our analysis we fit a linear model using limma’s removeBatchEffect. Initially ring, gametocyte and schizont parameters were fit along with the disease phenotype factor. This was because for the most part the Trophozoite stages could be represented by accounting for these stages as they would be present implicitly in the model.
The PCA indicates that we have dealt with the outlying SFC21 sample as well as other less outlying samples such as IFM14 which showed a proportion of Schizont stage parasites in the mixture model. Unfortunately due to the low number of samples that have proportions of Schizont and Gametocytes estimating differential differential expression in severe disease becomes impossible. This is because there is insufficient data to estimate these stage parameters and consequently the uncertainty in the model is too high to find significant differences between severe and non-severe disease.
setwd(wd)
covs <- data.frame(v$design[, 2])
ourPlotData$phenotype <- NULL
c <- dcast(ourPlotData, sample ~ ..., value.var = "proportion")
covs <- merge(covs, c, by.x = 0, by.y = "sample")
colnames(covs) <- c("sample", "disease", colnames(c)[2:ncol(c)])
rownames(covs) <- covs$sample
covs$sample <- NULL
covs <- covs[match(colnames(v$E), rownames(covs)), ]
stopifnot(colnames(v$E) == rownames(covs))
# head(covs)
covs <- covs[, c(1, 2, 5, 6)]
# head(covs)
mod = model.matrix(as.formula(paste("~", paste(colnames(covs), collapse = " + "), sep = "")), data = covs)
norm_counts_ring <- removeBatchEffect(v$E, covariates = mod[, 3:ncol(mod)], design = mod[, 1:2])
plotPCA(norm_counts_ring, col = colors[categories], cex = 0.8, isLog = TRUE)
The RLE plot also suggests we have dealt with SFC21 however accounting for these stages does not seem to have accounted for the differences we see in the IFM060 sample. The mixture model did not identify IFM060 as being noticeably different from the other samples and consequently it is likely that there is some other unknown factor impacting on its expression.
setwd(wd)
plotVoomRLE(norm_counts_ring, col = colors[categories])
We then investigate the impact of only accounting for the Ring stage parameter in the model. This gives us more power with which to identify differential expression related to severe disease. However, from the PCA plot below it is clear that accounting for Ring stage alone is insufficient and fails to adequately deal with SFC21.
setwd(wd)
covs <- covs[, c(1, 2)]
mod = model.matrix(as.formula(paste("~", paste(colnames(covs), collapse = " + "), sep = "")), data = covs)
norm_counts_ring <- removeBatchEffect(v$E, covariates = mod[, 3:ncol(mod)], design = mod[, 1:2])
plotPCA(norm_counts_ring, col = colors[categories], cex = 0.8, isLog = TRUE)
We are however able to identify differentially expressed genes in this less parameterised model. The summary of results accounting only for the Ring stage variable are given below. This test was performed using the limma-Voom pipeline. Ideally we would be able to keep both the power in out tests and account for the remaining unwanted factors. To achieve this we make use of RUV-4 to estimate dummy variables that represent multiple unknown factors of unwanted variation.
setwd(wd)
stopifnot(colnames(dge) == rownames(mod))
v2 <- voom(dge, design = mod, plot = FALSE)
fit <- lmFit(v2, mod)
fit <- eBayes(fit, robust = TRUE)
summary(de1 <- decideTests(fit, adjust.method = "BH", p.value = 0.05))
## (Intercept) disease Ring
## -1 81 18 1265
## 0 681 4069 1734
## 1 3382 57 1145
To cope with the outlier samples such as SFC21 whilst retaining statistical power we estimate factors of unwanted variation using RUV-4.
RUV-4 requires a set of control genes which are believed to be relatively unaffected by the condition of interest, in our case this is disease severity. RUV-4 is however fairly robust to the choice of control genes.
We chose to use the 1000 genes found to have the highest p-values in the experiment of Vignali et al as controls. The experiment of Vignali et al looked at differences in expression between pregnancy associated malaria and childhood malaria. Although this is not the same association we are investigating it was considered close enough to perform adequately as a source of control genes. Further an analysis using SVA which does not require controls and rather estimates them empirically was found to produce similar results with only 5 out of 119 genes found using SVA missing from the RUV-4 approach. Further RUV-4 attempts to recover some variation that may be lost in the vanilla SVA approach when the factor of interest (severe disease) correlates with an unwanted factor. Consequently it leads to a higher number of differentially expressed genes being found. It was also thought that having an independently sourced set of control genes was preferable to empirically deriving such a set.
setwd(wd)
contol_genes_vignali <- read.table("./data/contol_genes_vignali.txt", quote = "\"")
ctrl_vignali <- geneID_mappings$current[geneID_mappings$old %in% contol_genes_vignali$V1]
length(ctrl_vignali)
## [1] 1009
empirical_controls <- ctrl_vignali[0:length(ctrl_vignali)]
empirical_controls <- rownames(v$E) %in% empirical_controls
categoriesRUV <- categories
categoriesRUV <- data.matrix(as.numeric(categoriesRUV == "S"))
ring <- data.matrix(mod[, c(1, 3)])
genes <- data.matrix(t(v$E))
ruv <- RUV4(genes, categoriesRUV, empirical_controls, 3, Z = ring)
modRUV = cbind(mod, ruv$W)
norm_counts_ring_ruv <- removeBatchEffect(v$E, covariates = modRUV[, 3:ncol(modRUV)], design = modRUV[, 1:2])
Note that although we used 1000 genes from the experiment of Vignali et al only 533 were found in our reduced expression matrix.
The PCA plot below indicates that we have dealt with most of the problems due to staging. Here we have included the Ring stage proportion from the mixture model as well as three factors of unwanted variation estimated using RUV-4.
setwd(wd)
plotPCA(norm_counts_ring_ruv, col = colors[categories], cex = 0.8, isLog = TRUE)
The RLE plot also indicates that we have succesfully dealt with most of the staging issues. Both SFC21 and IFM14 have reasonable box plots. Moreover, IFM060 has a nicer boxplot indicating that in using RUV-4, not only have we dealt with staging issues, we have also accounted for some other unknown confounding factors that would have impacted our results. The variation in each sample has also been reduced which is indicated in the reduced height of the boxplot whiskers. Finally, the results were found to be relatively robust to the removal of the outlier samples such as SFC21 and IFM14. Consequently, this approach seems to succesfully deal with both life-cycle staging issues and other unknown impacting factors.
setwd(wd)
plotVoomRLE(norm_counts_ring_ruv, colors[categories])
We now use the limma-voom pipeline, with the robust ebayes option which handles dispersion outliers. This was done to further ensure our results were less likely to be affected by outlier samples. Multiple testing correction was performed using the Benjamini-Hochberg approach.
setwd(wd)
stopifnot(colnames(dge) == rownames(modRUV))
v2 <- voom(dge, design = modRUV, plot = F)
fit <- lmFit(v2, modRUV)
fit <- eBayes(fit, robust = TRUE)
s <- summary(de2 <- decideTests(fit, adjust.method = "BH", p.value = 0.05))
s
## (Intercept) disease Ring
## -1 91 72 1393 1621 1101 478
## 0 548 4033 1450 1651 2070 3114
## 1 3505 39 1301 872 973 552
Overall 111 genes were found to be differentially expressed between severe and non-severe cases of malaria with a false dicovery rate threshold of 0.05.
A good check for validity of our model it to look at the distribution of the resulting p-values. If everything is okay we would expect a uniform distribution except near \(p=0\) where we would hope to see a spike. The barplot below indicates this is what we see which is helpful in affirming that we have done okay in removing unwanted variation without negatively impacting on the variation due to the variable of interest (diseas severity).
setwd(wd)
top_ring_ruv <- topTable(fit, coef = 2, p.value = 0.1, sort.by = "p", number = Inf, adjust.method = "BH", confint = TRUE)
hist <- data.frame(topTable(fit, coef = 2, number = Inf))
gg <- ggplot(hist, aes(x = P.Value)) + geom_histogram(binwidth = 0.01)
gg <- gg + theme_bw()
gg <- gg + theme(axis.text.x = element_text(size = 12), axis.text.y = element_text(size = 12, angle = 0), axis.title = element_text(size = 12, face = "bold"))
gg <- gg + labs(x = "P value", y = "Count")
gg
Below is a table of genes that were found to be differentially expressed, ordered by their respective p-values. The 95% confidence intervals are given with the estimated LFC as well as the BH adjusted p-values and the log-odds that the gene is differentially expressed. Here we report for interest sake all genes up to a adjusted p-value threshold of 0.1.
setwd(wd)
# Load additional gene information
GeneAnnotationPlasmoDB <- fread("./data/GeneAnnotationPlasmoDB.txt", data.table = FALSE, na.strings = "N/A")
# First lets import some additional gene information to make a nicer table
GeneAnnotationPlasmoDB <- GeneAnnotationPlasmoDB[, colnames(GeneAnnotationPlasmoDB) %in% c("[Gene ID]", "[Product Description]", "[Gene Name or Symbol]")]
top_ring_ruv <- merge(top_ring_ruv, GeneAnnotationPlasmoDB, by.x = 0, by.y = "[Gene ID]", all.x = TRUE)
top_ring_ruv <- top_ring_ruv[with(top_ring_ruv, order(adj.P.Val)), ]
# Now print the table
top_ring_ruv$P.Value <- format(top_ring_ruv$P.Value, scientific = TRUE, digits = 3)
top_ring_ruv$adj.P.Val <- format(top_ring_ruv$adj.P.Val, scientific = TRUE, digits = 3)
kable(top_ring_ruv[, c(2:4, 6:ncol(top_ring_ruv))], digits = 3)
| GeneID | Chr | Start | Strand | Length | logFC | CI.L | CI.R | AveExpr | t | P.Value | adj.P.Val | B | [Product Description] | [Gene Name or Symbol] | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 9 | PF3D7_0115700 | Pf3D7_01_v3 | 607390 | - | 7504 | -1.695 | -2.671 | -0.718 | 4.472 | -5.551 | 2.64e-06 | 5.48e-03 | 4.604 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 14 | PF3D7_0202000 | Pf3D7_02_v3 | 103385 | - | 2412 | -2.232 | -3.132 | -1.331 | 14.042 | -5.745 | 2.34e-06 | 5.48e-03 | 4.796 | knob-associated histidine-rich protein | KAHRP |
| 271 | PF3D7_1255200 | Pf3D7_12_v3 | 2241271 | - | 7692 | -1.490 | -2.030 | -0.951 | 4.566 | -5.412 | 4.07e-06 | 5.63e-03 | 4.217 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 23 | PF3D7_0223500 | Pf3D7_02_v3 | 916352 | - | 7297 | -1.139 | -1.932 | -0.345 | 5.205 | -4.963 | 1.63e-05 | 8.42e-03 | 2.967 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 31 | PF3D7_0316600 | Pf3D7_03_v3 | 669302 | - | 1572 | -1.407 | -1.944 | -0.870 | 10.248 | -5.170 | 9.43e-06 | 8.42e-03 | 3.437 | formate-nitrite transporter | FNT |
| 37 | PF3D7_0400100 | Pf3D7_04_v3 | 28706 | + | 8972 | -1.593 | -1.921 | -1.266 | 4.810 | -5.026 | 1.34e-05 | 8.42e-03 | 3.137 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 156 | PF3D7_0900100 | Pf3D7_09_v3 | 20080 | + | 7806 | -1.462 | -2.010 | -0.915 | 4.673 | -5.057 | 1.22e-05 | 8.42e-03 | 3.222 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 189 | PF3D7_1023600 | Pf3D7_10_v3 | 987358 | - | 2791 | -2.045 | -3.030 | -1.060 | -0.122 | -4.980 | 1.54e-05 | 8.42e-03 | 2.470 | conserved Plasmodium protein, unknown function | NA |
| 243 | PF3D7_1223900 | Pf3D7_12_v3 | 972710 | - | 684 | -2.228 | -4.701 | 0.246 | 2.658 | -4.936 | 1.86e-05 | 8.58e-03 | 2.759 | 50S ribosomal protein L24, putative | NA |
| 142 | PF3D7_0809100 | Pf3D7_08_v3 | 459312 | + | 7256 | -1.773 | -3.635 | 0.089 | 3.226 | -4.884 | 2.08e-05 | 8.60e-03 | 2.660 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 4 | PF3D7_0106000 | Pf3D7_01_v3 | 255775 | - | 2769 | 1.185 | 0.199 | 2.172 | 1.476 | 4.664 | 4.07e-05 | 1.23e-02 | 1.911 | conserved Plasmodium protein, unknown function | NA |
| 36 | PF3D7_0324900 | Pf3D7_03_v3 | 1030822 | - | 7433 | -1.274 | -2.295 | -0.254 | 3.988 | -4.507 | 6.54e-05 | 1.23e-02 | 1.679 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 40 | PF3D7_0404600 | Pf3D7_04_v3 | 247731 | + | 12417 | -1.457 | -1.770 | -1.145 | 7.604 | -4.502 | 7.43e-05 | 1.23e-02 | 1.518 | conserved Plasmodium membrane protein, unknown function | NA |
| 45 | PF3D7_0412700 | Pf3D7_04_v3 | 561667 | - | 7676 | -1.440 | -2.188 | -0.692 | 4.841 | -4.530 | 6.09e-05 | 1.23e-02 | 1.754 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 85 | PF3D7_0600600 | Pf3D7_06_v3 | 29618 | - | 1867 | -1.681 | -2.462 | -0.901 | 3.049 | -4.700 | 3.63e-05 | 1.23e-02 | 2.150 | erythrocyte membrane protein 1 (PfEMP1), exon 2 | VAR |
| 105 | PF3D7_0632800 | Pf3D7_06_v3 | 1374797 | - | 7831 | -1.240 | -1.577 | -0.904 | 4.681 | -4.544 | 5.85e-05 | 1.23e-02 | 1.791 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 107 | PF3D7_0703100 | Pf3D7_07_v3 | 121414 | + | 543 | 0.985 | 0.194 | 1.777 | 3.582 | 4.477 | 7.15e-05 | 1.23e-02 | 1.585 | conserved Plasmodium protein, unknown function | NA |
| 120 | PF3D7_0712600 | Pf3D7_07_v3 | 566726 | - | 7583 | -1.748 | -2.417 | -1.079 | 3.429 | -4.685 | 3.80e-05 | 1.23e-02 | 2.140 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 133 | PF3D7_0800100 | Pf3D7_08_v3 | 21361 | + | 7293 | -1.596 | -2.257 | -0.936 | 4.508 | -4.513 | 6.58e-05 | 1.23e-02 | 1.687 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 136 | PF3D7_0802000 | Pf3D7_08_v3 | 146089 | + | 4194 | -1.266 | -1.753 | -0.778 | 9.188 | -4.509 | 6.90e-05 | 1.23e-02 | 1.563 | glutamate dehydrogenase, putative | GDH3 |
| 175 | PF3D7_1000100 | Pf3D7_10_v3 | 28490 | + | 7675 | -1.339 | -1.639 | -1.040 | 4.505 | -4.569 | 5.41e-05 | 1.23e-02 | 1.861 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 204 | PF3D7_1105100 | Pf3D7_11_v3 | 226065 | + | 354 | -1.063 | -1.589 | -0.536 | 9.705 | -4.600 | 5.10e-05 | 1.23e-02 | 1.803 | histone H2B | H2B |
| 216 | PF3D7_1123100 | Pf3D7_11_v3 | 909366 | + | 6959 | -0.597 | -0.908 | -0.287 | 9.103 | -4.524 | 6.21e-05 | 1.23e-02 | 1.615 | calcium-dependent protein kinase 7 | CDPK7 |
| 231 | PF3D7_1200100 | Pf3D7_12_v3 | 16973 | + | 7525 | -1.592 | -2.227 | -0.957 | 4.052 | -4.609 | 4.80e-05 | 1.23e-02 | 1.962 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 296 | PF3D7_1344800 | Pf3D7_13_v3 | 1796274 | + | 1436 | -0.768 | -1.123 | -0.413 | 6.260 | -4.560 | 5.58e-05 | 1.23e-02 | 1.805 | aspartate carbamoyltransferase | ATCase |
| 248 | PF3D7_1228800 | Pf3D7_12_v3 | 1169557 | - | 9630 | -0.657 | -1.727 | 0.414 | 6.788 | -4.415 | 8.63e-05 | 1.38e-02 | 1.368 | WD repeat-containing protein, putative | NA |
| 84 | PF3D7_0532400 | Pf3D7_05_v3 | 1312471 | + | 1684 | -1.315 | -1.774 | -0.856 | 8.118 | -4.393 | 9.77e-05 | 1.40e-02 | 1.255 | lysine-rich membrane-associated PHISTb protein | LyMP |
| 102 | PF3D7_0626200 | Pf3D7_06_v3 | 1058666 | - | 1257 | 1.643 | 0.966 | 2.319 | 2.878 | 4.387 | 9.37e-05 | 1.40e-02 | 1.317 | conserved Plasmodium protein, unknown function | NA |
| 244 | PF3D7_1224000 | Pf3D7_12_v3 | 974372 | + | 1170 | -1.670 | -3.718 | 0.378 | 2.666 | -4.378 | 9.63e-05 | 1.40e-02 | 1.295 | GTP cyclohydrolase I | GCH1 |
| 322 | PF3D7_1414200 | Pf3D7_14_v3 | 564024 | - | 1224 | 0.818 | 0.286 | 1.349 | 5.924 | 4.353 | 1.04e-04 | 1.43e-02 | 1.236 | conserved Plasmodium protein, unknown function | NA |
| 198 | PF3D7_1100100 | Pf3D7_11_v3 | 24160 | + | 7439 | -1.288 | -1.828 | -0.748 | 4.713 | -4.310 | 1.18e-04 | 1.58e-02 | 1.149 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 6 | PF3D7_0109700 | Pf3D7_01_v3 | 379149 | - | 658 | -1.423 | -2.847 | 0.001 | 4.127 | -4.269 | 1.33e-04 | 1.73e-02 | 1.039 | rRNA biogenesis protein RRP36, putative | RRP36 |
| 71 | PF3D7_0519500 | Pf3D7_05_v3 | 801450 | - | 7678 | -0.942 | -1.573 | -0.311 | 7.017 | -4.157 | 1.86e-04 | 2.09e-02 | 0.644 | carbon catabolite repressor protein 4, putative | CCR4 |
| 153 | PF3D7_0830300 | Pf3D7_08_v3 | 1290240 | - | 1167 | 1.591 | 1.299 | 1.884 | 2.023 | 4.162 | 1.83e-04 | 2.09e-02 | 0.689 | sporozoite invasion-associated protein 2 | SIAP2 |
| 168 | PF3D7_0925300 | Pf3D7_09_v3 | 1019164 | - | 1740 | 2.109 | 1.367 | 2.850 | 0.173 | 4.158 | 1.86e-04 | 2.09e-02 | 0.526 | proline–tRNA ligase, putative | aPRS |
| 193 | PF3D7_1028000 | Pf3D7_10_v3 | 1160031 | + | 3391 | -0.991 | -1.656 | -0.326 | 6.363 | -4.158 | 1.86e-04 | 2.09e-02 | 0.671 | methyltransferase, putative | NA |
| 285 | PF3D7_1316600 | Pf3D7_13_v3 | 691014 | + | 3112 | -1.262 | -1.567 | -0.958 | 6.456 | -4.192 | 1.76e-04 | 2.09e-02 | 0.730 | choline-phosphate cytidylyltransferase | CCT |
| 117 | PF3D7_0711700 | Pf3D7_07_v3 | 511950 | - | 7476 | -1.151 | -1.908 | -0.394 | 4.402 | -4.081 | 2.34e-04 | 2.50e-02 | 0.535 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 287 | PF3D7_1318300 | Pf3D7_13_v3 | 753910 | + | 5523 | -1.051 | -1.390 | -0.712 | 5.766 | -4.078 | 2.36e-04 | 2.50e-02 | 0.479 | conserved Plasmodium protein, unknown function | NA |
| 166 | PF3D7_0917800 | Pf3D7_09_v3 | 734629 | + | 1314 | 1.808 | 1.549 | 2.068 | 1.383 | 4.051 | 2.55e-04 | 2.64e-02 | 0.373 | conserved Plasmodium protein, unknown function | NA |
| 58 | PF3D7_0500100 | Pf3D7_05_v3 | 20929 | + | 7528 | -1.287 | -1.826 | -0.748 | 3.399 | -4.023 | 2.77e-04 | 2.68e-02 | 0.383 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 224 | PF3D7_1135300 | Pf3D7_11_v3 | 1381015 | - | 1230 | 1.219 | 0.684 | 1.754 | 2.281 | 4.032 | 2.70e-04 | 2.68e-02 | 0.377 | conserved Plasmodium membrane protein, unknown function | NA |
| 238 | PF3D7_1213100 | Pf3D7_12_v3 | 576417 | - | 164 | -2.305 | -2.853 | -1.757 | 2.312 | -4.036 | 2.79e-04 | 2.68e-02 | 0.335 | U1 spliceosomal RNA | NA |
| 286 | PF3D7_1316900 | Pf3D7_13_v3 | 701047 | - | 2877 | 0.669 | 0.039 | 1.299 | 7.752 | 4.007 | 2.90e-04 | 2.73e-02 | 0.190 | conserved Plasmodium protein, unknown function | NA |
| 242 | PF3D7_1223400 | Pf3D7_12_v3 | 941125 | + | 5621 | -0.766 | -2.537 | 1.005 | 11.206 | -3.995 | 3.01e-04 | 2.77e-02 | 0.107 | phospholipid-transporting ATPase, putative | NA |
| 124 | PF3D7_0713600 | Pf3D7_07_v3 | 617933 | + | 2935 | 1.165 | 0.776 | 1.554 | 3.264 | 3.969 | 3.24e-04 | 2.92e-02 | 0.244 | mitochondrial ribosomal protein S5 precursor, putative | NA |
| 41 | PF3D7_0404900 | Pf3D7_04_v3 | 267244 | - | 1137 | 1.903 | 1.310 | 2.495 | 3.340 | 3.976 | 3.31e-04 | 2.92e-02 | 0.230 | 6-cysteine protein | P41 |
| 65 | PF3D7_0509000 | Pf3D7_05_v3 | 376855 | - | 1598 | -0.641 | -1.129 | -0.152 | 5.782 | -3.938 | 3.55e-04 | 2.94e-02 | 0.097 | SNAP protein (soluble N-ethylmaleimide-sensitive factor attachment protein), putative | NA |
| 143 | PF3D7_0810800 | Pf3D7_08_v3 | 548200 | + | 2417 | -1.107 | -1.926 | -0.288 | 7.387 | -3.954 | 3.49e-04 | 2.94e-02 | 0.068 | hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase | PPPK-DHPS |
| 275 | PF3D7_1303000 | Pf3D7_13_v3 | 158144 | + | 635 | -1.133 | -2.435 | 0.170 | 3.355 | -3.939 | 3.54e-04 | 2.94e-02 | 0.170 | conserved Plasmodium protein, unknown function | NA |
| 139 | PF3D7_0805600 | Pf3D7_08_v3 | 312034 | + | 927 | 0.774 | 0.335 | 1.213 | 7.188 | 3.895 | 4.02e-04 | 3.22e-02 | -0.092 | PAP2-like protein, putative | NA |
| 315 | PF3D7_1400100 | Pf3D7_14_v3 | 1393 | + | 3951 | -1.321 | -1.729 | -0.913 | 4.966 | -3.901 | 4.04e-04 | 3.22e-02 | 0.024 | erythrocyte membrane protein 1 (PfEMP1), pseudogene | NA |
| 251 | PF3D7_1230500 | Pf3D7_12_v3 | 1253973 | - | 1509 | 0.909 | -0.278 | 2.097 | 4.436 | 3.879 | 4.22e-04 | 3.30e-02 | 0.000 | WD repeat-containing protein, putative | NA |
| 24 | PF3D7_0300100 | Pf3D7_03_v3 | 36965 | + | 7518 | -1.134 | -1.505 | -0.762 | 4.351 | -3.865 | 4.39e-04 | 3.32e-02 | -0.033 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 265 | PF3D7_1246600 | Pf3D7_12_v3 | 1936522 | + | 1173 | -0.852 | -1.815 | 0.111 | 5.347 | -3.864 | 4.40e-04 | 3.32e-02 | -0.075 | pre-mRNA-splicing factor CWC26, putative | BUD13 |
| 7 | PF3D7_0113000 | Pf3D7_01_v3 | 487892 | - | 2236 | -1.480 | -3.080 | 0.121 | 11.345 | -3.858 | 5.27e-04 | 3.64e-02 | -0.381 | glutamic acid-rich protein | GARP |
| 237 | PF3D7_1212800 | Pf3D7_12_v3 | 565966 | + | 966 | 1.021 | 0.421 | 1.621 | 2.457 | 3.805 | 5.22e-04 | 3.64e-02 | -0.186 | iron-sulfur subunit of succinate dehydrogenase | NA |
| 260 | PF3D7_1240900 | Pf3D7_12_v3 | 1735543 | + | 7866 | -1.406 | -2.440 | -0.371 | 4.296 | -3.816 | 5.12e-04 | 3.64e-02 | -0.163 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 267 | PF3D7_1249000 | Pf3D7_12_v3 | 2005175 | - | 2019 | 1.002 | 0.352 | 1.652 | 1.154 | 3.821 | 4.98e-04 | 3.64e-02 | -0.193 | conserved Plasmodium membrane protein, unknown function | NA |
| 347 | PF3D7_1457000 | Pf3D7_14_v3 | 2336649 | - | 2505 | -0.648 | -1.396 | 0.101 | 8.961 | -3.813 | 5.11e-04 | 3.64e-02 | -0.368 | signal peptide peptidase | SPP |
| 83 | PF3D7_0532300 | Pf3D7_05_v3 | 1308278 | + | 1663 | -1.199 | -1.939 | -0.459 | 10.800 | -3.818 | 5.46e-04 | 3.65e-02 | -0.411 | Plasmodium exported protein (PHISTb), unknown function | NA |
| 316 | PF3D7_1401400 | Pf3D7_14_v3 | 53411 | - | 324 | -0.853 | -1.218 | -0.488 | 12.466 | -3.797 | 5.42e-04 | 3.65e-02 | -0.439 | early transcribed membrane protein 14.1 | ETRAMP14 |
| 111 | PF3D7_0704600 | Pf3D7_07_v3 | 216024 | - | 13049 | -0.663 | -1.466 | 0.140 | 10.228 | -3.766 | 5.84e-04 | 3.78e-02 | -0.518 | E3 ubiquitin-protein ligase | UT |
| 205 | PF3D7_1105300 | Pf3D7_11_v3 | 231847 | - | 2392 | 1.352 | 1.003 | 1.700 | 1.696 | 3.767 | 5.82e-04 | 3.78e-02 | -0.302 | conserved Plasmodium protein, unknown function | NA |
| 211 | PF3D7_1118400 | Pf3D7_11_v3 | 699869 | - | 921 | 1.065 | 0.445 | 1.685 | 3.280 | 3.756 | 6.02e-04 | 3.84e-02 | -0.298 | haloacid dehalogenase-like hydrolase, putative | NA |
| 262 | PF3D7_1244200 | Pf3D7_12_v3 | 1852844 | - | 2838 | 1.031 | 0.729 | 1.333 | 5.481 | 3.739 | 6.32e-04 | 3.97e-02 | -0.416 | RNA polymerase II transcription factor B subunit 2, putative | TFB2 |
| 54 | PF3D7_0419800 | Pf3D7_04_v3 | 874811 | - | 711 | 0.644 | 0.109 | 1.179 | 5.924 | 3.733 | 6.43e-04 | 3.98e-02 | -0.456 | 60S ribosomal protein L7ae/L30e, putative | NA |
| 13 | PF3D7_0201900 | Pf3D7_02_v3 | 91318 | - | 7521 | -1.527 | -2.211 | -0.843 | 10.614 | -3.763 | 6.87e-04 | 4.12e-02 | -0.606 | erythrocyte membrane protein 3 | EMP3 |
| 146 | PF3D7_0821500 | Pf3D7_08_v3 | 967901 | - | 840 | 0.820 | 0.569 | 1.070 | 4.918 | 3.706 | 6.94e-04 | 4.12e-02 | -0.467 | ribosomal RNA small subunit methyltransferase NEP1, putative | NEP1 |
| 147 | PF3D7_0822200 | Pf3D7_08_v3 | 982570 | + | 5127 | 1.108 | 0.550 | 1.666 | 2.942 | 3.700 | 7.07e-04 | 4.12e-02 | -0.439 | conserved Plasmodium membrane protein, unknown function | NA |
| 149 | PF3D7_0823800 | Pf3D7_08_v3 | 1043813 | + | 1968 | -0.753 | -1.486 | -0.020 | 5.245 | -3.700 | 7.05e-04 | 4.12e-02 | -0.514 | DnaJ protein, putative | NA |
| 51 | PF3D7_0417400 | Pf3D7_04_v3 | 756294 | + | 20310 | -0.792 | -1.152 | -0.432 | 8.067 | -3.685 | 7.37e-04 | 4.24e-02 | -0.697 | conserved Plasmodium protein, unknown function | NA |
| 121 | PF3D7_0712800 | Pf3D7_07_v3 | 581386 | - | 7538 | -1.348 | -2.079 | -0.616 | 4.007 | -3.677 | 7.57e-04 | 4.24e-02 | -0.507 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 154 | PF3D7_0831700 | Pf3D7_08_v3 | 1365467 | - | 2040 | -0.982 | -1.261 | -0.702 | 13.434 | -3.690 | 7.53e-04 | 4.24e-02 | -0.736 | heat shock protein 70 | HSP70-x |
| 1 | mal_rna_11:rRNA | M76611 | 1916 | - | 108 | -1.640 | -2.203 | -1.077 | 1.870 | -3.641 | 8.35e-04 | 4.27e-02 | -0.608 | NA | NA |
| 25 | PF3D7_0302800 | Pf3D7_03_v3 | 148046 | - | 1260 | 1.163 | 0.554 | 1.772 | 5.270 | 3.630 | 8.76e-04 | 4.27e-02 | -0.696 | conserved Plasmodium protein, unknown function | NA |
| 47 | PF3D7_0413900 | Pf3D7_04_v3 | 623168 | - | 3059 | -0.742 | -1.627 | 0.143 | 6.964 | -3.656 | 8.01e-04 | 4.27e-02 | -0.731 | ubiquitin carboxyl-terminal hydrolase 13, putative | USP13 |
| 57 | PF3D7_0423800 | Pf3D7_04_v3 | 1076347 | + | 1188 | 2.290 | 1.835 | 2.746 | 2.134 | 3.628 | 9.24e-04 | 4.27e-02 | -0.671 | cysteine-rich protective antigen | CyRPA |
| 68 | PF3D7_0512000 | Pf3D7_05_v3 | 527639 | + | 1028 | -1.030 | -1.691 | -0.369 | 5.218 | -3.609 | 9.15e-04 | 4.27e-02 | -0.737 | prefoldin subunit 6, putative | NA |
| 81 | PF3D7_0529000 | Pf3D7_05_v3 | 1186787 | - | 2160 | 0.470 | -0.311 | 1.252 | 7.651 | 3.631 | 8.60e-04 | 4.27e-02 | -0.825 | conserved Plasmodium protein, unknown function | NA |
| 103 | PF3D7_0629600 | Pf3D7_06_v3 | 1218307 | + | 945 | 0.546 | 0.103 | 0.988 | 4.979 | 3.605 | 9.25e-04 | 4.27e-02 | -0.730 | conserved Plasmodium protein, unknown function | NA |
| 116 | PF3D7_0711200 | Pf3D7_07_v3 | 495238 | + | 3003 | 1.222 | 0.659 | 1.785 | 2.256 | 3.636 | 8.47e-04 | 4.27e-02 | -0.605 | conserved Plasmodium protein, unknown function | NA |
| 132 | PF3D7_0733000 | Pf3D7_07_v3 | 1417588 | - | 8647 | -1.043 | -1.615 | -0.471 | 4.926 | -3.623 | 8.79e-04 | 4.27e-02 | -0.683 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 161 | PF3D7_0909600 | Pf3D7_09_v3 | 433238 | - | 2136 | 1.511 | 1.178 | 1.843 | 0.836 | 3.642 | 8.34e-04 | 4.27e-02 | -0.639 | conserved Plasmodium protein, unknown function | NA |
| 197 | PF3D7_1041300 | Pf3D7_10_v3 | 1642401 | - | 7548 | -1.101 | -1.727 | -0.474 | 4.981 | -3.628 | 8.68e-04 | 4.27e-02 | -0.670 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 213 | PF3D7_1121100 | Pf3D7_11_v3 | 794254 | - | 5308 | -0.793 | -1.429 | -0.157 | 8.461 | -3.604 | 9.27e-04 | 4.27e-02 | -0.908 | conserved Plasmodium protein, unknown function | NA |
| 298 | PF3D7_1346200 | Pf3D7_13_v3 | 1845878 | - | 507 | 2.002 | 1.693 | 2.312 | 0.978 | 3.614 | 9.19e-04 | 4.27e-02 | -0.704 | nuclear import protein MOG1, putative | NA |
| 326 | PF3D7_1421150 | Pf3D7_14_v3 | 875173 | - | 149 | -1.649 | -2.239 | -1.059 | 1.022 | -3.645 | 8.26e-04 | 4.27e-02 | -0.630 | C/D small nucleolar RNA | NA |
| 337 | PF3D7_1444800 | Pf3D7_14_v3 | 1844041 | - | 1577 | -0.692 | -1.263 | -0.122 | 10.290 | -3.622 | 8.81e-04 | 4.27e-02 | -0.895 | fructose-bisphosphate aldolase | FBPA |
| 346 | PF3D7_1451800 | Pf3D7_14_v3 | 2123461 | + | 3139 | -0.690 | -1.189 | -0.190 | 4.615 | -3.616 | 8.96e-04 | 4.27e-02 | -0.698 | sortilin | NA |
| 207 | PF3D7_1108700 | Pf3D7_11_v3 | 373238 | - | 1623 | 0.745 | 0.222 | 1.267 | 6.854 | 3.584 | 9.81e-04 | 4.47e-02 | -0.899 | heat shock protein DnaJ homologue Pfj2 | NA |
| 95 | PF3D7_0617200 | Pf3D7_06_v3 | 717050 | + | 1868 | -1.064 | -2.315 | 0.188 | 7.853 | -3.587 | 1.03e-03 | 4.57e-02 | -0.986 | conserved Plasmodium protein, unknown function | NA |
| 299 | PF3D7_1346400 | Pf3D7_13_v3 | 1852898 | + | 17967 | -0.706 | -0.963 | -0.449 | 7.849 | -3.569 | 1.02e-03 | 4.57e-02 | -0.999 | conserved Plasmodium protein, unknown function | NA |
| 259 | PF3D7_1240600 | Pf3D7_12_v3 | 1719574 | + | 7883 | -1.224 | -1.818 | -0.629 | 3.851 | -3.554 | 1.07e-03 | 4.66e-02 | -0.812 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 303 | PF3D7_1354300 | Pf3D7_13_v3 | 2164239 | - | 3178 | -0.517 | -1.135 | 0.102 | 9.432 | -3.556 | 1.06e-03 | 4.66e-02 | -1.072 | large subunit rRNA methyltransferase, putative | NA |
| 220 | PF3D7_1126300 | Pf3D7_11_v3 | 1026976 | + | 2569 | 1.067 | 0.818 | 1.316 | 4.596 | 3.543 | 1.10e-03 | 4.76e-02 | -0.874 | DnaJ protein, putative | NA |
| 62 | PF3D7_0503100 | Pf3D7_05_v3 | 127064 | - | 1614 | -1.336 | -1.742 | -0.929 | 2.177 | -3.504 | 1.23e-03 | 4.80e-02 | -0.920 | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative | IspE |
| 99 | PF3D7_0622700 | Pf3D7_06_v3 | 916000 | - | 1300 | 1.532 | 0.053 | 3.011 | 1.425 | 3.534 | 1.13e-03 | 4.80e-02 | -0.860 | conserved Plasmodium membrane protein, unknown function | NA |
| 128 | PF3D7_0719500 | Pf3D7_07_v3 | 854652 | - | 2003 | 0.995 | 0.204 | 1.786 | 1.461 | 3.509 | 1.21e-03 | 4.80e-02 | -0.923 | LEM3/CDC50 family protein, putative | NA |
| 170 | PF3D7_0928500 | Pf3D7_09_v3 | 1146239 | - | 959 | -1.164 | -2.209 | -0.119 | 2.608 | -3.509 | 1.21e-03 | 4.80e-02 | -0.908 | conserved Plasmodium protein, unknown function | NA |
| 177 | PF3D7_1003900 | Pf3D7_10_v3 | 177921 | + | 950 | 1.677 | 0.884 | 2.470 | 0.332 | 3.524 | 1.16e-03 | 4.80e-02 | -0.928 | conserved Plasmodium protein, unknown function | NA |
| 180 | PF3D7_1012000 | Pf3D7_10_v3 | 463493 | + | 3514 | -0.679 | -1.272 | -0.085 | 6.052 | -3.496 | 1.26e-03 | 4.80e-02 | -1.086 | E3 ubiquitin-protein ligase, putative | NA |
| 202 | PF3D7_1102800 | Pf3D7_11_v3 | 131703 | - | 285 | -0.910 | -1.825 | 0.006 | 13.470 | -3.540 | 1.15e-03 | 4.80e-02 | -1.132 | early transcribed membrane protein 11.2 | ETRAMP11.2 |
| 288 | PF3D7_1321600 | Pf3D7_13_v3 | 897716 | + | 3329 | 1.398 | 0.495 | 2.301 | 0.132 | 3.515 | 1.19e-03 | 4.80e-02 | -0.960 | phosphodiesterase gamma, putative | PDEgamma |
| 310 | PF3D7_1365600 | Pf3D7_13_v3 | 2621261 | + | 2740 | 0.733 | -0.151 | 1.617 | 4.139 | 3.495 | 1.26e-03 | 4.80e-02 | -0.965 | DNA topoisomerase VI, b subunit, putative | NA |
| 331 | PF3D7_1428100 | Pf3D7_14_v3 | 1098038 | - | 1914 | 0.966 | 0.460 | 1.473 | 3.882 | 3.497 | 1.26e-03 | 4.80e-02 | -0.957 | WW domain-binding protein 11, putative | NA |
| 341 | PF3D7_1446900 | Pf3D7_14_v3 | 1924425 | - | 2226 | 0.763 | 0.448 | 1.079 | 6.864 | 3.500 | 1.24e-03 | 4.80e-02 | -1.121 | glutaminyl-peptide cyclotransferase, putative | NA |
| 349 | PF3D7_1457900 | Pf3D7_14_v3 | 2375579 | + | 10368 | -0.756 | -1.417 | -0.094 | 5.650 | -3.528 | 1.15e-03 | 4.80e-02 | -0.973 | conserved Plasmodium protein, unknown function | NA |
| 356 | PF3D7_1470200 | Pf3D7_14_v3 | 2877586 | - | 1163 | -0.675 | -1.356 | 0.006 | 5.398 | -3.515 | 1.19e-03 | 4.80e-02 | -0.979 | conserved Plasmodium protein, unknown function | NA |
| 138 | PF3D7_0804900 | Pf3D7_08_v3 | 279711 | - | 1476 | 0.919 | -0.323 | 2.160 | 5.949 | 3.480 | 1.32e-03 | 4.96e-02 | -1.111 | GTPase-activating protein, putative | NA |
| 338 | PF3D7_1445600 | Pf3D7_14_v3 | 1871778 | + | 2604 | 0.679 | 0.247 | 1.112 | 8.272 | 3.476 | 1.33e-03 | 4.97e-02 | -1.254 | RNA-binding protein, putative | NA |
| 127 | PF3D7_0717600 | Pf3D7_07_v3 | 758720 | - | 4158 | -1.473 | -1.889 | -1.056 | 3.059 | -3.474 | 1.36e-03 | 5.02e-02 | -1.007 | conserved Plasmodium protein, unknown function | NA |
| 73 | PF3D7_0522300 | Pf3D7_05_v3 | 902613 | - | 2232 | -0.572 | -1.174 | 0.030 | 6.700 | -3.459 | 1.39e-03 | 5.09e-02 | -1.221 | S-adenosylmethionine-dependent methyltransferase, putative | NA |
| 343 | PF3D7_1449900 | Pf3D7_14_v3 | 2044007 | - | 1023 | 1.308 | 0.758 | 1.858 | 2.638 | 3.457 | 1.40e-03 | 5.09e-02 | -1.030 | conserved Plasmodium protein, unknown function | NA |
| 148 | PF3D7_0823200 | Pf3D7_08_v3 | 1022629 | - | 1218 | -0.619 | -0.974 | -0.264 | 9.617 | -3.453 | 1.42e-03 | 5.12e-02 | -1.345 | RNA-binding protein, putative | NA |
| 335 | PF3D7_1437800 | Pf3D7_14_v3 | 1530276 | - | 555 | 1.770 | 1.086 | 2.453 | 2.830 | 3.457 | 1.44e-03 | 5.16e-02 | -1.053 | trafficking protein particle complex subunit 5, putative | TRAPPC5 |
| 28 | PF3D7_0305000 | Pf3D7_03_v3 | 234058 | - | 1277 | 0.947 | 0.074 | 1.820 | 3.438 | 3.441 | 1.47e-03 | 5.16e-02 | -1.085 | elongation factor Ts | EF-Ts |
| 209 | PF3D7_1111300 | Pf3D7_11_v3 | 442959 | - | 870 | 0.841 | 0.548 | 1.135 | 2.945 | 3.438 | 1.48e-03 | 5.16e-02 | -1.078 | SNARE protein, putative | GS27 |
| 305 | PF3D7_1355700 | Pf3D7_13_v3 | 2206592 | - | 3867 | 1.237 | 0.365 | 2.109 | 7.278 | 3.465 | 1.48e-03 | 5.16e-02 | -1.290 | NLI interacting factor-like phosphatase, putative | NIF3 |
| 19 | PF3D7_0216000 | Pf3D7_02_v3 | 658636 | + | 5994 | -2.074 | -2.621 | -1.528 | 0.535 | -3.431 | 1.53e-03 | 5.29e-02 | -1.144 | DEAD/DEAH box helicase, putative | NA |
| 53 | PF3D7_0419500 | Pf3D7_04_v3 | 866501 | - | 1611 | 1.223 | 0.163 | 2.283 | 3.890 | 3.421 | 1.55e-03 | 5.30e-02 | -1.142 | conserved Plasmodium membrane protein, unknown function | NA |
| 114 | PF3D7_0708500 | Pf3D7_07_v3 | 385583 | - | 2739 | -0.737 | -1.370 | -0.105 | 6.652 | -3.415 | 1.58e-03 | 5.35e-02 | -1.331 | heat shock protein 86 family protein | NA |
| 69 | PF3D7_0513600 | Pf3D7_05_v3 | 574941 | - | 3565 | -1.045 | -1.363 | -0.726 | 5.614 | -3.413 | 1.61e-03 | 5.39e-02 | -1.279 | deoxyribodipyrimidine photo-lyase, putative | NA |
| 210 | PF3D7_1115200 | Pf3D7_11_v3 | 576773 | + | 3504 | -0.659 | -1.554 | 0.236 | 8.247 | -3.404 | 1.63e-03 | 5.39e-02 | -1.438 | histone-lysine N-methyltransferase SET7 | SET7 |
| 229 | PF3D7_1145500 | Pf3D7_11_v3 | 1807359 | + | 2772 | 1.102 | 0.252 | 1.951 | 1.564 | 3.404 | 1.63e-03 | 5.39e-02 | -1.164 | ABC transporter B family member 3, putative | ABCB3 |
| 59 | PF3D7_0501300 | Pf3D7_05_v3 | 68930 | + | 1184 | -0.925 | -1.601 | -0.250 | 12.486 | -3.399 | 1.71e-03 | 5.59e-02 | -1.510 | skeleton-binding protein 1 | SBP1 |
| 246 | PF3D7_1225600 | Pf3D7_12_v3 | 1035261 | - | 2895 | -0.478 | -2.453 | 1.498 | 8.007 | -3.386 | 1.71e-03 | 5.59e-02 | -1.479 | conserved Plasmodium protein, unknown function | NA |
| 324 | PF3D7_1417600 | Pf3D7_14_v3 | 730694 | - | 13989 | -0.568 | -1.358 | 0.222 | 8.915 | -3.382 | 1.73e-03 | 5.59e-02 | -1.516 | conserved Plasmodium protein, unknown function | NA |
| 297 | PF3D7_1345200 | Pf3D7_13_v3 | 1812220 | - | 1710 | 1.084 | 0.716 | 1.452 | 3.402 | 3.379 | 1.74e-03 | 5.59e-02 | -1.225 | rhomboid protease ROM6, putative | ROM6 |
| 29 | PF3D7_0310800 | Pf3D7_03_v3 | 464662 | + | 330 | 0.487 | -0.214 | 1.187 | 6.132 | 3.360 | 1.84e-03 | 5.68e-02 | -1.434 | conserved Plasmodium protein, unknown function | NA |
| 122 | PF3D7_0712900 | Pf3D7_07_v3 | 590326 | - | 7408 | -1.100 | -1.332 | -0.869 | 4.206 | -3.367 | 1.80e-03 | 5.68e-02 | -1.291 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 190 | PF3D7_1025000 | Pf3D7_10_v3 | 1045608 | - | 4153 | -0.570 | -0.985 | -0.156 | 8.252 | -3.366 | 1.80e-03 | 5.68e-02 | -1.528 | formin 2, putative | NA |
| 212 | PF3D7_1119200 | Pf3D7_11_v3 | 722717 | - | 573 | -1.038 | -1.443 | -0.632 | 3.783 | -3.361 | 1.83e-03 | 5.68e-02 | -1.277 | conserved protein, unknown function | NA |
| 218 | PF3D7_1124800 | Pf3D7_11_v3 | 976880 | - | 1057 | -0.568 | -1.158 | 0.023 | 6.670 | -3.363 | 1.82e-03 | 5.68e-02 | -1.464 | nuclear preribosomal assembly protein, putative | NA |
| 234 | PF3D7_1206300 | Pf3D7_12_v3 | 281020 | - | 8283 | -1.407 | -1.752 | -1.062 | 1.456 | -3.354 | 1.87e-03 | 5.73e-02 | -1.281 | conserved Plasmodium protein, unknown function | NA |
| 50 | PF3D7_0416100 | Pf3D7_04_v3 | 706529 | + | 2481 | -0.909 | -1.422 | -0.396 | 4.248 | -3.345 | 1.91e-03 | 5.78e-02 | -1.356 | glutamyl-tRNA(Gln) amidotransferase subunit A | GATA |
| 106 | PF3D7_0700100 | Pf3D7_07_v3 | 20307 | + | 7777 | -1.044 | -1.871 | -0.217 | 5.158 | -3.344 | 1.93e-03 | 5.78e-02 | -1.407 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 203 | PF3D7_1103400 | Pf3D7_11_v3 | 146427 | + | 4389 | 1.198 | -0.028 | 2.425 | 3.263 | 3.343 | 1.93e-03 | 5.78e-02 | -1.308 | FeS cluster assembly protein SufD, putative | SufD |
| 42 | PF3D7_0405400 | Pf3D7_04_v3 | 291251 | + | 9726 | -0.562 | -1.533 | 0.410 | 10.748 | -3.333 | 1.97e-03 | 5.87e-02 | -1.659 | pre-mRNA-processing-splicing factor 8, putative | PRPF8 |
| 56 | PF3D7_0421300 | Pf3D7_04_v3 | 969031 | - | 7561 | -1.056 | -1.582 | -0.531 | 4.877 | -3.320 | 2.05e-03 | 5.87e-02 | -1.443 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 247 | PF3D7_1226600 | Pf3D7_12_v3 | 1077868 | - | 909 | 1.498 | 0.096 | 2.900 | -0.283 | 3.319 | 2.05e-03 | 5.87e-02 | -1.410 | proliferating cell nuclear antigen 2 | PCNA2 |
| 255 | PF3D7_1234500 | Pf3D7_12_v3 | 1439896 | - | 1155 | 0.626 | 0.114 | 1.138 | 4.918 | 3.325 | 2.02e-03 | 5.87e-02 | -1.431 | conserved Plasmodium protein, unknown function | NA |
| 308 | PF3D7_1364000 | Pf3D7_13_v3 | 2564625 | + | 2484 | 0.987 | 0.420 | 1.554 | 3.797 | 3.328 | 2.01e-03 | 5.87e-02 | -1.366 | conserved Plasmodium protein, unknown function | NA |
| 313 | PF3D7_1372100 | Pf3D7_13_v3 | 2837053 | + | 2006 | 3.129 | 2.299 | 3.958 | 1.578 | 3.365 | 2.06e-03 | 5.87e-02 | -1.337 | Plasmodium exported protein (PHISTb), unknown function | GEXP04 |
| 339 | PF3D7_1445800 | Pf3D7_14_v3 | 1878658 | - | 3920 | 1.067 | 0.776 | 1.358 | 1.539 | 3.321 | 2.05e-03 | 5.87e-02 | -1.356 | conserved Plasmodium membrane protein, unknown function | NA |
| 280 | PF3D7_1307700 | Pf3D7_13_v3 | 344525 | + | 3708 | 0.582 | -0.368 | 1.531 | 6.383 | 3.313 | 2.09e-03 | 5.94e-02 | -1.576 | conserved Plasmodium protein, unknown function | NA |
| 109 | PF3D7_0703400 | Pf3D7_07_v3 | 129370 | - | 2463 | 1.161 | 0.838 | 1.484 | 3.395 | 3.307 | 2.12e-03 | 5.99e-02 | -1.403 | conserved Plasmodium protein, unknown function | NA |
| 183 | PF3D7_1016100 | Pf3D7_10_v3 | 643558 | - | 774 | 1.160 | 0.663 | 1.658 | 0.683 | 3.303 | 2.15e-03 | 6.01e-02 | -1.411 | conserved Plasmodium protein, unknown function | NA |
| 358 | PF3D7_1477700 | Pf3D7_14_v3 | 3202931 | + | 1087 | 2.091 | 1.317 | 2.865 | 1.770 | 3.316 | 2.17e-03 | 6.04e-02 | -1.395 | Plasmodium exported protein (PHISTa), unknown function | Pfg14-748 |
| 64 | PF3D7_0508700 | Pf3D7_05_v3 | 358261 | + | 4473 | -0.499 | -1.326 | 0.327 | 7.639 | -3.287 | 2.24e-03 | 6.05e-02 | -1.715 | pre-mRNA-processing ATP-dependent RNA helicase PRP5, putative | PRP5 |
| 144 | PF3D7_0814100 | Pf3D7_08_v3 | 682518 | - | 1055 | 0.938 | -0.783 | 2.659 | 4.348 | 3.287 | 2.24e-03 | 6.05e-02 | -1.489 | conserved Plasmodium protein, unknown function | NA |
| 178 | PF3D7_1009300 | Pf3D7_10_v3 | 377906 | - | 1803 | 1.211 | 0.885 | 1.536 | 3.019 | 3.287 | 2.24e-03 | 6.05e-02 | -1.439 | conserved Plasmodium protein, unknown function | NA |
| 295 | PF3D7_1344200 | Pf3D7_13_v3 | 1769129 | + | 2799 | -0.564 | -1.236 | 0.108 | 9.434 | -3.286 | 2.25e-03 | 6.05e-02 | -1.770 | heat shock protein 110, putative | HSP110 |
| 330 | PF3D7_1427200 | Pf3D7_14_v3 | 1061805 | + | 975 | -1.619 | -2.155 | -1.082 | 1.505 | -3.289 | 2.25e-03 | 6.05e-02 | -1.430 | selenoprotein | Sel4 |
| 44 | PF3D7_0412400 | Pf3D7_04_v3 | 545987 | - | 7824 | -0.919 | -1.577 | -0.261 | 3.465 | -3.283 | 2.27e-03 | 6.06e-02 | -1.456 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 32 | PF3D7_0317100 | Pf3D7_03_v3 | 686282 | + | 3201 | 0.874 | 0.596 | 1.152 | 2.504 | 3.274 | 2.33e-03 | 6.06e-02 | -1.463 | 6-cysteine protein | B9 |
| 82 | PF3D7_0531000 | Pf3D7_05_v3 | 1267410 | + | 2130 | 0.713 | -0.601 | 2.027 | 4.964 | 3.276 | 2.31e-03 | 6.06e-02 | -1.555 | conserved Plasmodium protein, unknown function | NA |
| 134 | PF3D7_0800300 | Pf3D7_08_v3 | 40948 | + | 9992 | -1.073 | -1.392 | -0.753 | 5.027 | -3.282 | 2.29e-03 | 6.06e-02 | -1.549 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 289 | PF3D7_1321700 | Pf3D7_13_v3 | 902383 | + | 2784 | -0.538 | -0.896 | -0.181 | 9.122 | -3.276 | 2.31e-03 | 6.06e-02 | -1.792 | splicing factor 1 | SF1 |
| 273 | PF3D7_1302700 | Pf3D7_13_v3 | 145174 | + | 5025 | -0.474 | -1.190 | 0.241 | 8.882 | -3.270 | 2.35e-03 | 6.09e-02 | -1.802 | ATP-dependent RNA helicase DHR1, putative | NA |
| 169 | PF3D7_0926500 | Pf3D7_09_v3 | 1075915 | - | 5769 | 1.173 | 0.733 | 1.614 | 0.469 | 3.256 | 2.44e-03 | 6.26e-02 | -1.520 | conserved Plasmodium protein, unknown function | NA |
| 221 | PF3D7_1128100 | Pf3D7_11_v3 | 1094909 | - | 1023 | -0.703 | -1.004 | -0.402 | 5.252 | -3.253 | 2.46e-03 | 6.26e-02 | -1.631 | prefoldin subunit 5, putative | NA |
| 233 | PF3D7_1205700 | Pf3D7_12_v3 | 253155 | + | 969 | 1.229 | 0.775 | 1.684 | 0.855 | 3.254 | 2.45e-03 | 6.26e-02 | -1.517 | targeted glyoxalase II | tGloII |
| 17 | PF3D7_0209700 | Pf3D7_02_v3 | 400153 | - | 1707 | 0.555 | -0.119 | 1.228 | 8.789 | 3.232 | 2.61e-03 | 6.32e-02 | -1.893 | RING zinc finger protein, putative | NA |
| 22 | PF3D7_0220500 | Pf3D7_02_v3 | 823825 | - | 1040 | -0.875 | -2.077 | 0.327 | 6.458 | -3.238 | 2.57e-03 | 6.32e-02 | -1.752 | Plasmodium exported protein (hyp2), unknown function | NA |
| 87 | PF3D7_0606800 | Pf3D7_06_v3 | 288377 | - | 900 | 1.551 | 1.311 | 1.791 | 3.382 | 3.241 | 2.60e-03 | 6.32e-02 | -1.571 | probable protein, unknown function | NA |
| 130 | PF3D7_0723900 | Pf3D7_07_v3 | 1000701 | - | 4046 | -0.612 | -0.899 | -0.325 | 7.826 | -3.238 | 2.57e-03 | 6.32e-02 | -1.844 | RNA-binding protein, putative | NA |
| 187 | PF3D7_1021900 | Pf3D7_10_v3 | 905473 | - | 6873 | -0.993 | -1.349 | -0.638 | 6.736 | -3.246 | 2.57e-03 | 6.32e-02 | -1.778 | PHAX domain-containing protein, putative | NA |
| 199 | PF3D7_1100300 | Pf3D7_11_v3 | 45056 | + | 1178 | 1.993 | 1.575 | 2.412 | -0.537 | 3.236 | 2.60e-03 | 6.32e-02 | -1.602 | rifin | RIF |
| 241 | PF3D7_1217000 | Pf3D7_12_v3 | 674349 | - | 429 | 1.119 | 0.313 | 1.924 | 1.672 | 3.236 | 2.58e-03 | 6.32e-02 | -1.547 | conserved Plasmodium protein, unknown function | NA |
| 317 | PF3D7_1401600 | Pf3D7_14_v3 | 61364 | - | 1625 | -0.760 | -1.042 | -0.478 | 8.852 | -3.236 | 2.61e-03 | 6.32e-02 | -1.894 | Plasmodium exported protein (PHISTb), unknown function | NA |
| 70 | PF3D7_0518300 | Pf3D7_05_v3 | 759831 | - | 1168 | -0.484 | -0.912 | -0.056 | 6.571 | -3.226 | 2.65e-03 | 6.33e-02 | -1.804 | proteasome subunit beta type-1, putative | NA |
| 72 | PF3D7_0521000 | Pf3D7_05_v3 | 859373 | - | 1691 | -0.687 | -1.390 | 0.017 | 5.971 | -3.225 | 2.66e-03 | 6.33e-02 | -1.757 | conserved Plasmodium protein, unknown function | NA |
| 98 | PF3D7_0621500 | Pf3D7_06_v3 | 881963 | + | 1032 | 1.065 | 0.072 | 2.058 | 1.161 | 3.225 | 2.65e-03 | 6.33e-02 | -1.575 | ribonuclease P/MRP protein subunit RPP1, putative | RPP1 |
| 174 | PF3D7_0936800 | Pf3D7_09_v3 | 1458392 | + | 1471 | -0.876 | -1.190 | -0.562 | 10.878 | -3.220 | 2.77e-03 | 6.48e-02 | -1.951 | Plasmodium exported protein (PHISTc), unknown function | NA |
| 181 | PF3D7_1013000 | Pf3D7_10_v3 | 500210 | + | 2012 | 1.140 | 0.529 | 1.751 | 2.844 | 3.208 | 2.78e-03 | 6.48e-02 | -1.622 | zinc finger protein, putative | NA |
| 184 | PF3D7_1016200 | Pf3D7_10_v3 | 646054 | + | 1683 | 1.055 | 0.321 | 1.789 | 4.570 | 3.206 | 2.80e-03 | 6.48e-02 | -1.706 | Rab3 GTPase-activating protein non-catalytic subunit, putative | NA |
| 227 | PF3D7_1140800 | Pf3D7_11_v3 | 1633920 | + | 2412 | 0.505 | -0.045 | 1.055 | 6.676 | 3.212 | 2.75e-03 | 6.48e-02 | -1.843 | conserved Plasmodium protein, unknown function | NA |
| 230 | PF3D7_1149500 | Pf3D7_11_v3 | 1991359 | - | 2660 | -0.653 | -1.498 | 0.192 | 8.007 | -3.204 | 2.81e-03 | 6.48e-02 | -1.921 | ring-infected erythrocyte surface antigen 2, pseudogene | RESA2 |
| 319 | PF3D7_1410500 | Pf3D7_14_v3 | 423751 | - | 500 | 1.042 | 0.705 | 1.378 | 1.400 | 3.205 | 2.80e-03 | 6.48e-02 | -1.619 | conserved Plasmodium protein, unknown function | NA |
| 104 | PF3D7_0631600 | Pf3D7_06_v3 | 1323294 | + | 1142 | -1.234 | -1.641 | -0.828 | 2.559 | -3.201 | 2.83e-03 | 6.49e-02 | -1.630 | exported protein family 4 | EPF4 |
| 323 | PF3D7_1414500 | Pf3D7_14_v3 | 578369 | - | 9161 | -0.636 | -0.920 | -0.351 | 7.984 | -3.197 | 2.86e-03 | 6.52e-02 | -1.959 | atypical protein kinase, ABC-1 family, putative | ABCk2 |
| 12 | PF3D7_0201800 | Pf3D7_02_v3 | 86832 | - | 1960 | -0.527 | -0.803 | -0.252 | 9.437 | -3.178 | 3.02e-03 | 6.61e-02 | -2.040 | knob associated heat shock protein 40 | KAHsp40 |
| 33 | PF3D7_0317500 | Pf3D7_03_v3 | 716523 | - | 5309 | 0.587 | -0.080 | 1.253 | 7.115 | 3.180 | 3.00e-03 | 6.61e-02 | -1.955 | kinesin-5 | EG5 |
| 52 | PF3D7_0418300 | Pf3D7_04_v3 | 819362 | - | 2979 | 0.610 | 0.114 | 1.106 | 10.470 | 3.186 | 2.95e-03 | 6.61e-02 | -2.029 | conserved Plasmodium protein, unknown function | NA |
| 67 | PF3D7_0511000 | Pf3D7_05_v3 | 467585 | - | 516 | -0.538 | -0.738 | -0.337 | 8.120 | -3.185 | 2.96e-03 | 6.61e-02 | -1.981 | translationally-controlled tumor protein homolog | TCTP |
| 263 | PF3D7_1244300 | Pf3D7_12_v3 | 1857849 | + | 242 | -1.945 | -2.961 | -0.930 | 2.568 | -3.199 | 2.97e-03 | 6.61e-02 | -1.661 | ACEA small nucleolar RNA U3 | NA |
| 277 | PF3D7_1304300 | Pf3D7_13_v3 | 231083 | + | 642 | 1.477 | 0.660 | 2.294 | 0.552 | 3.180 | 3.00e-03 | 6.61e-02 | -1.685 | conserved Plasmodium protein, unknown function | NA |
| 278 | PF3D7_1305400 | Pf3D7_13_v3 | 268785 | - | 1953 | 0.561 | 0.218 | 0.904 | 5.309 | 3.182 | 2.98e-03 | 6.61e-02 | -1.816 | AAR2 protein, putative | NA |
| 34 | PF3D7_0319600 | Pf3D7_03_v3 | 817913 | + | 783 | -0.442 | -0.957 | 0.073 | 8.336 | -3.170 | 3.08e-03 | 6.72e-02 | -2.039 | elongation factor 1 (EF-1), putative | NA |
| 195 | PF3D7_1035800 | Pf3D7_10_v3 | 1420533 | + | 2139 | -1.293 | -1.677 | -0.909 | 9.469 | -3.201 | 3.10e-03 | 6.72e-02 | -2.001 | probable protein, unknown function | M712 |
| 283 | PF3D7_1309400 | Pf3D7_13_v3 | 431892 | + | 3984 | -0.750 | -1.414 | -0.086 | 5.757 | -3.166 | 3.12e-03 | 6.72e-02 | -1.880 | HORMA domain protein, putative | NA |
| 173 | PF3D7_0935900 | Pf3D7_09_v3 | 1420483 | - | 2325 | -0.762 | -1.083 | -0.440 | 13.744 | -3.169 | 3.13e-03 | 6.73e-02 | -2.065 | ring-exported protein 1 | REX1 |
| 152 | PF3D7_0829100 | Pf3D7_08_v3 | 1252349 | + | 1448 | -0.521 | -1.286 | 0.244 | 7.060 | -3.160 | 3.16e-03 | 6.75e-02 | -2.000 | conserved protein, unknown function | NA |
| 222 | PF3D7_1133000 | Pf3D7_11_v3 | 1275574 | + | 90 | 1.310 | 0.942 | 1.678 | 0.955 | 3.158 | 3.18e-03 | 6.77e-02 | -1.728 | conserved Plasmodium protein, unknown function | NA |
| 16 | PF3D7_0205400 | Pf3D7_02_v3 | 223478 | + | 1374 | 0.446 | 0.105 | 0.787 | 6.179 | 3.149 | 3.26e-03 | 6.80e-02 | -1.963 | PCI domain-containing protein, putative | NA |
| 55 | PF3D7_0420000 | Pf3D7_04_v3 | 894612 | - | 10113 | -0.524 | -1.375 | 0.327 | 9.311 | -3.146 | 3.29e-03 | 6.80e-02 | -2.119 | zinc finger protein, putative | NA |
| 182 | PF3D7_1015800 | Pf3D7_10_v3 | 633682 | + | 1605 | 1.197 | 0.525 | 1.870 | 0.318 | 3.151 | 3.24e-03 | 6.80e-02 | -1.750 | ribonucleoside-diphosphate reductase small chain, putative | NA |
| 258 | PF3D7_1240400 | Pf3D7_12_v3 | 1704512 | + | 7979 | -0.936 | -1.157 | -0.715 | 4.827 | -3.148 | 3.27e-03 | 6.80e-02 | -1.853 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 355 | PF3D7_1468100 | Pf3D7_14_v3 | 2786308 | - | 8016 | -0.558 | -0.954 | -0.161 | 10.206 | -3.146 | 3.28e-03 | 6.80e-02 | -2.127 | conserved Plasmodium protein, unknown function | NA |
| 357 | PF3D7_1472300 | Pf3D7_14_v3 | 2954108 | + | 3001 | 1.050 | 0.167 | 1.932 | 4.451 | 3.145 | 3.30e-03 | 6.80e-02 | -1.839 | conserved Plasmodium membrane protein, unknown function | NA |
| 66 | PF3D7_0509800 | Pf3D7_05_v3 | 410268 | + | 5041 | -0.385 | -0.757 | -0.013 | 8.254 | -3.141 | 3.33e-03 | 6.80e-02 | -2.107 | phosphatidylinositol 4-kinase | PI4K |
| 232 | PF3D7_1200200 | Pf3D7_12_v3 | 26321 | - | 1367 | -1.845 | -2.273 | -1.417 | -0.252 | -3.141 | 3.33e-03 | 6.80e-02 | -1.800 | rifin | RIF |
| 226 | PF3D7_1140200 | Pf3D7_11_v3 | 1601257 | - | 1822 | -1.160 | -1.579 | -0.742 | 3.820 | -3.140 | 3.35e-03 | 6.81e-02 | -1.823 | conserved Plasmodium protein, unknown function | NA |
| 348 | PF3D7_1457100 | Pf3D7_14_v3 | 2340784 | + | 2244 | -0.895 | -1.549 | -0.240 | 6.629 | -3.139 | 3.39e-03 | 6.85e-02 | -2.007 | conserved Plasmodium protein, unknown function | NA |
| 200 | PF3D7_1102600 | Pf3D7_11_v3 | 123818 | - | 919 | 1.461 | 0.883 | 2.039 | 2.317 | 3.132 | 3.43e-03 | 6.91e-02 | -1.790 | Plasmodium exported protein, unknown function | GEXP14 |
| 112 | PF3D7_0705600 | Pf3D7_07_v3 | 281035 | - | 3399 | 0.833 | 0.363 | 1.303 | 3.988 | 3.125 | 3.48e-03 | 6.96e-02 | -1.853 | RNA helicase, putative | NA |
| 352 | PF3D7_1460500 | Pf3D7_14_v3 | 2466091 | + | 4899 | 1.016 | 0.429 | 1.604 | 2.431 | 3.123 | 3.49e-03 | 6.96e-02 | -1.806 | conserved Plasmodium protein, unknown function | NA |
| 3 | PF3D7_0101000 | Pf3D7_01_v3 | 65817 | - | 1173 | -2.246 | -2.928 | -1.565 | -1.073 | -3.119 | 3.57e-03 | 7.06e-02 | -1.886 | rifin | RIF |
| 90 | PF3D7_0609700 | Pf3D7_06_v3 | 413652 | + | 6130 | -0.563 | -1.557 | 0.430 | 9.552 | -3.111 | 3.61e-03 | 7.06e-02 | -2.204 | conserved Plasmodium protein, unknown function | NA |
| 186 | PF3D7_1019300 | Pf3D7_10_v3 | 774929 | - | 5559 | 0.842 | 0.580 | 1.103 | 4.369 | 3.114 | 3.58e-03 | 7.06e-02 | -1.899 | zinc finger protein, putative | NA |
| 272 | PF3D7_1301400 | Pf3D7_13_v3 | 82718 | + | 1301 | -0.891 | -1.162 | -0.619 | 8.053 | -3.118 | 3.61e-03 | 7.06e-02 | -2.123 | Plasmodium exported protein (hyp12), unknown function | HYP12 |
| 165 | PF3D7_0915500 | Pf3D7_09_v3 | 657418 | + | 1995 | 1.320 | 0.789 | 1.851 | 0.044 | 3.109 | 3.63e-03 | 7.07e-02 | -1.849 | conserved Plasmodium protein, unknown function | NA |
| 123 | PF3D7_0713500 | Pf3D7_07_v3 | 614385 | + | 2865 | 0.925 | 0.534 | 1.316 | 4.314 | 3.100 | 3.72e-03 | 7.07e-02 | -1.935 | conserved Plasmodium protein, unknown function | NA |
| 141 | PF3D7_0808700 | Pf3D7_08_v3 | 440408 | + | 7655 | -0.981 | -1.345 | -0.618 | 4.547 | -3.102 | 3.69e-03 | 7.07e-02 | -1.948 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 145 | PF3D7_0817100 | Pf3D7_08_v3 | 774299 | + | 2493 | 1.043 | 0.215 | 1.870 | 0.070 | 3.101 | 3.70e-03 | 7.07e-02 | -1.866 | tRNA modification GTPase, putative | NA |
| 162 | PF3D7_0913100 | Pf3D7_09_v3 | 571031 | - | 2319 | 1.169 | 0.432 | 1.905 | -0.164 | 3.102 | 3.69e-03 | 7.07e-02 | -1.868 | conserved Plasmodium protein, unknown function | NA |
| 345 | PF3D7_1451100 | Pf3D7_14_v3 | 2090902 | + | 2499 | -0.648 | -1.295 | -0.001 | 12.559 | -3.105 | 3.67e-03 | 7.07e-02 | -2.224 | elongation factor 2 | eEF2 |
| 281 | PF3D7_1308300 | Pf3D7_13_v3 | 372260 | + | 387 | 0.444 | -0.083 | 0.971 | 7.958 | 3.092 | 3.80e-03 | 7.19e-02 | -2.215 | 40S ribosomal protein S27 | RPS27 |
| 27 | PF3D7_0304900 | Pf3D7_03_v3 | 231793 | - | 513 | 0.801 | 0.116 | 1.486 | 5.085 | 3.080 | 3.92e-03 | 7.22e-02 | -2.030 | conserved Plasmodium protein, unknown function | NA |
| 76 | PF3D7_0524800 | Pf3D7_05_v3 | 1021408 | - | 2900 | 0.882 | 0.028 | 1.736 | 3.247 | 3.087 | 3.84e-03 | 7.22e-02 | -1.912 | ubiquitin fusion degradation protein 1, putative | UFD1 |
| 225 | PF3D7_1137300 | Pf3D7_11_v3 | 1466197 | - | 2070 | 0.450 | -0.267 | 1.166 | 7.350 | 3.080 | 3.92e-03 | 7.22e-02 | -2.212 | CLPTM1 domain-containing protein, putative | NA |
| 252 | PF3D7_1231600 | Pf3D7_12_v3 | 1301098 | - | 3507 | -0.706 | -1.747 | 0.336 | 6.288 | -3.084 | 3.88e-03 | 7.22e-02 | -2.134 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP2, putative | PRP2 |
| 282 | PF3D7_1309100 | Pf3D7_13_v3 | 418820 | + | 1302 | -0.722 | -1.280 | -0.165 | 8.832 | -3.088 | 3.87e-03 | 7.22e-02 | -2.260 | 60S ribosomal protein L24, putative | NA |
| 291 | PF3D7_1324200 | Pf3D7_13_v3 | 1000100 | - | 1783 | -0.797 | -1.141 | -0.454 | 7.145 | -3.086 | 3.89e-03 | 7.22e-02 | -2.185 | micro-fibrillar-associated protein, putative | NA |
| 119 | PF3D7_0712300 | Pf3D7_07_v3 | 542906 | - | 7615 | -1.223 | -2.264 | -0.181 | 3.752 | -3.079 | 3.97e-03 | 7.25e-02 | -1.967 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 307 | PF3D7_1362300 | Pf3D7_13_v3 | 2493143 | + | 570 | 0.782 | -0.312 | 1.876 | 3.668 | 3.075 | 3.97e-03 | 7.25e-02 | -1.957 | conserved protein, unknown function | NA |
| 240 | PF3D7_1215900 | Pf3D7_12_v3 | 641552 | + | 1968 | 0.743 | 0.298 | 1.187 | 4.806 | 3.068 | 4.04e-03 | 7.35e-02 | -2.049 | serpentine receptor, putative | SR10 |
| 20 | PF3D7_0216400 | Pf3D7_02_v3 | 675431 | + | 2169 | 0.789 | 0.122 | 1.457 | 0.530 | 3.064 | 4.09e-03 | 7.37e-02 | -1.936 | vacuolar protein sorting-associated protein 45, putative | VPS45 |
| 172 | PF3D7_0932900 | Pf3D7_09_v3 | 1309467 | - | 477 | 0.939 | 0.530 | 1.349 | 2.103 | 3.065 | 4.08e-03 | 7.37e-02 | -1.933 | conserved Plasmodium protein, unknown function | NA |
| 292 | PF3D7_1326700 | Pf3D7_13_v3 | 1125280 | + | 1629 | 1.336 | 0.904 | 1.768 | 3.634 | 3.063 | 4.16e-03 | 7.46e-02 | -1.994 | conserved Apicomplexan protein, unknown function | NA |
| 160 | PF3D7_0907900 | Pf3D7_09_v3 | 367865 | - | 925 | -1.480 | -2.225 | -0.735 | 3.656 | -3.067 | 4.19e-03 | 7.48e-02 | -2.003 | peptide deformylase | |
| 333 | PF3D7_1434300 | Pf3D7_14_v3 | 1372903 | + | 1695 | -0.408 | -1.424 | 0.608 | 8.746 | -3.050 | 4.25e-03 | 7.55e-02 | -2.345 | Hsp70/Hsp90 organizing protein | HOP |
| 353 | PF3D7_1462800 | Pf3D7_14_v3 | 2559098 | + | 1250 | -0.693 | -1.932 | 0.546 | 13.081 | -3.050 | 4.27e-03 | 7.56e-02 | -2.357 | glyceraldehyde-3-phosphate dehydrogenase | GAPDH |
| 5 | PF3D7_0108500 | Pf3D7_01_v3 | 349170 | + | 540 | -0.875 | -2.335 | 0.586 | 10.163 | -3.051 | 4.39e-03 | 7.58e-02 | -2.374 | conserved Plasmodium protein, unknown function | NA |
| 10 | PF3D7_0200100 | Pf3D7_02_v3 | 25232 | + | 5937 | -1.299 | -2.059 | -0.540 | 3.963 | -3.049 | 4.33e-03 | 7.58e-02 | -2.040 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 214 | PF3D7_1122300 | Pf3D7_11_v3 | 846929 | + | 1086 | 0.944 | 0.421 | 1.466 | 3.809 | 3.043 | 4.32e-03 | 7.58e-02 | -2.043 | conserved Plasmodium protein, unknown function | NA |
| 215 | PF3D7_1122900 | Pf3D7_11_v3 | 878969 | + | 16305 | -1.086 | -1.508 | -0.664 | 1.411 | -3.039 | 4.37e-03 | 7.58e-02 | -1.987 | dynein heavy chain, putative | NA |
| 254 | PF3D7_1233100 | Pf3D7_12_v3 | 1359169 | + | 408 | -0.794 | -1.469 | -0.119 | 4.068 | -3.041 | 4.35e-03 | 7.58e-02 | -2.047 | conserved protein, unknown function | NA |
| 270 | PF3D7_1253100 | Pf3D7_12_v3 | 2171342 | + | 1008 | 0.614 | 0.151 | 1.077 | 6.992 | 3.039 | 4.37e-03 | 7.58e-02 | -2.289 | Plasmodium exported protein (PHISTa), unknown function | NA |
| 115 | PF3D7_0709600 | Pf3D7_07_v3 | 429857 | - | 3902 | -0.489 | -0.848 | -0.129 | 7.337 | -3.035 | 4.41e-03 | 7.59e-02 | -2.319 | ribonucleases P/MRP protein subunit POP1, putative | POP1 |
| 223 | PF3D7_1133700 | Pf3D7_11_v3 | 1302173 | + | 3815 | -0.680 | -1.110 | -0.249 | 10.033 | -3.034 | 4.46e-03 | 7.60e-02 | -2.405 | FHA domain-containing protein, putative | NA |
| 264 | PF3D7_1244800 | Pf3D7_12_v3 | 1873194 | - | 2094 | -0.452 | -2.303 | 1.399 | 7.567 | -3.030 | 4.48e-03 | 7.60e-02 | -2.349 | cytoplasmic translation machinery associated protein, putative | NA |
| 269 | PF3D7_1251400 | Pf3D7_12_v3 | 2097436 | - | 1410 | 1.035 | 0.691 | 1.379 | 1.657 | 3.031 | 4.46e-03 | 7.60e-02 | -2.003 | conserved Plasmodium protein, unknown function | NA |
| 48 | PF3D7_0415300 | Pf3D7_04_v3 | 681810 | + | 4159 | -0.547 | -0.925 | -0.169 | 8.627 | -3.020 | 4.59e-03 | 7.68e-02 | -2.412 | cdc2-related protein kinase 3 | CRK3 |
| 108 | PF3D7_0703200 | Pf3D7_07_v3 | 122513 | - | 4623 | -0.955 | -1.527 | -0.383 | 4.508 | -3.017 | 4.63e-03 | 7.68e-02 | -2.149 | conserved Plasmodium protein, unknown function | NA |
| 118 | PF3D7_0712000 | Pf3D7_07_v3 | 527338 | - | 7794 | -1.572 | -1.966 | -1.178 | 3.236 | -3.029 | 4.61e-03 | 7.68e-02 | -2.056 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 155 | PF3D7_0833500 | Pf3D7_08_v3 | 1435794 | - | 7656 | -0.978 | -1.408 | -0.547 | 4.340 | -3.022 | 4.57e-03 | 7.68e-02 | -2.118 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 188 | PF3D7_1023000 | Pf3D7_10_v3 | 961066 | - | 1242 | 0.838 | 0.065 | 1.610 | 1.337 | 3.016 | 4.65e-03 | 7.68e-02 | -2.034 | conserved Plasmodium membrane protein, unknown function | NA |
| 300 | PF3D7_1347500 | Pf3D7_13_v3 | 1897983 | - | 1380 | -0.472 | -0.748 | -0.196 | 12.054 | -3.015 | 4.65e-03 | 7.68e-02 | -2.447 | DNA/RNA-binding protein Alba 4 | ALBA4 |
| 318 | PF3D7_1404900 | Pf3D7_14_v3 | 170000 | + | 894 | 0.405 | -0.046 | 0.855 | 8.338 | 3.020 | 4.59e-03 | 7.68e-02 | -2.403 | conserved Plasmodium protein, unknown function | NA |
| 92 | PF3D7_0613600 | Pf3D7_06_v3 | 554457 | + | 3772 | 1.236 | 0.284 | 2.188 | 0.053 | 3.009 | 4.73e-03 | 7.71e-02 | -2.057 | conserved Plasmodium protein, unknown function | NA |
| 125 | PF3D7_0716000 | Pf3D7_07_v3 | 703207 | + | 3378 | -0.490 | -0.849 | -0.130 | 8.568 | -3.008 | 4.74e-03 | 7.71e-02 | -2.441 | RNA-binding protein, putative | NA |
| 167 | PF3D7_0923100 | Pf3D7_09_v3 | 941830 | - | 669 | 1.113 | 0.506 | 1.720 | 1.302 | 3.009 | 4.73e-03 | 7.71e-02 | -2.049 | OTU domain-containing protein, putative | NA |
| 239 | PF3D7_1214600 | Pf3D7_12_v3 | 613561 | - | 1014 | -0.563 | -1.043 | -0.084 | 4.766 | -3.012 | 4.70e-03 | 7.71e-02 | -2.173 | adrenodoxin-type ferredoxin, putative | NA |
| 100 | PF3D7_0625400 | Pf3D7_06_v3 | 1032536 | - | 1239 | 0.554 | -0.780 | 1.888 | 7.778 | 3.005 | 4.77e-03 | 7.73e-02 | -2.409 | conserved Plasmodium protein, unknown function | NA |
| 79 | PF3D7_0528100 | Pf3D7_05_v3 | 1157840 | - | 3714 | -0.377 | -1.096 | 0.342 | 9.370 | -2.997 | 4.88e-03 | 7.81e-02 | -2.484 | AP-1 complex subunit beta, putative | NA |
| 191 | PF3D7_1025500 | Pf3D7_10_v3 | 1067652 | - | 19341 | -1.108 | -1.901 | -0.316 | 0.450 | -2.998 | 4.86e-03 | 7.81e-02 | -2.075 | conserved Plasmodium protein, unknown function | NA |
| 194 | PF3D7_1030100 | Pf3D7_10_v3 | 1224519 | - | 4574 | -0.406 | -1.677 | 0.865 | 8.759 | -2.997 | 4.88e-03 | 7.81e-02 | -2.471 | pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative | PRP22 |
| 77 | PF3D7_0527500 | Pf3D7_05_v3 | 1143618 | + | 1742 | -0.398 | -1.848 | 1.052 | 9.586 | -2.992 | 4.94e-03 | 7.83e-02 | -2.498 | Hsc70-interacting protein | HIP |
| 131 | PF3D7_0724000 | Pf3D7_07_v3 | 1006335 | + | 5811 | 0.875 | 0.418 | 1.332 | 2.241 | 2.994 | 4.92e-03 | 7.83e-02 | -2.092 | Rab GTPase activator and protein kinase, putative | NA |
| 268 | PF3D7_1250800 | Pf3D7_12_v3 | 2077718 | + | 5170 | -0.475 | -0.773 | -0.177 | 6.852 | -2.991 | 4.95e-03 | 7.83e-02 | -2.396 | DNA repair protein rhp16, putative | NA |
| 340 | PF3D7_1446300 | Pf3D7_14_v3 | 1898351 | + | 3576 | 1.129 | 0.535 | 1.724 | 4.066 | 2.990 | 5.01e-03 | 7.90e-02 | -2.187 | conserved Plasmodium membrane protein, unknown function | NA |
| 179 | PF3D7_1011800 | Pf3D7_10_v3 | 455398 | + | 3420 | -0.579 | -1.305 | 0.146 | 10.624 | -2.984 | 5.04e-03 | 7.92e-02 | -2.524 | PRE-binding protein | PREBP |
| 274 | PF3D7_1302900 | Pf3D7_13_v3 | 154992 | + | 2403 | 1.025 | 0.147 | 1.903 | 3.537 | 2.980 | 5.10e-03 | 7.98e-02 | -2.173 | conserved Plasmodium protein, unknown function | NA |
| 235 | PF3D7_1208600 | Pf3D7_12_v3 | 402300 | + | 228 | -0.700 | -1.229 | -0.171 | 3.757 | -2.977 | 5.15e-03 | 8.00e-02 | -2.202 | mitochondrial import inner membrane translocase subunit TIM10, putative | TIM10 |
| 284 | PF3D7_1309600 | Pf3D7_13_v3 | 438510 | + | 867 | 0.727 | 0.325 | 1.129 | 4.309 | 2.976 | 5.15e-03 | 8.00e-02 | -2.223 | ribosomal RNA methyltransferase, putative | NA |
| 11 | PF3D7_0201600 | Pf3D7_02_v3 | 77251 | - | 1558 | -0.649 | -1.469 | 0.172 | 9.150 | -2.971 | 5.23e-03 | 8.01e-02 | -2.527 | PHISTb domain-containing RESA-like protein 1 | RLP1 |
| 18 | PF3D7_0211800 | Pf3D7_02_v3 | 475242 | + | 1833 | -0.643 | -1.218 | -0.068 | 9.283 | -2.961 | 5.37e-03 | 8.01e-02 | -2.569 | asparagine–tRNA ligase | AsnRS |
| 97 | PF3D7_0621300 | Pf3D7_06_v3 | 873809 | + | 2382 | 0.443 | -0.422 | 1.307 | 7.592 | 2.960 | 5.37e-03 | 8.01e-02 | -2.512 | mRNA binding Pumilio-homology domain protein, putative | NA |
| 129 | PF3D7_0719900 | Pf3D7_07_v3 | 865927 | + | 10206 | -0.417 | -1.081 | 0.248 | 7.724 | -2.959 | 5.39e-03 | 8.01e-02 | -2.527 | conserved Plasmodium membrane protein, unknown function | NA |
| 135 | PF3D7_0801700 | Pf3D7_08_v3 | 112299 | + | 5579 | -0.589 | -0.932 | -0.246 | 6.129 | -2.966 | 5.29e-03 | 8.01e-02 | -2.402 | sentrin-specific protease 2, putative | SENP2 |
| 137 | PF3D7_0804700 | Pf3D7_08_v3 | 271417 | - | 5997 | -0.573 | -1.463 | 0.317 | 5.755 | -2.962 | 5.34e-03 | 8.01e-02 | -2.376 | conserved Plasmodium protein, unknown function | NA |
| 159 | PF3D7_0907700 | Pf3D7_09_v3 | 364069 | - | 840 | 0.415 | 0.186 | 0.645 | 7.929 | 2.970 | 5.23e-03 | 8.01e-02 | -2.506 | subunit of proteaseome activator complex, putative | PA28 |
| 217 | PF3D7_1124100 | Pf3D7_11_v3 | 951382 | - | 4962 | -0.411 | -0.946 | 0.123 | 8.014 | -2.963 | 5.34e-03 | 8.01e-02 | -2.532 | beige/BEACH domain protein, putative | NA |
| 256 | PF3D7_1235300 | Pf3D7_12_v3 | 1470713 | + | 4989 | -0.568 | -1.359 | 0.222 | 9.292 | -2.966 | 5.29e-03 | 8.01e-02 | -2.553 | CCR4-NOT transcription complex subunit 4, putative | NOT4 |
| 301 | PF3D7_1350100 | Pf3D7_13_v3 | 2005962 | - | 1989 | -0.430 | -1.427 | 0.567 | 9.206 | -2.962 | 5.34e-03 | 8.01e-02 | -2.565 | lysine–tRNA ligase | KRS1 |
| 312 | PF3D7_1366500 | Pf3D7_13_v3 | 2661573 | + | 450 | 1.090 | 0.675 | 1.506 | 0.730 | 2.968 | 5.26e-03 | 8.01e-02 | -2.136 | nucleoside diphosphate kinase | NDK |
| 350 | PF3D7_1458000 | Pf3D7_14_v3 | 2387786 | + | 1710 | 0.339 | -0.118 | 0.796 | 8.196 | 2.974 | 5.19e-03 | 8.01e-02 | -2.506 | cysteine proteinase falcipain 1 | FP1 |
| 61 | PF3D7_0502500 | Pf3D7_05_v3 | 114149 | + | 1785 | 1.611 | 0.861 | 2.360 | 0.201 | 2.957 | 5.42e-03 | 8.02e-02 | -2.162 | conserved Plasmodium protein, unknown function | NA |
| 354 | PF3D7_1466300 | Pf3D7_14_v3 | 2709418 | + | 3775 | -0.392 | -1.138 | 0.353 | 9.366 | -2.954 | 5.46e-03 | 8.05e-02 | -2.587 | 26S proteasome regulatory subunit RPN2, putative | RPN2 |
| 151 | PF3D7_0826900 | Pf3D7_08_v3 | 1164655 | + | 2551 | 0.987 | 0.185 | 1.788 | 3.078 | 2.949 | 5.54e-03 | 8.14e-02 | -2.213 | conserved Plasmodium protein, unknown function | NA |
| 80 | PF3D7_0528800 | Pf3D7_05_v3 | 1180425 | - | 1614 | 0.476 | -0.329 | 1.281 | 6.073 | 2.942 | 5.64e-03 | 8.23e-02 | -2.448 | nucleolar preribosomal GTPase, putative | NA |
| 257 | PF3D7_1239800 | Pf3D7_12_v3 | 1660451 | + | 17304 | -1.106 | -1.531 | -0.682 | 3.686 | -2.944 | 5.62e-03 | 8.23e-02 | -2.271 | conserved Plasmodium protein, unknown function | NA |
| 39 | PF3D7_0404300 | Pf3D7_04_v3 | 234014 | - | 3000 | -0.853 | -1.708 | 0.001 | 7.533 | -2.947 | 5.68e-03 | 8.23e-02 | -2.553 | conserved Plasmodium protein, unknown function | NA |
| 185 | PF3D7_1019100 | Pf3D7_10_v3 | 766168 | - | 5787 | -1.392 | -1.726 | -1.058 | 0.749 | -2.939 | 5.67e-03 | 8.23e-02 | -2.197 | conserved Plasmodium protein, unknown function | NA |
| 304 | PF3D7_1355200 | Pf3D7_13_v3 | 2191058 | - | 3054 | 1.630 | 0.890 | 2.370 | 0.536 | 2.939 | 5.71e-03 | 8.24e-02 | -2.201 | RAP protein, putative | NA |
| 328 | PF3D7_1424500 | Pf3D7_14_v3 | 979464 | + | 142 | -0.825 | -1.714 | 0.063 | 3.590 | -2.929 | 5.82e-03 | 8.37e-02 | -2.269 | small nucleolar RNA snoR27 | NA |
| 293 | PF3D7_1338600 | Pf3D7_13_v3 | 1556659 | - | 3076 | 1.267 | 0.697 | 1.837 | 0.039 | 2.928 | 5.85e-03 | 8.39e-02 | -2.224 | conserved Plasmodium protein, unknown function | NA |
| 311 | PF3D7_1366000 | Pf3D7_13_v3 | 2635213 | + | 276 | 1.117 | 0.785 | 1.450 | 2.202 | 2.924 | 5.91e-03 | 8.45e-02 | -2.245 | conserved Plasmodium protein, unknown function | NA |
| 236 | PF3D7_1210300 | Pf3D7_12_v3 | 465115 | + | 630 | 0.713 | -0.071 | 1.498 | 3.554 | 2.919 | 5.97e-03 | 8.51e-02 | -2.306 | conserved Plasmodium protein, unknown function | NA |
| 249 | PF3D7_1228900 | Pf3D7_12_v3 | 1180670 | - | 4814 | -0.607 | -1.072 | -0.142 | 6.434 | -2.916 | 6.03e-03 | 8.56e-02 | -2.543 | conserved Plasmodium protein, unknown function | NA |
| 8 | PF3D7_0115200 | Pf3D7_01_v3 | 591849 | + | 1339 | -2.053 | -3.146 | -0.961 | -0.691 | -2.917 | 6.08e-03 | 8.59e-02 | -2.273 | rifin | RIF |
| 30 | PF3D7_0311700 | Pf3D7_03_v3 | 502698 | + | 3151 | -1.459 | -2.316 | -0.601 | 0.983 | -2.910 | 6.12e-03 | 8.59e-02 | -2.258 | plasmepsin VI | NA |
| 46 | PF3D7_0412900 | Pf3D7_04_v3 | 576810 | - | 7859 | -1.189 | -1.516 | -0.862 | 2.611 | -2.911 | 6.10e-03 | 8.59e-02 | -2.281 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 43 | PF3D7_0411900 | Pf3D7_04_v3 | 528192 | - | 6294 | -0.914 | -1.287 | -0.541 | 1.934 | -2.905 | 6.20e-03 | 8.62e-02 | -2.285 | DNA polymerase alpha catalytic subunit A | NA |
| 201 | PF3D7_1102700 | Pf3D7_11_v3 | 128789 | + | 276 | -0.587 | -0.982 | -0.192 | 10.475 | -2.905 | 6.20e-03 | 8.62e-02 | -2.712 | early transcribed membrane protein 11.1 | ETRAMP11.1 |
| 279 | PF3D7_1306400 | Pf3D7_13_v3 | 297178 | - | 1182 | -0.466 | -1.327 | 0.396 | 7.247 | -2.904 | 6.22e-03 | 8.62e-02 | -2.620 | 26S protease regulatory subunit 10B, putative | RPT4 |
| 302 | PF3D7_1353500 | Pf3D7_13_v3 | 2144125 | + | 981 | 0.778 | 0.133 | 1.423 | 3.030 | 2.907 | 6.17e-03 | 8.62e-02 | -2.310 | RNA polymerase II transcription factor B subunit 4, putative | TFB4 |
| 2 | mal_rna_17:rRNA | M76611 | 5577 | - | 195 | -1.264 | -1.671 | -0.857 | 4.223 | -2.903 | 6.33e-03 | 8.72e-02 | -2.368 | NA | NA |
| 196 | PF3D7_1037900 | Pf3D7_10_v3 | 1502955 | - | 1368 | 1.025 | 0.342 | 1.708 | 2.136 | 2.897 | 6.34e-03 | 8.72e-02 | -2.305 | conserved Plasmodium protein, unknown function | NA |
| 164 | PF3D7_0915100 | Pf3D7_09_v3 | 643232 | - | 812 | -0.531 | -1.152 | 0.090 | 6.543 | -2.889 | 6.46e-03 | 8.87e-02 | -2.613 | SUMO-conjugating enzyme UBC9 | UBC9 |
| 35 | PF3D7_0323000 | Pf3D7_03_v3 | 968675 | - | 528 | -0.901 | -1.197 | -0.604 | 4.269 | -2.885 | 6.53e-03 | 8.91e-02 | -2.451 | translation machinery-associated protein 7, putative | TMA7 |
| 309 | PF3D7_1365000 | Pf3D7_13_v3 | 2608698 | + | 1047 | -0.839 | -1.102 | -0.577 | 3.815 | -2.886 | 6.52e-03 | 8.91e-02 | -2.383 | conserved Plasmodium protein, unknown function | NA |
| 60 | PF3D7_0501400 | Pf3D7_05_v3 | 74509 | + | 5334 | -1.045 | -1.303 | -0.787 | 10.998 | -2.901 | 6.65e-03 | 8.95e-02 | -2.750 | interspersed repeat antigen | FIRA |
| 75 | PF3D7_0523700 | Pf3D7_05_v3 | 980754 | - | 4601 | 1.308 | 0.350 | 2.266 | 0.920 | 2.876 | 6.69e-03 | 8.95e-02 | -2.330 | conserved Plasmodium membrane protein, unknown function | NA |
| 86 | PF3D7_0601600 | Pf3D7_06_v3 | 68833 | - | 861 | 1.227 | -0.183 | 2.636 | 1.035 | 2.873 | 6.74e-03 | 8.95e-02 | -2.336 | tetratricopeptide repeat protein, putative | NA |
| 93 | PF3D7_0613900 | Pf3D7_06_v3 | 579435 | - | 6462 | 1.190 | -0.386 | 2.767 | 0.943 | 2.874 | 6.72e-03 | 8.95e-02 | -2.333 | myosin E, putative | myoE |
| 96 | PF3D7_0618200 | Pf3D7_06_v3 | 764667 | - | 826 | -0.533 | -1.152 | 0.086 | 7.015 | -2.871 | 6.78e-03 | 8.95e-02 | -2.694 | conserved Plasmodium protein, unknown function | NA |
| 101 | PF3D7_0625600 | Pf3D7_06_v3 | 1039655 | + | 1896 | 0.840 | -0.298 | 1.979 | 5.615 | 2.878 | 6.67e-03 | 8.95e-02 | -2.558 | poly(A) polymerase PAP, putative | NA |
| 163 | PF3D7_0913200 | Pf3D7_09_v3 | 575679 | + | 831 | -0.503 | -1.221 | 0.215 | 8.866 | -2.871 | 6.77e-03 | 8.95e-02 | -2.774 | elongation factor 1-beta | EF-1beta |
| 228 | PF3D7_1142400 | Pf3D7_11_v3 | 1702089 | - | 1554 | 0.593 | -0.547 | 1.732 | 5.970 | 2.878 | 6.64e-03 | 8.95e-02 | -2.595 | coproporphyrinogen-III oxidase | CPO |
| 276 | PF3D7_1303100 | Pf3D7_13_v3 | 159024 | + | 892 | -0.764 | -1.043 | -0.485 | 3.651 | -2.879 | 6.62e-03 | 8.95e-02 | -2.425 | methyltransferase-like protein, putative | NA |
| 334 | PF3D7_1436500 | Pf3D7_14_v3 | 1488706 | + | 1296 | 1.054 | 0.135 | 1.972 | 0.183 | 2.873 | 6.73e-03 | 8.95e-02 | -2.336 | GTP-binding protein, putative | NA |
| 110 | PF3D7_0703700 | Pf3D7_07_v3 | 146645 | - | 750 | 0.495 | -0.380 | 1.370 | 7.579 | 2.868 | 6.82e-03 | 8.98e-02 | -2.726 | conserved Plasmodium protein, unknown function | NA |
| 171 | PF3D7_0931400 | Pf3D7_09_v3 | 1263347 | + | 1484 | -0.845 | -1.123 | -0.567 | 3.547 | -2.862 | 6.93e-03 | 9.00e-02 | -2.427 | conserved Plasmodium protein, unknown function | NA |
| 206 | PF3D7_1108600 | Pf3D7_11_v3 | 369675 | - | 1032 | -0.677 | -1.052 | -0.302 | 9.227 | -2.866 | 6.92e-03 | 9.00e-02 | -2.788 | endoplasmic reticulum-resident calcium binding protein | ERC |
| 306 | PF3D7_1360100 | Pf3D7_13_v3 | 2405249 | - | 969 | -0.524 | -0.778 | -0.270 | 5.582 | -2.864 | 6.88e-03 | 9.00e-02 | -2.577 | RNA-binding protein, putative | NA |
| 329 | PF3D7_1426000 | Pf3D7_14_v3 | 1016133 | - | 486 | 0.490 | 0.116 | 0.864 | 8.627 | 2.863 | 6.90e-03 | 9.00e-02 | -2.783 | 60S ribosomal protein L21 | RPL21 |
| 15 | PF3D7_0202500 | Pf3D7_02_v3 | 127994 | + | 321 | -0.663 | -1.051 | -0.275 | 12.139 | -2.862 | 6.99e-03 | 9.04e-02 | -2.815 | early transcribed membrane protein 2 | ETRAMP2 |
| 157 | PF3D7_0903100 | Pf3D7_09_v3 | 130140 | - | 798 | 0.695 | 0.070 | 1.319 | 4.700 | 2.858 | 7.00e-03 | 9.04e-02 | -2.518 | protein RER1, putative | RER1 |
| 21 | PF3D7_0218700 | Pf3D7_02_v3 | 763491 | - | 1701 | -0.606 | -1.170 | -0.042 | 7.123 | -2.852 | 7.11e-03 | 9.05e-02 | -2.732 | pre-mRNA-processing protein 45, putative | PRP45 |
| 150 | PF3D7_0826100 | Pf3D7_08_v3 | 1113369 | - | 25776 | -0.526 | -0.989 | -0.064 | 10.275 | -2.853 | 7.08e-03 | 9.05e-02 | -2.833 | E3 ubiquitin-protein ligase, putative | NA |
| 192 | PF3D7_1027300 | Pf3D7_10_v3 | 1140589 | - | 2014 | -0.763 | -1.045 | -0.481 | 8.469 | -2.857 | 7.12e-03 | 9.05e-02 | -2.792 | peroxiredoxin | nPrx |
| 250 | PF3D7_1229600 | Pf3D7_12_v3 | 1214043 | - | 3673 | -1.015 | -1.610 | -0.421 | 1.452 | -2.855 | 7.06e-03 | 9.05e-02 | -2.377 | conserved Plasmodium protein, unknown function | NA |
| 266 | PF3D7_1247400 | Pf3D7_12_v3 | 1955124 | - | 915 | -0.628 | -1.393 | 0.137 | 6.237 | -2.853 | 7.10e-03 | 9.05e-02 | -2.670 | peptidyl-prolyl cis-trans isomerase FKBP35 | FKBP35 |
| 78 | PF3D7_0528000 | Pf3D7_05_v3 | 1156205 | - | 375 | 0.784 | -1.169 | 2.738 | 3.675 | 2.849 | 7.17e-03 | 9.08e-02 | -2.468 | proteasome maturation factor UMP1, putative | UMP1 |
| 91 | PF3D7_0612700 | Pf3D7_06_v3 | 525987 | - | 1044 | 0.819 | -0.189 | 1.826 | 1.993 | 2.847 | 7.20e-03 | 9.08e-02 | -2.403 | 6-cysteine protein | P12 |
| 325 | PF3D7_1417700 | Pf3D7_14_v3 | 750330 | + | 1355 | -0.593 | -0.956 | -0.231 | 4.828 | -2.846 | 7.21e-03 | 9.08e-02 | -2.560 | conserved Plasmodium protein, unknown function | NA |
| 49 | PF3D7_0416000 | Pf3D7_04_v3 | 701526 | - | 2637 | -0.691 | -1.273 | -0.108 | 6.293 | -2.845 | 7.24e-03 | 9.09e-02 | -2.692 | RNA-binding protein, putative | NA |
| 26 | PF3D7_0303400 | Pf3D7_03_v3 | 178420 | + | 2708 | 1.000 | 0.628 | 1.372 | 1.354 | 2.833 | 7.46e-03 | 9.26e-02 | -2.422 | palmitoyltransferase DHHC1 | DHHC1 |
| 158 | PF3D7_0905300 | Pf3D7_09_v3 | 251353 | - | 18357 | -0.896 | -1.244 | -0.548 | 2.709 | -2.834 | 7.44e-03 | 9.26e-02 | -2.463 | dynein heavy chain, putative | NA |
| 208 | PF3D7_1111000 | Pf3D7_11_v3 | 434802 | + | 1740 | 0.564 | -0.224 | 1.352 | 5.391 | 2.833 | 7.46e-03 | 9.26e-02 | -2.639 | tRNA m5C-methyltransferase, putative | NA |
| 327 | PF3D7_1423200 | Pf3D7_14_v3 | 933059 | + | 2299 | -0.588 | -0.881 | -0.294 | 5.853 | -2.834 | 7.45e-03 | 9.26e-02 | -2.687 | peptidyl-prolyl cis-trans isomerase | CYP52 |
| 74 | PF3D7_0523300 | Pf3D7_05_v3 | 970266 | - | 697 | 1.001 | 0.197 | 1.805 | 0.700 | 2.826 | 7.59e-03 | 9.29e-02 | -2.430 | conserved Plasmodium protein, unknown function | NA |
| 176 | PF3D7_1002300 | Pf3D7_10_v3 | 117242 | + | 1293 | 0.867 | 0.028 | 1.706 | 1.347 | 2.827 | 7.58e-03 | 9.29e-02 | -2.436 | conserved Plasmodium protein, unknown function | NA |
| 290 | PF3D7_1322100 | Pf3D7_13_v3 | 920971 | + | 8479 | -0.528 | -1.188 | 0.132 | 9.385 | -2.826 | 7.59e-03 | 9.29e-02 | -2.877 | histone-lysine N-methyltransferase SET2 | SET2 |
| 294 | PF3D7_1341100 | Pf3D7_13_v3 | 1632602 | - | 108 | -1.102 | -1.788 | -0.415 | 3.017 | -2.826 | 7.60e-03 | 9.29e-02 | -2.474 | U6 spliceosomal RNA | NA |
| 314 | PF3D7_1373500 | Pf3D7_13_v3 | 2884786 | - | 7555 | -0.781 | -1.245 | -0.318 | 4.450 | -2.826 | 7.60e-03 | 9.29e-02 | -2.568 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 245 | PF3D7_1225200 | Pf3D7_12_v3 | 1024455 | - | 3564 | 0.382 | -0.352 | 1.116 | 6.893 | 2.824 | 7.64e-03 | 9.32e-02 | -2.789 | conserved Plasmodium protein, unknown function | NA |
| 63 | PF3D7_0506700 | Pf3D7_05_v3 | 280886 | + | 2460 | -0.562 | -1.252 | 0.128 | 4.982 | -2.815 | 7.81e-03 | 9.49e-02 | -2.656 | GTPase-activating protein, putative | NA |
| 219 | PF3D7_1126100 | Pf3D7_11_v3 | 1018366 | - | 4130 | 0.858 | 0.339 | 1.377 | 1.600 | 2.811 | 7.90e-03 | 9.57e-02 | -2.473 | autophagy-related protein 7, putative | ATG7 |
| 88 | PF3D7_0607000 | Pf3D7_06_v3 | 293864 | + | 2934 | -0.447 | -1.635 | 0.742 | 10.481 | -2.807 | 7.97e-03 | 9.61e-02 | -2.942 | translation initiation factor IF-2, putative | NA |
| 94 | PF3D7_0614200 | Pf3D7_06_v3 | 593172 | - | 2733 | 0.813 | -0.615 | 2.241 | 3.914 | 2.807 | 7.98e-03 | 9.61e-02 | -2.578 | cytosolic Fe-S cluster assembly factor NAR1, putative | NAR1 |
| 140 | PF3D7_0808600 | Pf3D7_08_v3 | 431165 | + | 7887 | -0.842 | -1.341 | -0.344 | 4.353 | -2.804 | 8.04e-03 | 9.66e-02 | -2.618 | erythrocyte membrane protein 1, PfEMP1 | VAR |
| 126 | PF3D7_0717400 | Pf3D7_07_v3 | 751877 | + | 2256 | -0.411 | -1.105 | 0.283 | 7.621 | -2.802 | 8.08e-03 | 9.67e-02 | -2.882 | queuine tRNA-ribosyltransferase, putative | NA |
| 332 | PF3D7_1431600 | Pf3D7_14_v3 | 1244018 | + | 1389 | 1.118 | 0.219 | 2.016 | 1.156 | 2.798 | 8.15e-03 | 9.74e-02 | -2.492 | succinyl-CoA ligase [ADP-forming] subunit beta, putative | NA |
| 38 | PF3D7_0400200 | Pf3D7_04_v3 | 38955 | + | 1200 | -1.094 | -1.337 | -0.852 | 2.992 | -2.789 | 8.34e-03 | 9.86e-02 | -2.559 | erythrocyte membrane protein 1 (PfEMP1), exon 2, pseudogene | NA |
| 89 | PF3D7_0608700 | Pf3D7_06_v3 | 358391 | + | 1813 | -0.362 | -0.916 | 0.193 | 9.108 | -2.789 | 8.35e-03 | 9.86e-02 | -2.970 | T-complex protein 1 subunit zeta | CCT6 |
| 344 | PF3D7_1450300 | Pf3D7_14_v3 | 2056641 | + | 2598 | 0.766 | 0.095 | 1.436 | 5.175 | 2.789 | 8.35e-03 | 9.86e-02 | -2.736 | NADPH–cytochrome P450 reductase, putative | CPR |
| 351 | PF3D7_1459300 | Pf3D7_14_v3 | 2432177 | + | 570 | 0.803 | 0.428 | 1.178 | 1.803 | 2.789 | 8.35e-03 | 9.86e-02 | -2.526 | OPA3-like protein, putative | NA |
| 320 | PF3D7_1412700 | Pf3D7_14_v3 | 512363 | + | 3660 | -0.569 | -1.258 | 0.119 | 5.935 | -2.787 | 8.40e-03 | 9.89e-02 | -2.794 | AAA family ATPase, putative | NA |
| 113 | PF3D7_0707900 | Pf3D7_07_v3 | 366929 | + | 780 | -0.414 | -1.143 | 0.315 | 7.553 | -2.784 | 8.46e-03 | 9.90e-02 | -2.921 | ribosomal protein S8e, putative | NA |
| 261 | PF3D7_1244100 | Pf3D7_12_v3 | 1847677 | + | 4480 | -0.482 | -0.753 | -0.210 | 5.912 | -2.781 | 8.53e-03 | 9.90e-02 | -2.809 | N-alpha-acetyltransferase 15, NatA auxiliary subunit, putative | NA |
| 321 | PF3D7_1414100 | Pf3D7_14_v3 | 560093 | + | 2232 | 0.548 | -0.272 | 1.368 | 6.992 | 2.781 | 8.51e-03 | 9.90e-02 | -2.891 | conserved Plasmodium protein, unknown function | NA |
| 336 | PF3D7_1439100 | Pf3D7_14_v3 | 1580750 | + | 8108 | -0.574 | -0.972 | -0.177 | 6.512 | -2.782 | 8.50e-03 | 9.90e-02 | -2.857 | DEAD/DEAH box helicase, putative | NA |
| 342 | PF3D7_1447200 | Pf3D7_14_v3 | 1933985 | + | 1791 | -0.429 | -0.856 | -0.001 | 7.819 | -2.781 | 8.52e-03 | 9.90e-02 | -2.944 | conserved Plasmodium protein, unknown function | NA |
| 253 | PF3D7_1232200 | Pf3D7_12_v3 | 1333134 | + | 1763 | -0.941 | -1.961 | 0.079 | 0.865 | -2.777 | 8.60e-03 | 9.95e-02 | -2.533 | dihydrolipoyl dehydrogenase, mitochondrial | LPD1 |
col_annot <- data.frame(row.names = colnames(v$E), stringsAsFactors = F)
col_annot$phenotype[substring(colnames(v$E), 1, 1) == "I"] <- "non-severe"
col_annot$phenotype[substring(colnames(v$E), 1, 1) == "S"] <- "severe"
col_annot$phenotype <- as.factor(col_annot$phenotype)
pheatmap(v2$E[rownames(v$E) %in% top_ring_ruv$GeneID, ], show_rownames = FALSE, scale = "row", annotation_col = col_annot, annotation_colors = list(phenotype = c(`non-severe` = colors[1],
severe = colors[2])))
First GO set enrichment using limma’s mroast.
# genesets <- AnnotationDbi::select(org.Pf.plasmo.db, keys=top_ring_ruv$GeneID, keytype='ALIAS', columns = c('GO','PATH')) go.gene.sets <-
# lapply(split.data.frame(genesets,genesets$GO), function(x) as.vector(x$ALIAS)) kegg.gene.sets <- lapply(split.data.frame(genesets,genesets$PATH),
# function(x) as.vector(x$ALIAS))
MIN_SET_SIZE <- 3
go.gene.df <- fread("./data/go_gene_lists.txt", sep = "\t", data.table = FALSE)
go.gene.sets <- lapply(go.gene.df$Genes, function(x) {
x <- unlist(str_split(x, ","))
x <- x[x != ""]
})
names(go.gene.sets) <- go.gene.df$GO_ID
go.gene.sets <- go.gene.sets[unlist(lapply(go.gene.sets, length)) >= MIN_SET_SIZE]
kegg.gene.df <- fread("./data/kegg_gene_lists.txt", sep = "\t", data.table = FALSE)
kegg.gene.sets <- lapply(kegg.gene.df$Genes, function(x) {
x <- unlist(str_split(x, ","))
x <- x[x != ""]
})
names(kegg.gene.sets) <- kegg.gene.df$KEGG_ID
kegg.gene.sets <- kegg.gene.sets[unlist(lapply(kegg.gene.sets, length)) >= MIN_SET_SIZE]
indices <- ids2indices(go.gene.sets, rownames(v2), remove.empty = TRUE)
go_mr <- mroast(v2, index = indices, design = modRUV, contrast = 2, nrot = 10000, set.statistic = "floormean")
go_cam <- camera(v2, index = indices, design = modRUV, contrast = 2)
kable(go_mr, digits = 3)
| NGenes | PropDown | PropUp | Direction | PValue | FDR | PValue.Mixed | FDR.Mixed | |
|---|---|---|---|---|---|---|---|---|
| GO:0016337 | 54 | 0.852 | 0.019 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0098602 | 54 | 0.852 | 0.019 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0007155 | 69 | 0.696 | 0.014 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0020035 | 93 | 0.634 | 0.032 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0044406 | 93 | 0.634 | 0.032 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0034118 | 87 | 0.632 | 0.011 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0020013 | 87 | 0.632 | 0.011 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0030155 | 87 | 0.632 | 0.011 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0034110 | 87 | 0.632 | 0.011 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0022407 | 87 | 0.632 | 0.011 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0044068 | 88 | 0.625 | 0.011 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0051807 | 93 | 0.624 | 0.022 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0051834 | 93 | 0.624 | 0.022 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0051832 | 93 | 0.624 | 0.022 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0043207 | 93 | 0.624 | 0.022 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0052564 | 93 | 0.624 | 0.022 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0051805 | 93 | 0.624 | 0.022 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0052173 | 93 | 0.624 | 0.022 | Down | 0.000 | 0.001 | 0.000 | 0.003 |
| GO:0051809 | 92 | 0.620 | 0.022 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0020033 | 92 | 0.620 | 0.022 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0044003 | 89 | 0.618 | 0.011 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0051817 | 89 | 0.618 | 0.011 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0009607 | 94 | 0.617 | 0.021 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0035821 | 90 | 0.611 | 0.022 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0009605 | 100 | 0.610 | 0.030 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0022610 | 113 | 0.558 | 0.035 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0065008 | 149 | 0.456 | 0.107 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0044403 | 157 | 0.446 | 0.096 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0044419 | 157 | 0.446 | 0.096 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0051701 | 147 | 0.442 | 0.082 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0050896 | 291 | 0.357 | 0.096 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0065007 | 401 | 0.309 | 0.150 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0050794 | 359 | 0.309 | 0.142 | Down | 0.000 | 0.001 | 0.000 | 0.001 |
| GO:0009405 | 84 | 0.690 | 0.048 | Down | 0.000 | 0.004 | 0.000 | 0.003 |
| GO:0051704 | 189 | 0.444 | 0.095 | Down | 0.000 | 0.004 | 0.000 | 0.003 |
| GO:0050789 | 380 | 0.321 | 0.139 | Down | 0.000 | 0.004 | 0.000 | 0.001 |
| GO:0051707 | 93 | 0.624 | 0.022 | Down | 0.000 | 0.006 | 0.000 | 0.003 |
| GO:0009396 | 4 | 0.500 | 0.000 | Down | 0.000 | 0.006 | 0.002 | 0.008 |
| GO:0016579 | 11 | 0.545 | 0.182 | Down | 0.000 | 0.008 | 0.001 | 0.006 |
| GO:0006848 | 2 | 0.500 | 0.000 | Down | 0.000 | 0.008 | 0.001 | 0.006 |
| GO:0000245 | 9 | 0.667 | 0.111 | Down | 0.000 | 0.010 | 0.000 | 0.003 |
| GO:0070646 | 11 | 0.545 | 0.182 | Down | 0.000 | 0.010 | 0.001 | 0.006 |
| GO:0006760 | 5 | 0.400 | 0.200 | Down | 0.000 | 0.010 | 0.000 | 0.006 |
| GO:0031123 | 8 | 0.125 | 0.750 | Up | 0.001 | 0.012 | 0.001 | 0.006 |
| GO:0016485 | 10 | 0.500 | 0.000 | Down | 0.001 | 0.014 | 0.002 | 0.009 |
| GO:0031167 | 2 | 1.000 | 0.000 | Down | 0.001 | 0.016 | 0.001 | 0.006 |
| GO:0042026 | 3 | 0.667 | 0.000 | Down | 0.001 | 0.017 | 0.001 | 0.008 |
| GO:0051604 | 12 | 0.417 | 0.000 | Down | 0.001 | 0.017 | 0.004 | 0.013 |
| GO:0008154 | 1 | 1.000 | 0.000 | Down | 0.001 | 0.017 | 0.001 | 0.007 |
| GO:0006206 | 6 | 0.500 | 0.000 | Down | 0.001 | 0.017 | 0.004 | 0.014 |
| GO:0009112 | 7 | 0.429 | 0.000 | Down | 0.001 | 0.017 | 0.005 | 0.015 |
| GO:0019220 | 27 | 0.222 | 0.407 | Up | 0.001 | 0.017 | 0.000 | 0.001 |
| GO:0006950 | 91 | 0.286 | 0.165 | Down | 0.001 | 0.017 | 0.000 | 0.005 |
| GO:0006207 | 5 | 0.400 | 0.000 | Down | 0.001 | 0.022 | 0.012 | 0.026 |
| GO:0046112 | 5 | 0.400 | 0.000 | Down | 0.001 | 0.025 | 0.013 | 0.028 |
| GO:0048519 | 16 | 0.312 | 0.375 | Down | 0.001 | 0.025 | 0.000 | 0.004 |
| GO:0044699 | 809 | 0.235 | 0.178 | Down | 0.001 | 0.025 | 0.000 | 0.006 |
| GO:0006457 | 72 | 0.417 | 0.097 | Down | 0.002 | 0.025 | 0.001 | 0.006 |
| GO:0019856 | 5 | 0.400 | 0.000 | Down | 0.002 | 0.025 | 0.014 | 0.029 |
| GO:0007007 | 3 | 0.667 | 0.000 | Down | 0.002 | 0.027 | 0.005 | 0.015 |
| GO:0090151 | 3 | 0.667 | 0.000 | Down | 0.002 | 0.027 | 0.006 | 0.016 |
| GO:0071840 | 251 | 0.283 | 0.151 | Down | 0.002 | 0.027 | 0.001 | 0.007 |
| GO:0045039 | 3 | 0.667 | 0.000 | Down | 0.002 | 0.028 | 0.006 | 0.016 |
| GO:0051174 | 27 | 0.222 | 0.407 | Up | 0.002 | 0.028 | 0.000 | 0.006 |
| GO:0042325 | 5 | 0.000 | 0.800 | Up | 0.002 | 0.028 | 0.010 | 0.022 |
| GO:0043631 | 6 | 0.167 | 0.667 | Up | 0.002 | 0.028 | 0.002 | 0.009 |
| GO:0007006 | 3 | 0.667 | 0.000 | Down | 0.002 | 0.029 | 0.005 | 0.015 |
| GO:0006518 | 11 | 0.364 | 0.182 | Down | 0.002 | 0.030 | 0.003 | 0.011 |
| GO:0009260 | 18 | 0.111 | 0.333 | Up | 0.002 | 0.030 | 0.002 | 0.009 |
| GO:0001817 | 3 | 0.667 | 0.000 | Down | 0.002 | 0.031 | 0.002 | 0.010 |
| GO:0006730 | 4 | 0.500 | 0.250 | Down | 0.002 | 0.031 | 0.001 | 0.006 |
| GO:0006575 | 13 | 0.308 | 0.308 | Down | 0.002 | 0.031 | 0.001 | 0.006 |
| GO:0016568 | 18 | 0.389 | 0.167 | Down | 0.002 | 0.032 | 0.001 | 0.007 |
| GO:0016571 | 5 | 0.600 | 0.000 | Down | 0.003 | 0.034 | 0.002 | 0.010 |
| GO:0001932 | 5 | 0.000 | 0.800 | Up | 0.003 | 0.034 | 0.010 | 0.022 |
| GO:0031399 | 5 | 0.000 | 0.800 | Up | 0.003 | 0.034 | 0.010 | 0.023 |
| GO:0002098 | 4 | 0.000 | 0.500 | Up | 0.003 | 0.034 | 0.011 | 0.024 |
| GO:0008033 | 37 | 0.108 | 0.351 | Up | 0.003 | 0.035 | 0.001 | 0.007 |
| GO:0015914 | 4 | 0.250 | 0.250 | Down | 0.003 | 0.035 | 0.000 | 0.001 |
| GO:0042221 | 68 | 0.250 | 0.088 | Down | 0.003 | 0.036 | 0.002 | 0.008 |
| GO:0009152 | 17 | 0.118 | 0.353 | Up | 0.003 | 0.036 | 0.002 | 0.009 |
| GO:0044085 | 153 | 0.301 | 0.150 | Down | 0.003 | 0.037 | 0.001 | 0.007 |
| GO:0051239 | 3 | 0.667 | 0.000 | Down | 0.003 | 0.037 | 0.003 | 0.012 |
| GO:0009201 | 8 | 0.125 | 0.625 | Up | 0.003 | 0.037 | 0.002 | 0.010 |
| GO:1902580 | 33 | 0.273 | 0.061 | Down | 0.003 | 0.037 | 0.007 | 0.018 |
| GO:1901137 | 55 | 0.145 | 0.327 | Up | 0.003 | 0.037 | 0.001 | 0.006 |
| GO:0009206 | 8 | 0.125 | 0.625 | Up | 0.004 | 0.037 | 0.002 | 0.010 |
| GO:0006378 | 5 | 0.200 | 0.600 | Up | 0.004 | 0.037 | 0.003 | 0.010 |
| GO:0050790 | 27 | 0.259 | 0.370 | Up | 0.004 | 0.037 | 0.001 | 0.006 |
| GO:0006325 | 29 | 0.345 | 0.172 | Down | 0.004 | 0.037 | 0.001 | 0.008 |
| GO:0006281 | 50 | 0.160 | 0.220 | Up | 0.004 | 0.037 | 0.003 | 0.011 |
| GO:0033554 | 55 | 0.200 | 0.200 | Up | 0.004 | 0.037 | 0.002 | 0.009 |
| GO:0009628 | 22 | 0.500 | 0.091 | Down | 0.004 | 0.037 | 0.002 | 0.009 |
| GO:0043603 | 15 | 0.267 | 0.133 | Down | 0.004 | 0.037 | 0.014 | 0.028 |
| GO:0006996 | 110 | 0.264 | 0.145 | Down | 0.004 | 0.037 | 0.002 | 0.009 |
| GO:0034641 | 602 | 0.236 | 0.199 | Down | 0.004 | 0.037 | 0.000 | 0.006 |
| GO:0044260 | 985 | 0.236 | 0.196 | Down | 0.004 | 0.037 | 0.001 | 0.006 |
| GO:0070585 | 14 | 0.500 | 0.071 | Down | 0.004 | 0.037 | 0.004 | 0.013 |
| GO:0007005 | 14 | 0.500 | 0.071 | Down | 0.004 | 0.037 | 0.004 | 0.013 |
| GO:0071806 | 16 | 0.312 | 0.062 | Down | 0.004 | 0.037 | 0.008 | 0.019 |
| GO:0006396 | 207 | 0.295 | 0.242 | Down | 0.004 | 0.037 | 0.000 | 0.005 |
| GO:0009987 | 1474 | 0.224 | 0.190 | Down | 0.004 | 0.037 | 0.001 | 0.006 |
| GO:0072594 | 32 | 0.281 | 0.062 | Down | 0.004 | 0.037 | 0.007 | 0.018 |
| GO:0044238 | 1268 | 0.226 | 0.189 | Down | 0.004 | 0.037 | 0.000 | 0.006 |
| GO:0043414 | 18 | 0.278 | 0.278 | Down | 0.004 | 0.037 | 0.001 | 0.006 |
| GO:0016043 | 183 | 0.273 | 0.148 | Down | 0.004 | 0.037 | 0.001 | 0.008 |
| GO:0016070 | 365 | 0.266 | 0.227 | Down | 0.004 | 0.037 | 0.001 | 0.006 |
| GO:0008380 | 81 | 0.407 | 0.173 | Down | 0.004 | 0.037 | 0.001 | 0.006 |
| GO:0042559 | 6 | 0.333 | 0.333 | Down | 0.004 | 0.037 | 0.001 | 0.008 |
| GO:0006725 | 583 | 0.233 | 0.201 | Down | 0.004 | 0.037 | 0.000 | 0.006 |
| GO:0046483 | 584 | 0.233 | 0.202 | Down | 0.004 | 0.037 | 0.000 | 0.005 |
| GO:0031124 | 5 | 0.200 | 0.600 | Up | 0.004 | 0.037 | 0.003 | 0.011 |
| GO:1901360 | 587 | 0.232 | 0.201 | Down | 0.004 | 0.037 | 0.000 | 0.003 |
| GO:0006807 | 627 | 0.230 | 0.203 | Down | 0.004 | 0.037 | 0.001 | 0.006 |
| GO:0043933 | 107 | 0.290 | 0.140 | Down | 0.005 | 0.037 | 0.001 | 0.006 |
| GO:0010467 | 524 | 0.258 | 0.200 | Down | 0.005 | 0.037 | 0.000 | 0.005 |
| GO:0043170 | 1043 | 0.232 | 0.196 | Down | 0.005 | 0.037 | 0.001 | 0.006 |
| GO:0009266 | 21 | 0.476 | 0.095 | Down | 0.005 | 0.037 | 0.002 | 0.009 |
| GO:0065009 | 27 | 0.259 | 0.370 | Up | 0.005 | 0.037 | 0.001 | 0.006 |
| GO:0046390 | 19 | 0.105 | 0.316 | Up | 0.005 | 0.037 | 0.005 | 0.015 |
| GO:0006139 | 560 | 0.238 | 0.196 | Down | 0.005 | 0.037 | 0.000 | 0.004 |
| GO:0006094 | 5 | 0.800 | 0.000 | Down | 0.005 | 0.037 | 0.005 | 0.015 |
| GO:0042398 | 11 | 0.273 | 0.273 | Down | 0.005 | 0.037 | 0.002 | 0.010 |
| GO:0051276 | 43 | 0.326 | 0.140 | Down | 0.005 | 0.037 | 0.005 | 0.014 |
| GO:0033365 | 33 | 0.273 | 0.091 | Down | 0.005 | 0.037 | 0.007 | 0.017 |
| GO:0072655 | 14 | 0.500 | 0.071 | Down | 0.005 | 0.037 | 0.005 | 0.015 |
| GO:0006626 | 14 | 0.500 | 0.071 | Down | 0.005 | 0.037 | 0.005 | 0.015 |
| GO:0072657 | 11 | 0.273 | 0.091 | Down | 0.005 | 0.037 | 0.005 | 0.015 |
| GO:0090304 | 471 | 0.246 | 0.210 | Down | 0.005 | 0.037 | 0.001 | 0.006 |
| GO:0006974 | 51 | 0.176 | 0.216 | Up | 0.005 | 0.037 | 0.004 | 0.013 |
| GO:0045454 | 29 | 0.345 | 0.207 | Down | 0.005 | 0.037 | 0.000 | 0.004 |
| GO:0002097 | 4 | 0.000 | 0.500 | Up | 0.005 | 0.038 | 0.011 | 0.024 |
| GO:0046364 | 6 | 0.667 | 0.000 | Down | 0.005 | 0.038 | 0.007 | 0.017 |
| GO:0016255 | 4 | 0.000 | 1.000 | Up | 0.005 | 0.038 | 0.006 | 0.017 |
| GO:0019319 | 6 | 0.667 | 0.000 | Down | 0.005 | 0.038 | 0.006 | 0.017 |
| GO:0006605 | 34 | 0.265 | 0.059 | Down | 0.005 | 0.038 | 0.009 | 0.021 |
| GO:0031338 | 14 | 0.000 | 0.357 | Up | 0.005 | 0.038 | 0.003 | 0.012 |
| GO:0071704 | 1299 | 0.221 | 0.193 | Down | 0.006 | 0.039 | 0.001 | 0.006 |
| GO:0051188 | 30 | 0.067 | 0.333 | Up | 0.006 | 0.039 | 0.002 | 0.010 |
| GO:0006520 | 75 | 0.280 | 0.200 | Down | 0.006 | 0.039 | 0.001 | 0.008 |
| GO:0090150 | 11 | 0.273 | 0.091 | Down | 0.006 | 0.039 | 0.006 | 0.016 |
| GO:0009408 | 20 | 0.450 | 0.100 | Down | 0.006 | 0.039 | 0.002 | 0.009 |
| GO:0019222 | 152 | 0.243 | 0.184 | Down | 0.006 | 0.039 | 0.003 | 0.011 |
| GO:0006813 | 4 | 0.000 | 0.500 | Up | 0.006 | 0.039 | 0.019 | 0.036 |
| GO:0008213 | 8 | 0.375 | 0.250 | Down | 0.006 | 0.039 | 0.001 | 0.008 |
| GO:0016071 | 100 | 0.310 | 0.240 | Down | 0.006 | 0.039 | 0.001 | 0.006 |
| GO:0035966 | 12 | 0.417 | 0.083 | Down | 0.006 | 0.039 | 0.003 | 0.011 |
| GO:0008152 | 1383 | 0.221 | 0.195 | Down | 0.006 | 0.039 | 0.001 | 0.006 |
| GO:0006479 | 8 | 0.375 | 0.250 | Down | 0.006 | 0.039 | 0.002 | 0.009 |
| GO:0033124 | 18 | 0.222 | 0.333 | Up | 0.006 | 0.039 | 0.001 | 0.006 |
| GO:0032012 | 3 | 0.333 | 0.667 | Up | 0.006 | 0.039 | 0.001 | 0.007 |
| GO:0006164 | 19 | 0.105 | 0.316 | Up | 0.006 | 0.039 | 0.002 | 0.009 |
| GO:0044237 | 1238 | 0.226 | 0.193 | Down | 0.006 | 0.039 | 0.001 | 0.006 |
| GO:0010608 | 25 | 0.360 | 0.080 | Down | 0.006 | 0.039 | 0.005 | 0.014 |
| GO:0032312 | 2 | 0.000 | 1.000 | Up | 0.006 | 0.039 | 0.006 | 0.017 |
| GO:0032259 | 26 | 0.269 | 0.231 | Down | 0.006 | 0.039 | 0.000 | 0.003 |
| GO:0009145 | 9 | 0.222 | 0.556 | Up | 0.006 | 0.040 | 0.000 | 0.005 |
| GO:0043087 | 18 | 0.222 | 0.333 | Up | 0.007 | 0.040 | 0.001 | 0.007 |
| GO:0051051 | 3 | 0.000 | 1.000 | Up | 0.007 | 0.040 | 0.007 | 0.018 |
| GO:0006271 | 5 | 0.000 | 0.600 | Up | 0.007 | 0.040 | 0.017 | 0.033 |
| GO:0042493 | 51 | 0.235 | 0.078 | Down | 0.007 | 0.040 | 0.002 | 0.010 |
| GO:0006265 | 3 | 0.667 | 0.333 | Down | 0.007 | 0.041 | 0.002 | 0.008 |
| GO:0000154 | 5 | 0.600 | 0.000 | Down | 0.007 | 0.042 | 0.004 | 0.014 |
| GO:0019752 | 129 | 0.279 | 0.178 | Down | 0.007 | 0.042 | 0.002 | 0.010 |
| GO:0009894 | 22 | 0.364 | 0.273 | Down | 0.007 | 0.042 | 0.001 | 0.006 |
| GO:1901564 | 179 | 0.246 | 0.201 | Down | 0.007 | 0.042 | 0.001 | 0.006 |
| GO:0019538 | 628 | 0.231 | 0.182 | Down | 0.007 | 0.042 | 0.001 | 0.006 |
| GO:0030029 | 10 | 0.300 | 0.200 | Down | 0.007 | 0.043 | 0.004 | 0.014 |
| GO:0006986 | 12 | 0.417 | 0.083 | Down | 0.008 | 0.043 | 0.003 | 0.012 |
| GO:0000377 | 59 | 0.407 | 0.186 | Down | 0.008 | 0.043 | 0.001 | 0.006 |
| GO:0042451 | 17 | 0.176 | 0.353 | Up | 0.008 | 0.043 | 0.001 | 0.007 |
| GO:0010033 | 13 | 0.385 | 0.077 | Down | 0.008 | 0.043 | 0.003 | 0.012 |
| GO:0043436 | 130 | 0.277 | 0.177 | Down | 0.008 | 0.043 | 0.002 | 0.009 |
| GO:0044724 | 24 | 0.583 | 0.042 | Down | 0.008 | 0.043 | 0.008 | 0.019 |
| GO:0000375 | 64 | 0.422 | 0.172 | Down | 0.008 | 0.043 | 0.001 | 0.007 |
| GO:0000398 | 59 | 0.407 | 0.186 | Down | 0.008 | 0.044 | 0.001 | 0.006 |
| GO:0006397 | 93 | 0.323 | 0.258 | Down | 0.008 | 0.044 | 0.001 | 0.006 |
| GO:0034968 | 4 | 0.500 | 0.000 | Down | 0.008 | 0.044 | 0.006 | 0.017 |
| GO:0080090 | 141 | 0.234 | 0.184 | Down | 0.008 | 0.044 | 0.002 | 0.010 |
| GO:0000079 | 3 | 0.000 | 1.000 | Up | 0.008 | 0.044 | 0.009 | 0.020 |
| GO:0046129 | 17 | 0.176 | 0.353 | Up | 0.008 | 0.044 | 0.001 | 0.007 |
| GO:0006096 | 17 | 0.647 | 0.059 | Down | 0.008 | 0.044 | 0.008 | 0.019 |
| GO:0009247 | 12 | 0.083 | 0.583 | Up | 0.009 | 0.045 | 0.010 | 0.023 |
| GO:0051336 | 21 | 0.286 | 0.333 | Up | 0.009 | 0.045 | 0.000 | 0.003 |
| GO:0030036 | 8 | 0.250 | 0.250 | Down | 0.009 | 0.045 | 0.005 | 0.015 |
| GO:0006338 | 4 | 0.500 | 0.000 | Down | 0.009 | 0.045 | 0.013 | 0.028 |
| GO:0006140 | 19 | 0.263 | 0.316 | Up | 0.009 | 0.045 | 0.001 | 0.006 |
| GO:0016052 | 24 | 0.583 | 0.042 | Down | 0.009 | 0.045 | 0.009 | 0.022 |
| GO:0000910 | 4 | 0.000 | 0.500 | Up | 0.009 | 0.045 | 0.019 | 0.036 |
| GO:0006081 | 6 | 0.167 | 0.333 | Up | 0.009 | 0.045 | 0.006 | 0.017 |
| GO:0016051 | 12 | 0.500 | 0.000 | Down | 0.009 | 0.045 | 0.008 | 0.019 |
| GO:0030811 | 19 | 0.263 | 0.316 | Up | 0.009 | 0.045 | 0.001 | 0.007 |
| GO:0006790 | 20 | 0.100 | 0.300 | Up | 0.009 | 0.045 | 0.009 | 0.022 |
| GO:0033121 | 19 | 0.263 | 0.316 | Up | 0.009 | 0.045 | 0.001 | 0.006 |
| GO:0034660 | 124 | 0.266 | 0.234 | Down | 0.009 | 0.045 | 0.001 | 0.006 |
| GO:0043412 | 249 | 0.157 | 0.225 | Up | 0.009 | 0.045 | 0.001 | 0.007 |
| GO:0006475 | 4 | 0.000 | 0.750 | Up | 0.009 | 0.045 | 0.033 | 0.053 |
| GO:0009118 | 19 | 0.263 | 0.316 | Up | 0.009 | 0.045 | 0.000 | 0.006 |
| GO:0022616 | 5 | 0.000 | 0.600 | Up | 0.009 | 0.045 | 0.021 | 0.039 |
| GO:0051651 | 2 | 0.000 | 1.000 | Up | 0.010 | 0.045 | 0.010 | 0.022 |
| GO:0006082 | 130 | 0.277 | 0.177 | Down | 0.010 | 0.045 | 0.003 | 0.011 |
| GO:1900542 | 19 | 0.263 | 0.316 | Up | 0.010 | 0.045 | 0.001 | 0.006 |
| GO:1901607 | 11 | 0.182 | 0.091 | Down | 0.010 | 0.045 | 0.021 | 0.038 |
| GO:0018393 | 4 | 0.000 | 0.750 | Up | 0.010 | 0.045 | 0.033 | 0.053 |
| GO:0009452 | 6 | 0.333 | 0.167 | Down | 0.010 | 0.045 | 0.002 | 0.010 |
| GO:0022613 | 98 | 0.327 | 0.143 | Down | 0.010 | 0.045 | 0.002 | 0.010 |
| GO:0071900 | 3 | 0.000 | 1.000 | Up | 0.010 | 0.045 | 0.010 | 0.023 |
| GO:0006379 | 4 | 0.250 | 0.750 | Up | 0.010 | 0.045 | 0.007 | 0.018 |
| GO:0046467 | 13 | 0.077 | 0.615 | Up | 0.010 | 0.045 | 0.010 | 0.023 |
| GO:0006465 | 7 | 0.429 | 0.000 | Down | 0.010 | 0.045 | 0.024 | 0.043 |
| GO:0009108 | 24 | 0.083 | 0.292 | Up | 0.010 | 0.045 | 0.002 | 0.009 |
| GO:0016573 | 4 | 0.000 | 0.750 | Up | 0.010 | 0.046 | 0.033 | 0.053 |
| GO:0044743 | 6 | 0.667 | 0.000 | Down | 0.010 | 0.046 | 0.009 | 0.020 |
| GO:0042558 | 7 | 0.286 | 0.429 | Down | 0.010 | 0.046 | 0.001 | 0.008 |
| GO:0010468 | 116 | 0.224 | 0.147 | Down | 0.010 | 0.046 | 0.006 | 0.016 |
| GO:0048523 | 10 | 0.300 | 0.200 | Down | 0.010 | 0.046 | 0.007 | 0.018 |
| GO:0006754 | 7 | 0.143 | 0.571 | Up | 0.010 | 0.046 | 0.007 | 0.018 |
| GO:0034622 | 64 | 0.328 | 0.141 | Down | 0.010 | 0.046 | 0.003 | 0.011 |
| GO:0031329 | 19 | 0.263 | 0.316 | Up | 0.010 | 0.046 | 0.001 | 0.006 |
| GO:0006410 | 5 | 0.000 | 0.600 | Up | 0.011 | 0.046 | 0.021 | 0.038 |
| GO:0044712 | 59 | 0.339 | 0.136 | Down | 0.011 | 0.046 | 0.004 | 0.013 |
| GO:0006399 | 78 | 0.231 | 0.269 | Up | 0.011 | 0.046 | 0.002 | 0.008 |
| GO:0032507 | 2 | 0.000 | 1.000 | Up | 0.011 | 0.046 | 0.011 | 0.024 |
| GO:0036260 | 6 | 0.333 | 0.167 | Down | 0.011 | 0.046 | 0.002 | 0.009 |
| GO:0008616 | 4 | 0.500 | 0.250 | Down | 0.011 | 0.046 | 0.005 | 0.014 |
| GO:0046116 | 4 | 0.500 | 0.250 | Down | 0.011 | 0.046 | 0.006 | 0.016 |
| GO:0033043 | 19 | 0.053 | 0.316 | Up | 0.011 | 0.046 | 0.004 | 0.013 |
| GO:0060255 | 128 | 0.234 | 0.164 | Down | 0.011 | 0.046 | 0.004 | 0.013 |
| GO:0006090 | 24 | 0.458 | 0.167 | Down | 0.011 | 0.047 | 0.004 | 0.014 |
| GO:0018394 | 4 | 0.000 | 0.750 | Up | 0.011 | 0.047 | 0.033 | 0.053 |
| GO:0006006 | 12 | 0.583 | 0.000 | Down | 0.011 | 0.047 | 0.013 | 0.027 |
| GO:0006289 | 11 | 0.182 | 0.364 | Up | 0.011 | 0.047 | 0.001 | 0.006 |
| GO:0044267 | 562 | 0.237 | 0.181 | Down | 0.011 | 0.047 | 0.002 | 0.008 |
| GO:0010629 | 6 | 0.500 | 0.167 | Down | 0.011 | 0.047 | 0.003 | 0.011 |
| GO:0042158 | 18 | 0.000 | 0.556 | Up | 0.012 | 0.048 | 0.013 | 0.028 |
| GO:0043241 | 6 | 0.000 | 0.500 | Up | 0.012 | 0.048 | 0.062 | 0.083 |
| GO:0044271 | 158 | 0.196 | 0.215 | Up | 0.012 | 0.049 | 0.000 | 0.005 |
| GO:0042176 | 3 | 1.000 | 0.000 | Down | 0.012 | 0.049 | 0.012 | 0.026 |
| GO:0065003 | 74 | 0.297 | 0.135 | Down | 0.012 | 0.049 | 0.002 | 0.010 |
| GO:0016072 | 48 | 0.312 | 0.188 | Down | 0.012 | 0.049 | 0.002 | 0.009 |
| GO:0006497 | 18 | 0.000 | 0.556 | Up | 0.012 | 0.049 | 0.013 | 0.028 |
| GO:0042157 | 18 | 0.000 | 0.556 | Up | 0.012 | 0.049 | 0.013 | 0.028 |
| GO:0045017 | 17 | 0.059 | 0.471 | Up | 0.012 | 0.049 | 0.007 | 0.018 |
| GO:0043543 | 15 | 0.000 | 0.467 | Up | 0.012 | 0.049 | 0.034 | 0.053 |
| GO:0045859 | 4 | 0.000 | 0.750 | Up | 0.013 | 0.049 | 0.020 | 0.037 |
| GO:0051186 | 45 | 0.156 | 0.267 | Up | 0.013 | 0.049 | 0.001 | 0.006 |
| GO:0043549 | 4 | 0.000 | 0.750 | Up | 0.013 | 0.049 | 0.019 | 0.036 |
| GO:0022607 | 83 | 0.289 | 0.145 | Down | 0.013 | 0.049 | 0.002 | 0.009 |
| GO:0006413 | 48 | 0.208 | 0.167 | Down | 0.013 | 0.049 | 0.007 | 0.018 |
| GO:0031323 | 139 | 0.216 | 0.194 | Down | 0.013 | 0.049 | 0.002 | 0.010 |
| GO:0006664 | 13 | 0.077 | 0.538 | Up | 0.013 | 0.049 | 0.015 | 0.030 |
| GO:0035383 | 7 | 0.000 | 0.429 | Up | 0.013 | 0.049 | 0.017 | 0.032 |
| GO:0009892 | 8 | 0.375 | 0.250 | Down | 0.013 | 0.049 | 0.001 | 0.008 |
| GO:0043648 | 10 | 0.300 | 0.000 | Down | 0.013 | 0.049 | 0.038 | 0.057 |
| GO:0006259 | 120 | 0.175 | 0.192 | Up | 0.013 | 0.050 | 0.001 | 0.007 |
| GO:0090305 | 10 | 0.200 | 0.500 | Up | 0.013 | 0.050 | 0.004 | 0.013 |
| GO:0007275 | 6 | 0.000 | 0.333 | Up | 0.013 | 0.050 | 0.016 | 0.032 |
| GO:0007018 | 19 | 0.263 | 0.211 | Down | 0.013 | 0.050 | 0.001 | 0.006 |
| GO:0015985 | 7 | 0.143 | 0.571 | Up | 0.013 | 0.050 | 0.009 | 0.021 |
| GO:0006364 | 48 | 0.312 | 0.188 | Down | 0.013 | 0.050 | 0.002 | 0.009 |
| GO:0015986 | 7 | 0.143 | 0.571 | Up | 0.014 | 0.050 | 0.009 | 0.021 |
| GO:0065002 | 11 | 0.364 | 0.000 | Down | 0.014 | 0.050 | 0.020 | 0.037 |
| GO:0019725 | 42 | 0.262 | 0.238 | Up | 0.014 | 0.051 | 0.000 | 0.006 |
| GO:0006417 | 22 | 0.318 | 0.091 | Down | 0.014 | 0.052 | 0.008 | 0.020 |
| GO:0044092 | 3 | 0.667 | 0.333 | Down | 0.014 | 0.052 | 0.001 | 0.007 |
| GO:0043086 | 3 | 0.667 | 0.333 | Down | 0.014 | 0.052 | 0.001 | 0.007 |
| GO:0071826 | 31 | 0.323 | 0.097 | Down | 0.014 | 0.052 | 0.014 | 0.028 |
| GO:0044707 | 7 | 0.000 | 0.286 | Up | 0.014 | 0.052 | 0.026 | 0.045 |
| GO:0006875 | 4 | 0.250 | 0.750 | Up | 0.014 | 0.052 | 0.002 | 0.009 |
| GO:0019318 | 14 | 0.500 | 0.000 | Down | 0.015 | 0.052 | 0.019 | 0.036 |
| GO:0032318 | 15 | 0.200 | 0.333 | Up | 0.015 | 0.052 | 0.002 | 0.010 |
| GO:0051338 | 4 | 0.000 | 0.750 | Up | 0.015 | 0.053 | 0.020 | 0.037 |
| GO:0090501 | 4 | 0.250 | 0.500 | Down | 0.015 | 0.053 | 0.002 | 0.008 |
| GO:0006839 | 18 | 0.389 | 0.056 | Down | 0.015 | 0.053 | 0.015 | 0.030 |
| GO:0006643 | 15 | 0.067 | 0.600 | Up | 0.015 | 0.053 | 0.014 | 0.029 |
| GO:0051246 | 31 | 0.355 | 0.194 | Down | 0.015 | 0.053 | 0.004 | 0.014 |
| GO:1902531 | 17 | 0.294 | 0.294 | Down | 0.015 | 0.053 | 0.001 | 0.006 |
| GO:0044763 | 585 | 0.200 | 0.191 | Up | 0.015 | 0.054 | 0.000 | 0.006 |
| GO:0042455 | 22 | 0.227 | 0.318 | Up | 0.016 | 0.054 | 0.000 | 0.005 |
| GO:0006066 | 7 | 0.286 | 0.000 | Down | 0.016 | 0.054 | 0.045 | 0.064 |
| GO:0046474 | 16 | 0.062 | 0.500 | Up | 0.016 | 0.054 | 0.008 | 0.020 |
| GO:0010605 | 7 | 0.429 | 0.286 | Down | 0.016 | 0.054 | 0.001 | 0.007 |
| GO:1901605 | 24 | 0.167 | 0.167 | Down | 0.016 | 0.054 | 0.006 | 0.016 |
| GO:0006637 | 7 | 0.000 | 0.429 | Up | 0.016 | 0.054 | 0.018 | 0.035 |
| GO:0034654 | 128 | 0.211 | 0.188 | Down | 0.016 | 0.054 | 0.001 | 0.007 |
| GO:0018130 | 152 | 0.204 | 0.204 | Down | 0.016 | 0.054 | 0.001 | 0.006 |
| GO:0051716 | 109 | 0.174 | 0.156 | Up | 0.016 | 0.054 | 0.002 | 0.010 |
| GO:0006732 | 37 | 0.189 | 0.243 | Up | 0.016 | 0.054 | 0.000 | 0.006 |
| GO:0006812 | 42 | 0.214 | 0.262 | Up | 0.016 | 0.054 | 0.001 | 0.006 |
| GO:0007049 | 36 | 0.083 | 0.167 | Up | 0.016 | 0.054 | 0.020 | 0.037 |
| GO:0006506 | 9 | 0.000 | 0.667 | Up | 0.016 | 0.054 | 0.016 | 0.032 |
| GO:0005996 | 14 | 0.500 | 0.000 | Down | 0.017 | 0.054 | 0.019 | 0.036 |
| GO:0044272 | 14 | 0.071 | 0.357 | Up | 0.017 | 0.054 | 0.022 | 0.039 |
| GO:0046578 | 17 | 0.294 | 0.294 | Down | 0.017 | 0.054 | 0.000 | 0.004 |
| GO:0044767 | 11 | 0.000 | 0.273 | Up | 0.017 | 0.054 | 0.019 | 0.036 |
| GO:0044723 | 42 | 0.429 | 0.071 | Down | 0.017 | 0.054 | 0.008 | 0.019 |
| GO:0009142 | 10 | 0.200 | 0.500 | Up | 0.017 | 0.054 | 0.002 | 0.010 |
| GO:0032501 | 8 | 0.000 | 0.250 | Up | 0.017 | 0.054 | 0.040 | 0.060 |
| GO:0048518 | 11 | 0.364 | 0.091 | Down | 0.017 | 0.054 | 0.010 | 0.023 |
| GO:0009163 | 22 | 0.227 | 0.318 | Up | 0.017 | 0.054 | 0.000 | 0.005 |
| GO:0070647 | 29 | 0.310 | 0.172 | Down | 0.017 | 0.054 | 0.002 | 0.009 |
| GO:0071976 | 4 | 0.000 | 0.250 | Up | 0.017 | 0.055 | 0.057 | 0.078 |
| GO:0006897 | 7 | 0.286 | 0.143 | Down | 0.017 | 0.055 | 0.004 | 0.012 |
| GO:0009451 | 43 | 0.140 | 0.233 | Up | 0.017 | 0.055 | 0.001 | 0.006 |
| GO:0055065 | 4 | 0.250 | 0.750 | Up | 0.017 | 0.055 | 0.002 | 0.009 |
| GO:0009889 | 111 | 0.207 | 0.153 | Down | 0.017 | 0.055 | 0.005 | 0.015 |
| GO:0044281 | 231 | 0.242 | 0.169 | Down | 0.017 | 0.055 | 0.002 | 0.009 |
| GO:0009058 | 529 | 0.189 | 0.208 | Up | 0.018 | 0.055 | 0.001 | 0.007 |
| GO:0051056 | 17 | 0.294 | 0.294 | Down | 0.018 | 0.055 | 0.001 | 0.006 |
| GO:0046148 | 6 | 0.000 | 0.500 | Up | 0.018 | 0.056 | 0.050 | 0.069 |
| GO:0044249 | 516 | 0.186 | 0.205 | Up | 0.018 | 0.056 | 0.001 | 0.008 |
| GO:0031326 | 111 | 0.207 | 0.153 | Down | 0.018 | 0.056 | 0.006 | 0.017 |
| GO:1901362 | 155 | 0.200 | 0.200 | Down | 0.018 | 0.056 | 0.000 | 0.005 |
| GO:0006779 | 6 | 0.000 | 0.500 | Up | 0.018 | 0.056 | 0.047 | 0.066 |
| GO:0016042 | 5 | 0.200 | 0.400 | Up | 0.019 | 0.056 | 0.001 | 0.006 |
| GO:0032879 | 27 | 0.111 | 0.333 | Up | 0.019 | 0.056 | 0.002 | 0.009 |
| GO:0030001 | 16 | 0.188 | 0.312 | Up | 0.019 | 0.056 | 0.004 | 0.014 |
| GO:0045892 | 4 | 0.500 | 0.000 | Down | 0.019 | 0.056 | 0.029 | 0.048 |
| GO:0005975 | 53 | 0.377 | 0.094 | Down | 0.019 | 0.056 | 0.006 | 0.017 |
| GO:0072522 | 22 | 0.182 | 0.273 | Up | 0.019 | 0.056 | 0.002 | 0.009 |
| GO:0000350 | 3 | 0.667 | 0.333 | Down | 0.019 | 0.057 | 0.008 | 0.019 |
| GO:0006351 | 81 | 0.210 | 0.185 | Down | 0.019 | 0.057 | 0.002 | 0.009 |
| GO:2000112 | 110 | 0.209 | 0.155 | Down | 0.019 | 0.057 | 0.007 | 0.018 |
| GO:0051172 | 4 | 0.500 | 0.000 | Down | 0.019 | 0.057 | 0.027 | 0.047 |
| GO:0051049 | 27 | 0.111 | 0.333 | Up | 0.019 | 0.057 | 0.001 | 0.008 |
| GO:0032502 | 12 | 0.000 | 0.250 | Up | 0.019 | 0.057 | 0.024 | 0.043 |
| GO:0051128 | 22 | 0.091 | 0.273 | Up | 0.020 | 0.057 | 0.002 | 0.009 |
| GO:0019438 | 148 | 0.203 | 0.203 | Up | 0.020 | 0.057 | 0.001 | 0.006 |
| GO:0044802 | 14 | 0.214 | 0.143 | Down | 0.020 | 0.058 | 0.005 | 0.015 |
| GO:0033014 | 6 | 0.000 | 0.500 | Up | 0.020 | 0.058 | 0.051 | 0.071 |
| GO:0009056 | 171 | 0.304 | 0.140 | Down | 0.020 | 0.058 | 0.003 | 0.011 |
| GO:0006783 | 6 | 0.000 | 0.500 | Up | 0.020 | 0.058 | 0.048 | 0.068 |
| GO:0045934 | 4 | 0.500 | 0.000 | Down | 0.020 | 0.058 | 0.028 | 0.047 |
| GO:0010556 | 110 | 0.209 | 0.155 | Down | 0.020 | 0.058 | 0.005 | 0.015 |
| GO:1901659 | 23 | 0.217 | 0.304 | Up | 0.020 | 0.058 | 0.000 | 0.004 |
| GO:2000113 | 4 | 0.500 | 0.000 | Down | 0.020 | 0.058 | 0.028 | 0.048 |
| GO:0001510 | 9 | 0.222 | 0.333 | Up | 0.020 | 0.058 | 0.000 | 0.003 |
| GO:0051253 | 4 | 0.500 | 0.000 | Down | 0.021 | 0.059 | 0.026 | 0.045 |
| GO:0032784 | 3 | 0.667 | 0.000 | Down | 0.021 | 0.059 | 0.023 | 0.042 |
| GO:1902679 | 4 | 0.500 | 0.000 | Down | 0.021 | 0.059 | 0.028 | 0.048 |
| GO:0048583 | 27 | 0.259 | 0.222 | Down | 0.021 | 0.059 | 0.000 | 0.006 |
| GO:0045185 | 3 | 0.000 | 0.667 | Up | 0.021 | 0.059 | 0.016 | 0.032 |
| GO:0061024 | 17 | 0.235 | 0.118 | Down | 0.021 | 0.059 | 0.010 | 0.023 |
| GO:0042254 | 80 | 0.288 | 0.150 | Down | 0.021 | 0.059 | 0.004 | 0.013 |
| GO:1901576 | 518 | 0.189 | 0.203 | Up | 0.021 | 0.059 | 0.001 | 0.007 |
| GO:0006820 | 41 | 0.146 | 0.098 | Down | 0.021 | 0.060 | 0.029 | 0.049 |
| GO:0006904 | 4 | 0.500 | 0.250 | Down | 0.022 | 0.061 | 0.000 | 0.001 |
| GO:0009132 | 5 | 0.200 | 0.400 | Up | 0.022 | 0.061 | 0.001 | 0.006 |
| GO:0010558 | 4 | 0.500 | 0.000 | Down | 0.022 | 0.062 | 0.029 | 0.048 |
| GO:0022618 | 29 | 0.345 | 0.103 | Down | 0.023 | 0.062 | 0.014 | 0.028 |
| GO:1901575 | 165 | 0.303 | 0.145 | Down | 0.023 | 0.062 | 0.003 | 0.012 |
| GO:0007015 | 4 | 0.250 | 0.000 | Down | 0.023 | 0.063 | 0.030 | 0.049 |
| GO:0006661 | 10 | 0.000 | 0.600 | Up | 0.023 | 0.063 | 0.023 | 0.041 |
| GO:0006086 | 4 | 0.000 | 0.500 | Up | 0.023 | 0.063 | 0.033 | 0.053 |
| GO:0048278 | 4 | 0.500 | 0.250 | Down | 0.023 | 0.063 | 0.000 | 0.003 |
| GO:0031163 | 4 | 0.250 | 0.500 | Up | 0.023 | 0.063 | 0.004 | 0.013 |
| GO:0022406 | 4 | 0.500 | 0.250 | Down | 0.024 | 0.064 | 0.000 | 0.003 |
| GO:0006464 | 206 | 0.160 | 0.218 | Up | 0.024 | 0.064 | 0.001 | 0.008 |
| GO:0051235 | 3 | 0.000 | 0.667 | Up | 0.024 | 0.064 | 0.016 | 0.031 |
| GO:0016226 | 4 | 0.250 | 0.500 | Up | 0.024 | 0.064 | 0.004 | 0.012 |
| GO:0035384 | 4 | 0.000 | 0.500 | Up | 0.024 | 0.064 | 0.032 | 0.053 |
| GO:0009890 | 5 | 0.400 | 0.000 | Down | 0.024 | 0.064 | 0.032 | 0.052 |
| GO:0006508 | 138 | 0.268 | 0.181 | Down | 0.025 | 0.066 | 0.001 | 0.008 |
| GO:0035890 | 12 | 0.083 | 0.250 | Up | 0.025 | 0.066 | 0.058 | 0.079 |
| GO:0036211 | 206 | 0.160 | 0.218 | Up | 0.025 | 0.066 | 0.001 | 0.008 |
| GO:0044106 | 8 | 0.250 | 0.125 | Down | 0.025 | 0.066 | 0.013 | 0.027 |
| GO:0006357 | 10 | 0.300 | 0.100 | Down | 0.026 | 0.067 | 0.016 | 0.032 |
| GO:0006629 | 86 | 0.140 | 0.256 | Up | 0.026 | 0.067 | 0.004 | 0.014 |
| GO:0006869 | 9 | 0.222 | 0.222 | Down | 0.026 | 0.067 | 0.010 | 0.023 |
| GO:0032774 | 84 | 0.202 | 0.190 | Down | 0.026 | 0.068 | 0.001 | 0.008 |
| GO:0031327 | 5 | 0.400 | 0.000 | Down | 0.026 | 0.068 | 0.035 | 0.054 |
| GO:0019320 | 9 | 0.556 | 0.000 | Down | 0.026 | 0.068 | 0.027 | 0.047 |
| GO:0043248 | 8 | 0.625 | 0.125 | Down | 0.026 | 0.068 | 0.019 | 0.036 |
| GO:0006505 | 10 | 0.000 | 0.600 | Up | 0.026 | 0.068 | 0.025 | 0.045 |
| GO:0006085 | 4 | 0.000 | 0.500 | Up | 0.026 | 0.068 | 0.036 | 0.055 |
| GO:0018193 | 25 | 0.280 | 0.320 | Up | 0.026 | 0.068 | 0.000 | 0.004 |
| GO:0006098 | 9 | 0.556 | 0.000 | Down | 0.026 | 0.068 | 0.028 | 0.047 |
| GO:0009438 | 2 | 0.000 | 0.500 | Up | 0.027 | 0.068 | 0.005 | 0.015 |
| GO:0032268 | 27 | 0.259 | 0.222 | Down | 0.027 | 0.068 | 0.005 | 0.014 |
| GO:0042592 | 47 | 0.255 | 0.234 | Up | 0.027 | 0.068 | 0.001 | 0.007 |
| GO:0010876 | 9 | 0.222 | 0.222 | Down | 0.027 | 0.068 | 0.008 | 0.019 |
| GO:0070682 | 6 | 0.833 | 0.000 | Down | 0.027 | 0.068 | 0.027 | 0.047 |
| GO:0050657 | 7 | 0.286 | 0.143 | Down | 0.027 | 0.069 | 0.034 | 0.054 |
| GO:0034470 | 83 | 0.229 | 0.253 | Down | 0.028 | 0.069 | 0.002 | 0.009 |
| GO:0046365 | 9 | 0.556 | 0.000 | Down | 0.028 | 0.069 | 0.026 | 0.045 |
| GO:0044710 | 420 | 0.210 | 0.205 | Down | 0.028 | 0.069 | 0.001 | 0.007 |
| GO:0006165 | 2 | 0.500 | 0.500 | Up | 0.028 | 0.070 | 0.002 | 0.009 |
| GO:0050658 | 7 | 0.286 | 0.143 | Down | 0.028 | 0.070 | 0.033 | 0.053 |
| GO:0006740 | 9 | 0.556 | 0.000 | Down | 0.028 | 0.070 | 0.027 | 0.047 |
| GO:0046939 | 2 | 0.500 | 0.500 | Up | 0.029 | 0.070 | 0.002 | 0.010 |
| GO:0010564 | 17 | 0.118 | 0.235 | Up | 0.029 | 0.070 | 0.036 | 0.056 |
| GO:0051236 | 7 | 0.286 | 0.143 | Down | 0.029 | 0.070 | 0.035 | 0.054 |
| GO:0009308 | 8 | 0.250 | 0.125 | Down | 0.029 | 0.070 | 0.014 | 0.029 |
| GO:0051726 | 29 | 0.207 | 0.241 | Up | 0.029 | 0.070 | 0.006 | 0.016 |
| GO:0006739 | 9 | 0.556 | 0.000 | Down | 0.029 | 0.070 | 0.029 | 0.049 |
| GO:0006576 | 8 | 0.250 | 0.125 | Down | 0.029 | 0.070 | 0.014 | 0.028 |
| GO:0044711 | 147 | 0.184 | 0.231 | Up | 0.029 | 0.071 | 0.001 | 0.006 |
| GO:0032271 | 5 | 0.200 | 0.200 | Down | 0.029 | 0.071 | 0.068 | 0.090 |
| GO:0042777 | 1 | 0.000 | 1.000 | Up | 0.030 | 0.071 | 0.030 | 0.049 |
| GO:0006007 | 9 | 0.556 | 0.000 | Down | 0.030 | 0.071 | 0.029 | 0.048 |
| GO:0019362 | 10 | 0.500 | 0.000 | Down | 0.030 | 0.071 | 0.038 | 0.057 |
| GO:0006403 | 7 | 0.286 | 0.143 | Down | 0.030 | 0.071 | 0.039 | 0.058 |
| GO:0046496 | 10 | 0.500 | 0.000 | Down | 0.030 | 0.071 | 0.040 | 0.060 |
| GO:0044087 | 5 | 0.200 | 0.200 | Down | 0.030 | 0.071 | 0.067 | 0.089 |
| GO:0032956 | 5 | 0.200 | 0.200 | Down | 0.030 | 0.072 | 0.068 | 0.089 |
| GO:0008064 | 5 | 0.200 | 0.200 | Down | 0.030 | 0.072 | 0.064 | 0.085 |
| GO:0030832 | 5 | 0.200 | 0.200 | Down | 0.030 | 0.072 | 0.067 | 0.089 |
| GO:0006511 | 71 | 0.338 | 0.155 | Down | 0.030 | 0.072 | 0.004 | 0.013 |
| GO:0090407 | 64 | 0.172 | 0.250 | Up | 0.031 | 0.072 | 0.002 | 0.009 |
| GO:0071616 | 4 | 0.000 | 0.500 | Up | 0.031 | 0.072 | 0.040 | 0.060 |
| GO:0015718 | 7 | 0.286 | 0.143 | Down | 0.031 | 0.074 | 0.009 | 0.022 |
| GO:0006414 | 20 | 0.350 | 0.100 | Down | 0.032 | 0.074 | 0.015 | 0.030 |
| GO:0033036 | 161 | 0.193 | 0.130 | Down | 0.032 | 0.074 | 0.005 | 0.015 |
| GO:1901566 | 80 | 0.175 | 0.250 | Up | 0.032 | 0.074 | 0.000 | 0.005 |
| GO:0030833 | 5 | 0.200 | 0.200 | Down | 0.032 | 0.074 | 0.068 | 0.090 |
| GO:0043254 | 5 | 0.200 | 0.200 | Down | 0.032 | 0.074 | 0.069 | 0.090 |
| GO:0016482 | 66 | 0.227 | 0.091 | Down | 0.032 | 0.075 | 0.013 | 0.028 |
| GO:0006979 | 10 | 0.400 | 0.100 | Down | 0.033 | 0.075 | 0.027 | 0.047 |
| GO:0032970 | 5 | 0.200 | 0.200 | Down | 0.033 | 0.075 | 0.070 | 0.091 |
| GO:0007010 | 21 | 0.143 | 0.286 | Up | 0.033 | 0.075 | 0.005 | 0.015 |
| GO:0051493 | 5 | 0.200 | 0.200 | Down | 0.033 | 0.075 | 0.070 | 0.091 |
| GO:0032535 | 5 | 0.200 | 0.200 | Down | 0.033 | 0.075 | 0.074 | 0.095 |
| GO:0008654 | 25 | 0.160 | 0.360 | Up | 0.033 | 0.075 | 0.005 | 0.015 |
| GO:0051301 | 23 | 0.043 | 0.261 | Up | 0.033 | 0.076 | 0.024 | 0.043 |
| GO:0018208 | 10 | 0.400 | 0.100 | Down | 0.033 | 0.076 | 0.006 | 0.016 |
| GO:0000413 | 10 | 0.400 | 0.100 | Down | 0.034 | 0.076 | 0.005 | 0.015 |
| GO:0006890 | 6 | 0.000 | 0.333 | Up | 0.034 | 0.076 | 0.041 | 0.060 |
| GO:0006928 | 33 | 0.212 | 0.212 | Down | 0.034 | 0.076 | 0.002 | 0.010 |
| GO:0006644 | 35 | 0.200 | 0.314 | Up | 0.034 | 0.076 | 0.002 | 0.010 |
| GO:0009060 | 17 | 0.118 | 0.294 | Up | 0.034 | 0.076 | 0.020 | 0.037 |
| GO:0008535 | 1 | 0.000 | 1.000 | Up | 0.034 | 0.077 | 0.034 | 0.054 |
| GO:0035891 | 11 | 0.091 | 0.273 | Up | 0.034 | 0.077 | 0.066 | 0.088 |
| GO:0008610 | 53 | 0.132 | 0.283 | Up | 0.035 | 0.077 | 0.012 | 0.026 |
| GO:0090066 | 5 | 0.200 | 0.200 | Down | 0.035 | 0.077 | 0.070 | 0.091 |
| GO:0019219 | 110 | 0.200 | 0.191 | Down | 0.035 | 0.077 | 0.003 | 0.011 |
| GO:0051171 | 110 | 0.200 | 0.191 | Down | 0.035 | 0.078 | 0.003 | 0.011 |
| GO:0044257 | 76 | 0.329 | 0.171 | Down | 0.036 | 0.079 | 0.005 | 0.014 |
| GO:0006099 | 17 | 0.118 | 0.294 | Up | 0.036 | 0.079 | 0.019 | 0.036 |
| GO:0051603 | 76 | 0.329 | 0.171 | Down | 0.036 | 0.080 | 0.005 | 0.014 |
| GO:0043244 | 3 | 0.667 | 0.333 | Down | 0.036 | 0.080 | 0.012 | 0.027 |
| GO:0044255 | 73 | 0.151 | 0.260 | Up | 0.037 | 0.080 | 0.007 | 0.018 |
| GO:0006750 | 3 | 0.000 | 0.667 | Up | 0.037 | 0.080 | 0.039 | 0.058 |
| GO:0043632 | 73 | 0.329 | 0.164 | Down | 0.037 | 0.080 | 0.006 | 0.015 |
| GO:0009147 | 3 | 0.000 | 0.333 | Up | 0.037 | 0.081 | 0.053 | 0.073 |
| GO:0097354 | 6 | 0.000 | 0.167 | Up | 0.037 | 0.081 | 0.170 | 0.199 |
| GO:0043043 | 3 | 0.000 | 0.667 | Up | 0.037 | 0.081 | 0.040 | 0.059 |
| GO:0018205 | 6 | 0.333 | 0.500 | Up | 0.037 | 0.081 | 0.011 | 0.024 |
| GO:0031324 | 6 | 0.333 | 0.167 | Down | 0.037 | 0.081 | 0.014 | 0.029 |
| GO:0034645 | 383 | 0.193 | 0.196 | Down | 0.038 | 0.081 | 0.003 | 0.011 |
| GO:0019184 | 3 | 0.000 | 0.667 | Up | 0.038 | 0.082 | 0.036 | 0.055 |
| GO:0015672 | 24 | 0.208 | 0.292 | Up | 0.038 | 0.082 | 0.002 | 0.010 |
| GO:0019941 | 73 | 0.329 | 0.164 | Down | 0.039 | 0.084 | 0.006 | 0.016 |
| GO:0018342 | 6 | 0.000 | 0.167 | Up | 0.040 | 0.084 | 0.168 | 0.198 |
| GO:0016310 | 99 | 0.121 | 0.162 | Up | 0.040 | 0.084 | 0.008 | 0.019 |
| GO:0006468 | 91 | 0.099 | 0.154 | Up | 0.040 | 0.084 | 0.013 | 0.028 |
| GO:0007059 | 8 | 0.000 | 0.375 | Up | 0.040 | 0.084 | 0.049 | 0.069 |
| GO:0009059 | 385 | 0.192 | 0.197 | Down | 0.040 | 0.084 | 0.001 | 0.008 |
| GO:0016570 | 11 | 0.273 | 0.273 | Down | 0.040 | 0.084 | 0.004 | 0.014 |
| GO:0046486 | 25 | 0.160 | 0.320 | Up | 0.040 | 0.085 | 0.005 | 0.015 |
| GO:0043038 | 40 | 0.350 | 0.200 | Down | 0.040 | 0.085 | 0.005 | 0.015 |
| GO:0018344 | 3 | 0.000 | 0.333 | Up | 0.040 | 0.085 | 0.097 | 0.119 |
| GO:0006091 | 41 | 0.317 | 0.146 | Down | 0.041 | 0.085 | 0.004 | 0.012 |
| GO:0044265 | 97 | 0.299 | 0.165 | Down | 0.041 | 0.085 | 0.004 | 0.013 |
| GO:0006166 | 2 | 1.000 | 0.000 | Down | 0.041 | 0.085 | 0.041 | 0.060 |
| GO:0032787 | 53 | 0.264 | 0.151 | Down | 0.041 | 0.085 | 0.010 | 0.023 |
| GO:0032269 | 1 | 0.000 | 1.000 | Up | 0.041 | 0.086 | 0.041 | 0.060 |
| GO:0043039 | 40 | 0.350 | 0.200 | Down | 0.042 | 0.086 | 0.006 | 0.016 |
| GO:0016569 | 11 | 0.273 | 0.273 | Down | 0.042 | 0.086 | 0.005 | 0.015 |
| GO:0006415 | 5 | 0.000 | 0.400 | Up | 0.042 | 0.086 | 0.147 | 0.174 |
| GO:0008652 | 20 | 0.150 | 0.200 | Down | 0.042 | 0.086 | 0.018 | 0.034 |
| GO:0043101 | 2 | 1.000 | 0.000 | Down | 0.042 | 0.086 | 0.042 | 0.061 |
| GO:1902578 | 203 | 0.153 | 0.182 | Up | 0.042 | 0.086 | 0.005 | 0.015 |
| GO:0006084 | 5 | 0.000 | 0.400 | Up | 0.042 | 0.087 | 0.056 | 0.076 |
| GO:0043174 | 2 | 1.000 | 0.000 | Down | 0.043 | 0.087 | 0.043 | 0.062 |
| GO:0043624 | 5 | 0.000 | 0.400 | Up | 0.043 | 0.087 | 0.143 | 0.169 |
| GO:0051248 | 1 | 0.000 | 1.000 | Up | 0.043 | 0.088 | 0.043 | 0.062 |
| GO:0072524 | 12 | 0.417 | 0.000 | Down | 0.044 | 0.088 | 0.074 | 0.095 |
| GO:0071103 | 19 | 0.316 | 0.211 | Down | 0.044 | 0.088 | 0.009 | 0.021 |
| GO:0009057 | 101 | 0.287 | 0.158 | Down | 0.044 | 0.088 | 0.006 | 0.017 |
| GO:1901135 | 97 | 0.175 | 0.258 | Up | 0.044 | 0.088 | 0.001 | 0.008 |
| GO:1901070 | 2 | 0.000 | 0.500 | Up | 0.044 | 0.088 | 0.013 | 0.028 |
| GO:0043650 | 3 | 0.333 | 0.000 | Down | 0.045 | 0.089 | 0.058 | 0.078 |
| GO:0030154 | 7 | 0.000 | 0.286 | Up | 0.045 | 0.090 | 0.065 | 0.087 |
| GO:0002376 | 7 | 0.286 | 0.000 | Down | 0.045 | 0.090 | 0.020 | 0.037 |
| GO:0032984 | 8 | 0.000 | 0.375 | Up | 0.046 | 0.091 | 0.055 | 0.075 |
| GO:0006473 | 6 | 0.000 | 0.500 | Up | 0.046 | 0.091 | 0.116 | 0.140 |
| GO:0022411 | 8 | 0.000 | 0.375 | Up | 0.046 | 0.092 | 0.053 | 0.073 |
| GO:0006412 | 231 | 0.229 | 0.173 | Down | 0.047 | 0.093 | 0.004 | 0.013 |
| GO:0030163 | 86 | 0.302 | 0.174 | Down | 0.047 | 0.093 | 0.004 | 0.012 |
| GO:0043484 | 2 | 0.500 | 0.000 | Down | 0.048 | 0.094 | 0.091 | 0.113 |
| GO:0051130 | 3 | 0.333 | 0.000 | Down | 0.048 | 0.094 | 0.166 | 0.195 |
| GO:0009991 | 7 | 0.429 | 0.143 | Down | 0.048 | 0.094 | 0.019 | 0.036 |
| GO:0001522 | 17 | 0.059 | 0.176 | Up | 0.048 | 0.094 | 0.051 | 0.071 |
| GO:0031365 | 4 | 0.250 | 0.000 | Down | 0.048 | 0.094 | 0.069 | 0.090 |
| GO:0018345 | 8 | 0.000 | 0.500 | Up | 0.049 | 0.095 | 0.068 | 0.090 |
| GO:0040011 | 58 | 0.155 | 0.207 | Up | 0.049 | 0.095 | 0.004 | 0.013 |
| GO:0044765 | 199 | 0.156 | 0.176 | Up | 0.049 | 0.095 | 0.003 | 0.011 |
| GO:0006400 | 19 | 0.105 | 0.263 | Up | 0.049 | 0.095 | 0.003 | 0.011 |
| GO:0006420 | 3 | 0.000 | 0.667 | Up | 0.049 | 0.095 | 0.146 | 0.172 |
| GO:0051252 | 87 | 0.195 | 0.161 | Down | 0.049 | 0.095 | 0.010 | 0.023 |
| GO:0006749 | 4 | 0.250 | 0.500 | Up | 0.050 | 0.096 | 0.012 | 0.026 |
| GO:0006260 | 47 | 0.106 | 0.170 | Up | 0.050 | 0.096 | 0.020 | 0.037 |
| GO:0044248 | 137 | 0.255 | 0.161 | Down | 0.050 | 0.096 | 0.005 | 0.014 |
| GO:0046165 | 6 | 0.167 | 0.000 | Down | 0.051 | 0.097 | 0.079 | 0.101 |
| GO:0006793 | 226 | 0.159 | 0.186 | Up | 0.052 | 0.099 | 0.003 | 0.012 |
| GO:0009218 | 2 | 0.000 | 0.500 | Up | 0.053 | 0.102 | 0.018 | 0.035 |
| GO:0006275 | 3 | 0.000 | 0.333 | Up | 0.054 | 0.102 | 0.085 | 0.107 |
| GO:0051649 | 138 | 0.188 | 0.109 | Down | 0.054 | 0.102 | 0.006 | 0.015 |
| GO:0046131 | 2 | 0.000 | 0.500 | Up | 0.054 | 0.102 | 0.015 | 0.030 |
| GO:0051028 | 4 | 0.250 | 0.250 | Down | 0.054 | 0.102 | 0.033 | 0.053 |
| GO:0051641 | 142 | 0.183 | 0.120 | Down | 0.054 | 0.102 | 0.003 | 0.012 |
| GO:0030433 | 19 | 0.158 | 0.211 | Up | 0.054 | 0.102 | 0.027 | 0.047 |
| GO:0015748 | 6 | 0.167 | 0.167 | Down | 0.054 | 0.102 | 0.003 | 0.010 |
| GO:0055086 | 85 | 0.235 | 0.141 | Down | 0.055 | 0.102 | 0.004 | 0.012 |
| GO:0023051 | 21 | 0.238 | 0.286 | Up | 0.055 | 0.102 | 0.001 | 0.006 |
| GO:0006383 | 7 | 0.286 | 0.143 | Down | 0.055 | 0.103 | 0.006 | 0.017 |
| GO:0034982 | 2 | 0.500 | 0.000 | Down | 0.055 | 0.103 | 0.056 | 0.076 |
| GO:0052126 | 54 | 0.167 | 0.185 | Up | 0.055 | 0.103 | 0.004 | 0.013 |
| GO:0042273 | 16 | 0.250 | 0.125 | Down | 0.056 | 0.104 | 0.035 | 0.054 |
| GO:0009966 | 21 | 0.238 | 0.286 | Up | 0.056 | 0.104 | 0.001 | 0.006 |
| GO:0052192 | 54 | 0.167 | 0.185 | Up | 0.056 | 0.104 | 0.004 | 0.012 |
| GO:0033013 | 8 | 0.000 | 0.375 | Up | 0.056 | 0.104 | 0.079 | 0.101 |
| GO:0010646 | 21 | 0.238 | 0.286 | Up | 0.056 | 0.104 | 0.001 | 0.006 |
| GO:0046134 | 2 | 0.000 | 0.500 | Up | 0.057 | 0.105 | 0.019 | 0.036 |
| GO:0009220 | 2 | 0.000 | 0.500 | Up | 0.057 | 0.105 | 0.017 | 0.032 |
| GO:0006367 | 8 | 0.000 | 0.375 | Up | 0.057 | 0.105 | 0.036 | 0.055 |
| GO:0020027 | 7 | 0.143 | 0.286 | Up | 0.058 | 0.106 | 0.010 | 0.023 |
| GO:0006388 | 2 | 0.000 | 0.500 | Up | 0.058 | 0.106 | 0.067 | 0.089 |
| GO:0031325 | 4 | 0.500 | 0.250 | Down | 0.058 | 0.106 | 0.013 | 0.028 |
| GO:0000394 | 2 | 0.000 | 0.500 | Up | 0.058 | 0.106 | 0.075 | 0.096 |
| GO:0046132 | 2 | 0.000 | 0.500 | Up | 0.058 | 0.106 | 0.015 | 0.030 |
| GO:0010604 | 4 | 0.500 | 0.250 | Down | 0.059 | 0.106 | 0.016 | 0.032 |
| GO:0042168 | 8 | 0.000 | 0.375 | Up | 0.059 | 0.106 | 0.086 | 0.108 |
| GO:0006656 | 4 | 0.250 | 0.000 | Down | 0.059 | 0.106 | 0.038 | 0.057 |
| GO:1902589 | 44 | 0.182 | 0.159 | Down | 0.059 | 0.106 | 0.003 | 0.012 |
| GO:0008104 | 148 | 0.189 | 0.128 | Down | 0.059 | 0.106 | 0.007 | 0.017 |
| GO:0006213 | 2 | 0.000 | 0.500 | Up | 0.060 | 0.107 | 0.017 | 0.032 |
| GO:0009127 | 11 | 0.091 | 0.364 | Up | 0.060 | 0.107 | 0.051 | 0.071 |
| GO:0015980 | 24 | 0.125 | 0.250 | Up | 0.060 | 0.107 | 0.030 | 0.050 |
| GO:0006650 | 24 | 0.167 | 0.333 | Up | 0.060 | 0.107 | 0.005 | 0.015 |
| GO:0042594 | 3 | 0.667 | 0.000 | Down | 0.060 | 0.107 | 0.044 | 0.063 |
| GO:0042440 | 8 | 0.000 | 0.375 | Up | 0.060 | 0.107 | 0.084 | 0.107 |
| GO:0006811 | 79 | 0.177 | 0.190 | Down | 0.061 | 0.108 | 0.003 | 0.011 |
| GO:0042439 | 4 | 0.250 | 0.000 | Down | 0.061 | 0.108 | 0.037 | 0.056 |
| GO:0046470 | 4 | 0.250 | 0.000 | Down | 0.061 | 0.108 | 0.032 | 0.052 |
| GO:0031668 | 5 | 0.400 | 0.000 | Down | 0.061 | 0.108 | 0.115 | 0.139 |
| GO:0043094 | 3 | 0.667 | 0.000 | Down | 0.062 | 0.109 | 0.092 | 0.114 |
| GO:0051806 | 42 | 0.167 | 0.214 | Up | 0.062 | 0.109 | 0.002 | 0.009 |
| GO:0046395 | 7 | 0.143 | 0.429 | Up | 0.062 | 0.109 | 0.062 | 0.083 |
| GO:0016054 | 7 | 0.143 | 0.429 | Up | 0.063 | 0.110 | 0.067 | 0.089 |
| GO:0009168 | 11 | 0.091 | 0.364 | Up | 0.063 | 0.110 | 0.056 | 0.076 |
| GO:0022402 | 21 | 0.095 | 0.190 | Up | 0.063 | 0.110 | 0.056 | 0.076 |
| GO:0006778 | 8 | 0.000 | 0.375 | Up | 0.063 | 0.110 | 0.085 | 0.107 |
| GO:0045333 | 23 | 0.130 | 0.261 | Up | 0.063 | 0.110 | 0.029 | 0.049 |
| GO:0048869 | 8 | 0.000 | 0.250 | Up | 0.063 | 0.110 | 0.077 | 0.098 |
| GO:0071702 | 174 | 0.178 | 0.126 | Down | 0.063 | 0.110 | 0.009 | 0.021 |
| GO:0034033 | 4 | 0.000 | 0.250 | Up | 0.064 | 0.110 | 0.042 | 0.061 |
| GO:0030260 | 42 | 0.167 | 0.214 | Up | 0.064 | 0.110 | 0.003 | 0.011 |
| GO:0017038 | 19 | 0.263 | 0.053 | Down | 0.064 | 0.110 | 0.054 | 0.074 |
| GO:2001141 | 85 | 0.188 | 0.165 | Down | 0.065 | 0.110 | 0.010 | 0.022 |
| GO:0042540 | 7 | 0.143 | 0.286 | Up | 0.065 | 0.110 | 0.012 | 0.026 |
| GO:0034030 | 4 | 0.000 | 0.250 | Up | 0.065 | 0.110 | 0.041 | 0.060 |
| GO:0015936 | 4 | 0.000 | 0.250 | Up | 0.065 | 0.110 | 0.041 | 0.060 |
| GO:0030488 | 4 | 0.000 | 0.250 | Up | 0.065 | 0.110 | 0.050 | 0.069 |
| GO:0046907 | 134 | 0.179 | 0.112 | Down | 0.065 | 0.110 | 0.006 | 0.016 |
| GO:0051179 | 346 | 0.171 | 0.159 | Up | 0.065 | 0.110 | 0.004 | 0.013 |
| GO:0015711 | 18 | 0.167 | 0.111 | Down | 0.065 | 0.110 | 0.010 | 0.022 |
| GO:0045184 | 143 | 0.189 | 0.119 | Down | 0.065 | 0.110 | 0.008 | 0.020 |
| GO:0006418 | 38 | 0.342 | 0.211 | Down | 0.066 | 0.111 | 0.007 | 0.018 |
| GO:0009893 | 4 | 0.500 | 0.250 | Down | 0.066 | 0.111 | 0.016 | 0.032 |
| GO:0033866 | 4 | 0.000 | 0.250 | Up | 0.066 | 0.111 | 0.041 | 0.060 |
| GO:0033875 | 4 | 0.000 | 0.250 | Up | 0.066 | 0.111 | 0.041 | 0.060 |
| GO:0072528 | 14 | 0.286 | 0.143 | Down | 0.066 | 0.111 | 0.001 | 0.007 |
| GO:0044282 | 7 | 0.143 | 0.429 | Up | 0.066 | 0.111 | 0.065 | 0.087 |
| GO:0016311 | 15 | 0.200 | 0.267 | Down | 0.066 | 0.111 | 0.007 | 0.018 |
| GO:0015031 | 142 | 0.190 | 0.120 | Down | 0.066 | 0.111 | 0.007 | 0.018 |
| GO:0034032 | 4 | 0.000 | 0.250 | Up | 0.067 | 0.112 | 0.038 | 0.057 |
| GO:0033865 | 4 | 0.000 | 0.250 | Up | 0.067 | 0.112 | 0.044 | 0.063 |
| GO:0055085 | 69 | 0.174 | 0.188 | Up | 0.067 | 0.112 | 0.006 | 0.016 |
| GO:0006355 | 85 | 0.188 | 0.165 | Down | 0.068 | 0.113 | 0.012 | 0.026 |
| GO:0009148 | 2 | 0.000 | 0.500 | Up | 0.068 | 0.113 | 0.045 | 0.064 |
| GO:0044409 | 46 | 0.174 | 0.196 | Up | 0.068 | 0.113 | 0.003 | 0.011 |
| GO:0030522 | 2 | 0.500 | 0.000 | Down | 0.069 | 0.114 | 0.020 | 0.037 |
| GO:0006733 | 15 | 0.333 | 0.133 | Down | 0.070 | 0.115 | 0.022 | 0.039 |
| GO:0002682 | 6 | 0.333 | 0.000 | Down | 0.070 | 0.115 | 0.024 | 0.043 |
| GO:0046916 | 3 | 0.333 | 0.667 | Up | 0.070 | 0.115 | 0.005 | 0.014 |
| GO:0015937 | 4 | 0.000 | 0.250 | Up | 0.070 | 0.115 | 0.045 | 0.064 |
| GO:0060627 | 23 | 0.087 | 0.261 | Up | 0.071 | 0.115 | 0.003 | 0.011 |
| GO:0019637 | 115 | 0.217 | 0.191 | Down | 0.071 | 0.115 | 0.002 | 0.009 |
| GO:0015693 | 1 | 0.000 | 1.000 | Up | 0.071 | 0.116 | 0.071 | 0.092 |
| GO:0071496 | 5 | 0.400 | 0.000 | Down | 0.071 | 0.116 | 0.116 | 0.140 |
| GO:0017004 | 2 | 0.500 | 0.500 | Up | 0.071 | 0.116 | 0.030 | 0.049 |
| GO:0000393 | 5 | 0.400 | 0.400 | Down | 0.071 | 0.116 | 0.008 | 0.019 |
| GO:0006887 | 5 | 0.400 | 0.200 | Down | 0.071 | 0.116 | 0.000 | 0.005 |
| GO:0071822 | 51 | 0.235 | 0.196 | Down | 0.071 | 0.116 | 0.004 | 0.013 |
| GO:0042180 | 6 | 0.000 | 0.333 | Up | 0.072 | 0.116 | 0.067 | 0.089 |
| GO:0009150 | 40 | 0.150 | 0.250 | Up | 0.072 | 0.116 | 0.003 | 0.011 |
| GO:0051828 | 46 | 0.174 | 0.196 | Up | 0.073 | 0.117 | 0.002 | 0.009 |
| GO:0046903 | 5 | 0.400 | 0.200 | Down | 0.074 | 0.119 | 0.000 | 0.004 |
| GO:0050776 | 6 | 0.333 | 0.000 | Down | 0.074 | 0.119 | 0.022 | 0.040 |
| GO:0055076 | 3 | 0.333 | 0.667 | Up | 0.075 | 0.120 | 0.005 | 0.015 |
| GO:0032940 | 5 | 0.400 | 0.200 | Down | 0.075 | 0.120 | 0.000 | 0.004 |
| GO:0042181 | 6 | 0.000 | 0.333 | Up | 0.075 | 0.120 | 0.072 | 0.093 |
| GO:0006886 | 102 | 0.196 | 0.108 | Down | 0.076 | 0.121 | 0.009 | 0.021 |
| GO:0034613 | 106 | 0.189 | 0.123 | Down | 0.077 | 0.122 | 0.007 | 0.017 |
| GO:0051234 | 333 | 0.171 | 0.150 | Up | 0.077 | 0.122 | 0.004 | 0.012 |
| GO:0070727 | 106 | 0.189 | 0.123 | Down | 0.078 | 0.123 | 0.007 | 0.018 |
| GO:1901661 | 6 | 0.000 | 0.333 | Up | 0.078 | 0.124 | 0.077 | 0.098 |
| GO:0006796 | 219 | 0.164 | 0.178 | Up | 0.078 | 0.124 | 0.003 | 0.012 |
| GO:0006810 | 332 | 0.172 | 0.151 | Up | 0.079 | 0.125 | 0.004 | 0.013 |
| GO:0006487 | 2 | 0.000 | 0.500 | Up | 0.080 | 0.126 | 0.172 | 0.202 |
| GO:0017183 | 5 | 0.200 | 0.400 | Up | 0.081 | 0.127 | 0.016 | 0.032 |
| GO:0007017 | 31 | 0.194 | 0.194 | Up | 0.081 | 0.127 | 0.003 | 0.012 |
| GO:0009124 | 12 | 0.083 | 0.333 | Up | 0.081 | 0.127 | 0.058 | 0.079 |
| GO:1901663 | 6 | 0.000 | 0.333 | Up | 0.082 | 0.128 | 0.075 | 0.096 |
| GO:0048870 | 10 | 0.100 | 0.300 | Up | 0.082 | 0.128 | 0.050 | 0.069 |
| GO:0055114 | 95 | 0.211 | 0.221 | Up | 0.082 | 0.128 | 0.001 | 0.007 |
| GO:0006873 | 11 | 0.091 | 0.364 | Up | 0.082 | 0.128 | 0.014 | 0.029 |
| GO:0030003 | 11 | 0.091 | 0.364 | Up | 0.083 | 0.129 | 0.014 | 0.029 |
| GO:0009156 | 12 | 0.083 | 0.333 | Up | 0.084 | 0.131 | 0.061 | 0.082 |
| GO:0009259 | 41 | 0.146 | 0.244 | Up | 0.084 | 0.131 | 0.004 | 0.013 |
| GO:0046034 | 12 | 0.167 | 0.417 | Up | 0.084 | 0.131 | 0.029 | 0.049 |
| GO:0051674 | 10 | 0.100 | 0.300 | Up | 0.086 | 0.132 | 0.053 | 0.073 |
| GO:0017182 | 5 | 0.200 | 0.400 | Up | 0.086 | 0.132 | 0.016 | 0.031 |
| GO:0007186 | 4 | 0.000 | 0.250 | Up | 0.087 | 0.135 | 0.175 | 0.205 |
| GO:0006366 | 21 | 0.143 | 0.238 | Up | 0.088 | 0.135 | 0.015 | 0.029 |
| GO:0031667 | 4 | 0.500 | 0.250 | Down | 0.088 | 0.136 | 0.007 | 0.018 |
| GO:0019693 | 42 | 0.143 | 0.238 | Up | 0.089 | 0.136 | 0.004 | 0.014 |
| GO:0015988 | 14 | 0.214 | 0.357 | Up | 0.089 | 0.136 | 0.003 | 0.012 |
| GO:0034227 | 3 | 0.000 | 0.333 | Up | 0.089 | 0.137 | 0.136 | 0.161 |
| GO:0015991 | 14 | 0.214 | 0.357 | Up | 0.090 | 0.138 | 0.003 | 0.011 |
| GO:0006826 | 3 | 0.333 | 0.000 | Down | 0.091 | 0.138 | 0.069 | 0.090 |
| GO:0046488 | 18 | 0.167 | 0.333 | Up | 0.091 | 0.138 | 0.010 | 0.023 |
| GO:0098655 | 17 | 0.176 | 0.294 | Up | 0.091 | 0.139 | 0.009 | 0.021 |
| GO:1901657 | 48 | 0.208 | 0.229 | Down | 0.092 | 0.139 | 0.001 | 0.007 |
| GO:0048878 | 14 | 0.143 | 0.357 | Up | 0.092 | 0.140 | 0.005 | 0.015 |
| GO:0015684 | 3 | 0.333 | 0.000 | Down | 0.093 | 0.140 | 0.072 | 0.093 |
| GO:0030150 | 3 | 0.667 | 0.000 | Down | 0.094 | 0.142 | 0.043 | 0.062 |
| GO:0009199 | 30 | 0.167 | 0.300 | Up | 0.095 | 0.144 | 0.002 | 0.010 |
| GO:0034220 | 19 | 0.211 | 0.263 | Up | 0.096 | 0.144 | 0.001 | 0.006 |
| GO:0098660 | 17 | 0.176 | 0.294 | Up | 0.097 | 0.146 | 0.010 | 0.023 |
| GO:0070271 | 42 | 0.262 | 0.190 | Down | 0.097 | 0.146 | 0.006 | 0.015 |
| GO:0051259 | 6 | 0.167 | 0.167 | Up | 0.097 | 0.146 | 0.027 | 0.046 |
| GO:0098662 | 17 | 0.176 | 0.294 | Up | 0.098 | 0.146 | 0.010 | 0.023 |
| GO:0006461 | 42 | 0.262 | 0.190 | Down | 0.098 | 0.146 | 0.005 | 0.015 |
| GO:0006817 | 22 | 0.136 | 0.045 | Down | 0.100 | 0.149 | 0.261 | 0.292 |
| GO:0006334 | 6 | 0.333 | 0.333 | Down | 0.100 | 0.149 | 0.020 | 0.037 |
| GO:0009205 | 30 | 0.167 | 0.300 | Up | 0.100 | 0.149 | 0.002 | 0.010 |
| GO:0030258 | 4 | 0.250 | 0.250 | Down | 0.100 | 0.149 | 0.064 | 0.085 |
| GO:0034728 | 6 | 0.333 | 0.333 | Down | 0.101 | 0.149 | 0.022 | 0.040 |
| GO:0000278 | 13 | 0.000 | 0.154 | Up | 0.101 | 0.149 | 0.246 | 0.276 |
| GO:0006665 | 2 | 0.000 | 1.000 | Up | 0.101 | 0.150 | 0.103 | 0.127 |
| GO:0044283 | 59 | 0.119 | 0.186 | Up | 0.102 | 0.151 | 0.012 | 0.026 |
| GO:1901615 | 13 | 0.154 | 0.000 | Down | 0.104 | 0.153 | 0.231 | 0.261 |
| GO:0071705 | 16 | 0.188 | 0.125 | Down | 0.105 | 0.154 | 0.024 | 0.043 |
| GO:0071824 | 11 | 0.273 | 0.182 | Down | 0.105 | 0.154 | 0.043 | 0.062 |
| GO:0007166 | 8 | 0.125 | 0.125 | Up | 0.105 | 0.154 | 0.036 | 0.056 |
| GO:0065004 | 11 | 0.273 | 0.182 | Down | 0.105 | 0.154 | 0.043 | 0.062 |
| GO:0009116 | 47 | 0.213 | 0.234 | Down | 0.106 | 0.154 | 0.002 | 0.008 |
| GO:0009117 | 71 | 0.211 | 0.155 | Down | 0.106 | 0.154 | 0.004 | 0.013 |
| GO:0006825 | 3 | 0.000 | 0.333 | Up | 0.106 | 0.154 | 0.113 | 0.138 |
| GO:0010256 | 4 | 0.000 | 0.250 | Up | 0.106 | 0.154 | 0.189 | 0.219 |
| GO:0006310 | 18 | 0.167 | 0.111 | Down | 0.106 | 0.154 | 0.020 | 0.037 |
| GO:0006220 | 8 | 0.250 | 0.125 | Up | 0.107 | 0.155 | 0.032 | 0.052 |
| GO:0015074 | 3 | 0.333 | 0.000 | Down | 0.108 | 0.156 | 0.120 | 0.144 |
| GO:0009165 | 36 | 0.194 | 0.194 | Up | 0.108 | 0.156 | 0.002 | 0.010 |
| GO:0006376 | 3 | 0.333 | 0.333 | Down | 0.108 | 0.156 | 0.033 | 0.053 |
| GO:0000003 | 3 | 0.333 | 0.000 | Down | 0.108 | 0.156 | 0.172 | 0.202 |
| GO:0032483 | 13 | 0.231 | 0.231 | Down | 0.109 | 0.157 | 0.008 | 0.019 |
| GO:0072527 | 15 | 0.267 | 0.133 | Up | 0.109 | 0.157 | 0.003 | 0.011 |
| GO:0055082 | 12 | 0.083 | 0.333 | Up | 0.109 | 0.157 | 0.017 | 0.032 |
| GO:0032313 | 13 | 0.231 | 0.231 | Down | 0.109 | 0.157 | 0.009 | 0.021 |
| GO:1901293 | 37 | 0.189 | 0.189 | Up | 0.111 | 0.158 | 0.003 | 0.011 |
| GO:0015698 | 23 | 0.130 | 0.087 | Down | 0.111 | 0.159 | 0.214 | 0.243 |
| GO:0050801 | 12 | 0.167 | 0.333 | Up | 0.112 | 0.160 | 0.005 | 0.014 |
| GO:0055080 | 12 | 0.167 | 0.333 | Up | 0.113 | 0.160 | 0.005 | 0.015 |
| GO:1901565 | 31 | 0.161 | 0.161 | Down | 0.113 | 0.161 | 0.033 | 0.053 |
| GO:0016192 | 83 | 0.145 | 0.157 | Up | 0.113 | 0.161 | 0.009 | 0.021 |
| GO:1902600 | 16 | 0.188 | 0.312 | Up | 0.114 | 0.161 | 0.008 | 0.020 |
| GO:0010498 | 21 | 0.190 | 0.190 | Up | 0.114 | 0.162 | 0.030 | 0.050 |
| GO:0006766 | 8 | 0.125 | 0.250 | Up | 0.116 | 0.164 | 0.034 | 0.054 |
| GO:0043161 | 21 | 0.190 | 0.190 | Up | 0.117 | 0.165 | 0.033 | 0.053 |
| GO:0007154 | 59 | 0.169 | 0.102 | Down | 0.119 | 0.168 | 0.013 | 0.027 |
| GO:0006352 | 14 | 0.071 | 0.286 | Up | 0.120 | 0.168 | 0.031 | 0.051 |
| GO:0045047 | 7 | 0.143 | 0.143 | Down | 0.120 | 0.168 | 0.048 | 0.067 |
| GO:0006163 | 43 | 0.163 | 0.233 | Up | 0.120 | 0.168 | 0.003 | 0.010 |
| GO:0009144 | 31 | 0.194 | 0.290 | Up | 0.120 | 0.169 | 0.002 | 0.009 |
| GO:0072599 | 7 | 0.143 | 0.143 | Down | 0.122 | 0.171 | 0.047 | 0.066 |
| GO:0006612 | 7 | 0.143 | 0.143 | Down | 0.122 | 0.171 | 0.047 | 0.067 |
| GO:1903047 | 12 | 0.000 | 0.167 | Up | 0.123 | 0.171 | 0.282 | 0.313 |
| GO:0051260 | 3 | 0.333 | 0.000 | Down | 0.123 | 0.172 | 0.219 | 0.249 |
| GO:0042364 | 8 | 0.125 | 0.250 | Up | 0.125 | 0.174 | 0.038 | 0.057 |
| GO:0043623 | 26 | 0.308 | 0.192 | Down | 0.126 | 0.175 | 0.007 | 0.018 |
| GO:0009262 | 7 | 0.143 | 0.143 | Up | 0.126 | 0.175 | 0.030 | 0.049 |
| GO:0006767 | 8 | 0.125 | 0.250 | Up | 0.126 | 0.175 | 0.039 | 0.059 |
| GO:0008295 | 3 | 0.000 | 0.333 | Up | 0.128 | 0.177 | 0.072 | 0.093 |
| GO:0009110 | 8 | 0.125 | 0.250 | Up | 0.128 | 0.178 | 0.041 | 0.060 |
| GO:0042401 | 3 | 0.000 | 0.333 | Up | 0.132 | 0.182 | 0.073 | 0.094 |
| GO:1902582 | 80 | 0.162 | 0.125 | Down | 0.132 | 0.182 | 0.017 | 0.032 |
| GO:0006753 | 73 | 0.205 | 0.151 | Down | 0.132 | 0.182 | 0.005 | 0.014 |
| GO:0006596 | 3 | 0.000 | 0.333 | Up | 0.132 | 0.182 | 0.076 | 0.097 |
| GO:0006261 | 27 | 0.148 | 0.222 | Up | 0.133 | 0.182 | 0.035 | 0.054 |
| GO:0016567 | 11 | 0.182 | 0.182 | Down | 0.133 | 0.182 | 0.021 | 0.039 |
| GO:0019751 | 3 | 0.333 | 0.000 | Down | 0.134 | 0.183 | 0.241 | 0.270 |
| GO:0006744 | 5 | 0.000 | 0.400 | Up | 0.134 | 0.184 | 0.096 | 0.118 |
| GO:0009309 | 3 | 0.000 | 0.333 | Up | 0.135 | 0.184 | 0.073 | 0.094 |
| GO:0006743 | 5 | 0.000 | 0.400 | Up | 0.137 | 0.187 | 0.105 | 0.128 |
| GO:0009119 | 46 | 0.196 | 0.239 | Down | 0.137 | 0.187 | 0.001 | 0.008 |
| GO:0051258 | 8 | 0.000 | 0.250 | Up | 0.137 | 0.187 | 0.269 | 0.301 |
| GO:0006536 | 5 | 0.200 | 0.000 | Down | 0.139 | 0.188 | 0.096 | 0.119 |
| GO:0009141 | 34 | 0.176 | 0.265 | Up | 0.139 | 0.188 | 0.005 | 0.015 |
| GO:1901617 | 9 | 0.111 | 0.000 | Down | 0.139 | 0.189 | 0.207 | 0.238 |
| GO:0006772 | 4 | 0.250 | 0.250 | Up | 0.139 | 0.189 | 0.031 | 0.051 |
| GO:0043413 | 7 | 0.000 | 0.286 | Up | 0.140 | 0.189 | 0.212 | 0.242 |
| GO:0009228 | 4 | 0.250 | 0.250 | Up | 0.142 | 0.192 | 0.034 | 0.053 |
| GO:0046128 | 41 | 0.171 | 0.244 | Up | 0.143 | 0.192 | 0.003 | 0.012 |
| GO:0042278 | 41 | 0.171 | 0.244 | Up | 0.143 | 0.192 | 0.004 | 0.013 |
| GO:0006323 | 10 | 0.200 | 0.200 | Down | 0.143 | 0.192 | 0.056 | 0.077 |
| GO:0009263 | 4 | 0.000 | 0.250 | Up | 0.143 | 0.192 | 0.056 | 0.076 |
| GO:0006486 | 7 | 0.000 | 0.286 | Up | 0.144 | 0.192 | 0.207 | 0.238 |
| GO:0042724 | 4 | 0.250 | 0.250 | Up | 0.144 | 0.192 | 0.033 | 0.053 |
| GO:0032392 | 6 | 0.333 | 0.167 | Down | 0.145 | 0.193 | 0.071 | 0.092 |
| GO:0009101 | 7 | 0.000 | 0.286 | Up | 0.145 | 0.193 | 0.207 | 0.238 |
| GO:0042723 | 4 | 0.250 | 0.250 | Up | 0.146 | 0.194 | 0.033 | 0.053 |
| GO:0070085 | 7 | 0.000 | 0.286 | Up | 0.146 | 0.194 | 0.212 | 0.242 |
| GO:0044262 | 11 | 0.273 | 0.091 | Down | 0.146 | 0.194 | 0.098 | 0.121 |
| GO:0009100 | 7 | 0.000 | 0.286 | Up | 0.147 | 0.195 | 0.212 | 0.242 |
| GO:0008643 | 4 | 0.000 | 0.250 | Up | 0.148 | 0.195 | 0.271 | 0.302 |
| GO:0007165 | 54 | 0.148 | 0.111 | Up | 0.148 | 0.196 | 0.016 | 0.032 |
| GO:0032508 | 6 | 0.333 | 0.167 | Down | 0.149 | 0.196 | 0.070 | 0.091 |
| GO:0006470 | 11 | 0.182 | 0.364 | Up | 0.149 | 0.196 | 0.020 | 0.037 |
| GO:0023052 | 54 | 0.148 | 0.111 | Up | 0.150 | 0.197 | 0.014 | 0.028 |
| GO:0006401 | 10 | 0.200 | 0.100 | Down | 0.150 | 0.197 | 0.090 | 0.113 |
| GO:0010639 | 3 | 0.333 | 0.333 | Down | 0.150 | 0.197 | 0.034 | 0.054 |
| GO:0006432 | 3 | 0.333 | 0.000 | Up | 0.151 | 0.197 | 0.082 | 0.104 |
| GO:0051494 | 3 | 0.333 | 0.333 | Down | 0.151 | 0.197 | 0.038 | 0.057 |
| GO:0018202 | 6 | 0.167 | 0.333 | Up | 0.151 | 0.197 | 0.045 | 0.064 |
| GO:1901658 | 19 | 0.158 | 0.158 | Down | 0.151 | 0.198 | 0.032 | 0.052 |
| GO:0006631 | 29 | 0.103 | 0.172 | Up | 0.152 | 0.198 | 0.226 | 0.255 |
| GO:0042454 | 19 | 0.158 | 0.158 | Down | 0.152 | 0.198 | 0.028 | 0.047 |
| GO:0019439 | 37 | 0.162 | 0.108 | Down | 0.152 | 0.198 | 0.036 | 0.055 |
| GO:0044700 | 54 | 0.148 | 0.111 | Up | 0.154 | 0.200 | 0.015 | 0.030 |
| GO:0006152 | 19 | 0.158 | 0.158 | Down | 0.154 | 0.200 | 0.030 | 0.050 |
| GO:0046130 | 19 | 0.158 | 0.158 | Down | 0.155 | 0.201 | 0.032 | 0.052 |
| GO:1901361 | 39 | 0.154 | 0.103 | Down | 0.157 | 0.203 | 0.036 | 0.056 |
| GO:0030837 | 3 | 0.333 | 0.333 | Down | 0.157 | 0.203 | 0.038 | 0.057 |
| GO:0032446 | 18 | 0.167 | 0.167 | Down | 0.158 | 0.203 | 0.022 | 0.040 |
| GO:0009207 | 17 | 0.176 | 0.176 | Down | 0.159 | 0.204 | 0.024 | 0.042 |
| GO:0031333 | 3 | 0.333 | 0.333 | Down | 0.159 | 0.204 | 0.037 | 0.057 |
| GO:0046700 | 39 | 0.154 | 0.103 | Down | 0.159 | 0.204 | 0.040 | 0.060 |
| GO:0048193 | 26 | 0.115 | 0.192 | Up | 0.160 | 0.204 | 0.028 | 0.048 |
| GO:0051129 | 3 | 0.333 | 0.333 | Down | 0.160 | 0.204 | 0.040 | 0.059 |
| GO:0000956 | 5 | 0.200 | 0.000 | Down | 0.160 | 0.204 | 0.279 | 0.310 |
| GO:1901069 | 17 | 0.176 | 0.176 | Down | 0.160 | 0.204 | 0.020 | 0.037 |
| GO:0032272 | 3 | 0.333 | 0.333 | Down | 0.160 | 0.204 | 0.038 | 0.058 |
| GO:0031497 | 7 | 0.286 | 0.286 | Down | 0.161 | 0.205 | 0.027 | 0.047 |
| GO:0009146 | 17 | 0.176 | 0.176 | Down | 0.162 | 0.206 | 0.024 | 0.042 |
| GO:0072523 | 19 | 0.158 | 0.158 | Down | 0.162 | 0.206 | 0.033 | 0.053 |
| GO:0006195 | 18 | 0.167 | 0.167 | Down | 0.162 | 0.206 | 0.028 | 0.047 |
| GO:0009164 | 19 | 0.158 | 0.158 | Down | 0.162 | 0.206 | 0.029 | 0.049 |
| GO:0009261 | 18 | 0.167 | 0.167 | Down | 0.163 | 0.206 | 0.029 | 0.049 |
| GO:0048522 | 8 | 0.250 | 0.125 | Down | 0.163 | 0.206 | 0.075 | 0.096 |
| GO:0009154 | 18 | 0.167 | 0.167 | Down | 0.164 | 0.207 | 0.027 | 0.047 |
| GO:0006184 | 17 | 0.176 | 0.176 | Down | 0.164 | 0.207 | 0.023 | 0.041 |
| GO:0034655 | 35 | 0.171 | 0.114 | Down | 0.165 | 0.208 | 0.033 | 0.053 |
| GO:0000041 | 7 | 0.143 | 0.143 | Up | 0.165 | 0.208 | 0.034 | 0.054 |
| GO:0009203 | 17 | 0.176 | 0.176 | Down | 0.167 | 0.210 | 0.020 | 0.037 |
| GO:0006544 | 4 | 0.000 | 0.500 | Up | 0.168 | 0.210 | 0.196 | 0.227 |
| GO:0044270 | 39 | 0.154 | 0.103 | Down | 0.168 | 0.210 | 0.043 | 0.062 |
| GO:0015992 | 19 | 0.211 | 0.263 | Up | 0.169 | 0.211 | 0.006 | 0.015 |
| GO:0006446 | 9 | 0.222 | 0.222 | Up | 0.170 | 0.212 | 0.022 | 0.040 |
| GO:1901136 | 23 | 0.174 | 0.130 | Down | 0.171 | 0.213 | 0.042 | 0.060 |
| GO:0006818 | 19 | 0.211 | 0.263 | Up | 0.172 | 0.215 | 0.006 | 0.017 |
| GO:0006284 | 4 | 0.500 | 0.000 | Down | 0.172 | 0.215 | 0.087 | 0.109 |
| GO:0051052 | 4 | 0.000 | 0.250 | Up | 0.174 | 0.216 | 0.067 | 0.089 |
| GO:0006298 | 8 | 0.000 | 0.250 | Up | 0.177 | 0.220 | 0.213 | 0.242 |
| GO:0070838 | 6 | 0.333 | 0.333 | Down | 0.178 | 0.220 | 0.011 | 0.023 |
| GO:0070972 | 8 | 0.125 | 0.250 | Down | 0.181 | 0.224 | 0.023 | 0.041 |
| GO:0043604 | 5 | 0.000 | 0.400 | Up | 0.182 | 0.225 | 0.121 | 0.145 |
| GO:0072511 | 6 | 0.333 | 0.333 | Down | 0.183 | 0.226 | 0.012 | 0.025 |
| GO:0051169 | 25 | 0.160 | 0.040 | Down | 0.183 | 0.226 | 0.195 | 0.226 |
| GO:0006118 | 4 | 0.000 | 0.250 | Up | 0.186 | 0.229 | 0.313 | 0.344 |
| GO:0006913 | 25 | 0.160 | 0.040 | Down | 0.187 | 0.230 | 0.199 | 0.230 |
| GO:1901068 | 19 | 0.158 | 0.211 | Down | 0.188 | 0.231 | 0.008 | 0.020 |
| GO:0008216 | 4 | 0.250 | 0.250 | Down | 0.188 | 0.231 | 0.044 | 0.063 |
| GO:0072521 | 48 | 0.188 | 0.208 | Up | 0.190 | 0.233 | 0.003 | 0.011 |
| GO:0006434 | 3 | 0.333 | 0.000 | Down | 0.191 | 0.234 | 0.152 | 0.180 |
| GO:0009186 | 4 | 0.250 | 0.250 | Up | 0.192 | 0.235 | 0.019 | 0.036 |
| GO:0006595 | 4 | 0.250 | 0.250 | Down | 0.197 | 0.240 | 0.041 | 0.060 |
| GO:0006221 | 7 | 0.286 | 0.143 | Down | 0.199 | 0.243 | 0.028 | 0.047 |
| GO:0006402 | 7 | 0.143 | 0.000 | Down | 0.200 | 0.244 | 0.237 | 0.267 |
| GO:0046039 | 18 | 0.167 | 0.222 | Down | 0.202 | 0.246 | 0.008 | 0.020 |
| GO:0044417 | 4 | 0.000 | 0.250 | Up | 0.202 | 0.246 | 0.119 | 0.144 |
| GO:0031334 | 2 | 0.000 | 0.000 | Down | 0.207 | 0.252 | 0.366 | 0.395 |
| GO:0042274 | 9 | 0.222 | 0.222 | Down | 0.209 | 0.253 | 0.023 | 0.041 |
| GO:0044053 | 4 | 0.000 | 0.250 | Up | 0.209 | 0.253 | 0.124 | 0.148 |
| GO:0051836 | 4 | 0.000 | 0.250 | Up | 0.209 | 0.253 | 0.118 | 0.143 |
| GO:0042000 | 4 | 0.000 | 0.250 | Up | 0.209 | 0.253 | 0.117 | 0.142 |
| GO:0010638 | 2 | 0.000 | 0.000 | Down | 0.210 | 0.253 | 0.372 | 0.400 |
| GO:0051808 | 4 | 0.000 | 0.250 | Up | 0.212 | 0.254 | 0.118 | 0.142 |
| GO:0035556 | 36 | 0.167 | 0.111 | Down | 0.212 | 0.254 | 0.034 | 0.053 |
| GO:0006855 | 3 | 0.000 | 0.000 | Up | 0.212 | 0.254 | 0.218 | 0.248 |
| GO:0051495 | 2 | 0.000 | 0.000 | Down | 0.212 | 0.254 | 0.373 | 0.401 |
| GO:0072330 | 21 | 0.095 | 0.143 | Up | 0.212 | 0.254 | 0.288 | 0.318 |
| GO:0030838 | 2 | 0.000 | 0.000 | Down | 0.212 | 0.254 | 0.369 | 0.397 |
| GO:1902579 | 4 | 0.000 | 0.250 | Up | 0.215 | 0.256 | 0.121 | 0.145 |
| GO:0015931 | 11 | 0.182 | 0.182 | Down | 0.215 | 0.256 | 0.054 | 0.074 |
| GO:0045010 | 2 | 0.000 | 0.000 | Down | 0.216 | 0.258 | 0.371 | 0.399 |
| GO:0044766 | 4 | 0.000 | 0.250 | Up | 0.216 | 0.258 | 0.125 | 0.149 |
| GO:0032273 | 2 | 0.000 | 0.000 | Down | 0.217 | 0.259 | 0.379 | 0.407 |
| GO:0009166 | 19 | 0.158 | 0.158 | Down | 0.219 | 0.260 | 0.039 | 0.058 |
| GO:0015893 | 3 | 0.000 | 0.000 | Up | 0.221 | 0.262 | 0.223 | 0.252 |
| GO:0071897 | 1 | 0.000 | 0.000 | Up | 0.223 | 0.264 | 0.223 | 0.252 |
| GO:0015858 | 3 | 0.000 | 0.333 | Up | 0.226 | 0.267 | 0.202 | 0.233 |
| GO:0006633 | 19 | 0.105 | 0.158 | Up | 0.229 | 0.271 | 0.240 | 0.270 |
| GO:0009143 | 18 | 0.167 | 0.167 | Down | 0.232 | 0.275 | 0.035 | 0.054 |
| GO:0006333 | 12 | 0.250 | 0.250 | Down | 0.236 | 0.279 | 0.049 | 0.069 |
| GO:0030261 | 2 | 0.000 | 0.000 | Down | 0.237 | 0.279 | 0.360 | 0.390 |
| GO:0006914 | 6 | 0.333 | 0.000 | Down | 0.238 | 0.280 | 0.203 | 0.234 |
| GO:0009126 | 17 | 0.118 | 0.294 | Up | 0.239 | 0.281 | 0.089 | 0.111 |
| GO:0009167 | 17 | 0.118 | 0.294 | Up | 0.239 | 0.281 | 0.092 | 0.114 |
| GO:0006405 | 4 | 0.250 | 0.250 | Down | 0.241 | 0.283 | 0.053 | 0.073 |
| GO:0009064 | 9 | 0.111 | 0.111 | Down | 0.250 | 0.293 | 0.078 | 0.099 |
| GO:0006512 | 5 | 0.400 | 0.000 | Down | 0.255 | 0.298 | 0.099 | 0.121 |
| GO:0046434 | 22 | 0.182 | 0.136 | Down | 0.259 | 0.303 | 0.041 | 0.060 |
| GO:0051247 | 3 | 0.333 | 0.333 | Up | 0.260 | 0.303 | 0.038 | 0.057 |
| GO:0015849 | 13 | 0.154 | 0.077 | Down | 0.260 | 0.303 | 0.094 | 0.117 |
| GO:0032270 | 3 | 0.333 | 0.333 | Up | 0.262 | 0.305 | 0.035 | 0.054 |
| GO:0007034 | 5 | 0.200 | 0.200 | Down | 0.263 | 0.306 | 0.042 | 0.061 |
| GO:0052652 | 2 | 0.500 | 0.000 | Down | 0.264 | 0.306 | 0.115 | 0.139 |
| GO:0046068 | 2 | 0.500 | 0.000 | Down | 0.268 | 0.311 | 0.114 | 0.138 |
| GO:0046394 | 39 | 0.128 | 0.179 | Up | 0.271 | 0.314 | 0.045 | 0.063 |
| GO:0009063 | 6 | 0.167 | 0.333 | Up | 0.271 | 0.314 | 0.172 | 0.202 |
| GO:0046942 | 13 | 0.154 | 0.077 | Down | 0.272 | 0.314 | 0.098 | 0.120 |
| GO:1901264 | 5 | 0.000 | 0.200 | Up | 0.274 | 0.316 | 0.300 | 0.330 |
| GO:0016053 | 39 | 0.128 | 0.179 | Up | 0.276 | 0.318 | 0.050 | 0.069 |
| GO:0000226 | 5 | 0.000 | 0.200 | Up | 0.278 | 0.320 | 0.387 | 0.414 |
| GO:1901606 | 6 | 0.167 | 0.333 | Up | 0.278 | 0.320 | 0.175 | 0.204 |
| GO:0044093 | 4 | 0.250 | 0.250 | Down | 0.280 | 0.322 | 0.064 | 0.085 |
| GO:0009123 | 18 | 0.111 | 0.278 | Up | 0.282 | 0.323 | 0.087 | 0.109 |
| GO:0019692 | 3 | 0.333 | 0.000 | Down | 0.282 | 0.323 | 0.118 | 0.143 |
| GO:0043952 | 5 | 0.200 | 0.200 | Down | 0.285 | 0.326 | 0.028 | 0.048 |
| GO:0009200 | 3 | 0.333 | 0.000 | Down | 0.286 | 0.327 | 0.121 | 0.145 |
| GO:0043085 | 4 | 0.250 | 0.250 | Down | 0.287 | 0.327 | 0.068 | 0.089 |
| GO:0009394 | 3 | 0.333 | 0.000 | Down | 0.287 | 0.327 | 0.123 | 0.147 |
| GO:0007264 | 24 | 0.167 | 0.125 | Down | 0.290 | 0.330 | 0.040 | 0.060 |
| GO:0006370 | 3 | 0.000 | 0.000 | Down | 0.292 | 0.332 | 0.304 | 0.334 |
| GO:0009069 | 7 | 0.000 | 0.286 | Up | 0.293 | 0.333 | 0.241 | 0.270 |
| GO:1901292 | 20 | 0.150 | 0.150 | Down | 0.294 | 0.334 | 0.054 | 0.074 |
| GO:0009161 | 18 | 0.111 | 0.278 | Up | 0.295 | 0.334 | 0.095 | 0.117 |
| GO:0040029 | 3 | 0.333 | 0.000 | Down | 0.303 | 0.343 | 0.283 | 0.314 |
| GO:0006429 | 2 | 0.500 | 0.000 | Down | 0.306 | 0.346 | 0.200 | 0.231 |
| GO:0006360 | 3 | 0.333 | 0.000 | Down | 0.307 | 0.347 | 0.088 | 0.110 |
| GO:0006720 | 7 | 0.143 | 0.143 | Down | 0.311 | 0.351 | 0.036 | 0.055 |
| GO:0007067 | 11 | 0.000 | 0.091 | Up | 0.311 | 0.351 | 0.529 | 0.550 |
| GO:0008299 | 7 | 0.143 | 0.143 | Down | 0.315 | 0.354 | 0.037 | 0.057 |
| GO:0016458 | 3 | 0.333 | 0.333 | Down | 0.315 | 0.355 | 0.041 | 0.060 |
| GO:0006040 | 4 | 0.250 | 0.250 | Up | 0.318 | 0.358 | 0.094 | 0.116 |
| GO:0016925 | 4 | 0.250 | 0.250 | Down | 0.322 | 0.362 | 0.046 | 0.065 |
| GO:0006269 | 2 | 0.000 | 0.500 | Up | 0.325 | 0.364 | 0.289 | 0.320 |
| GO:0006072 | 5 | 0.400 | 0.200 | Down | 0.327 | 0.366 | 0.110 | 0.135 |
| GO:0052646 | 6 | 0.333 | 0.333 | Up | 0.329 | 0.368 | 0.044 | 0.062 |
| GO:0007169 | 3 | 0.000 | 0.000 | Up | 0.344 | 0.384 | 0.487 | 0.512 |
| GO:0006302 | 5 | 0.000 | 0.200 | Up | 0.347 | 0.388 | 0.328 | 0.359 |
| GO:0007167 | 3 | 0.000 | 0.000 | Up | 0.351 | 0.391 | 0.488 | 0.512 |
| GO:1901071 | 3 | 0.333 | 0.333 | Down | 0.355 | 0.395 | 0.127 | 0.152 |
| GO:0009190 | 3 | 0.333 | 0.000 | Down | 0.355 | 0.395 | 0.237 | 0.267 |
| GO:0051168 | 8 | 0.125 | 0.125 | Down | 0.364 | 0.404 | 0.230 | 0.260 |
| GO:0000027 | 8 | 0.125 | 0.000 | Down | 0.365 | 0.405 | 0.292 | 0.322 |
| GO:0006119 | 3 | 0.333 | 0.333 | Down | 0.372 | 0.412 | 0.130 | 0.155 |
| GO:0002377 | 3 | 0.000 | 0.000 | Up | 0.377 | 0.417 | 0.212 | 0.242 |
| GO:0002440 | 3 | 0.000 | 0.000 | Up | 0.377 | 0.417 | 0.209 | 0.240 |
| GO:0070925 | 15 | 0.133 | 0.067 | Down | 0.380 | 0.419 | 0.293 | 0.323 |
| GO:0042773 | 3 | 0.333 | 0.333 | Down | 0.381 | 0.420 | 0.128 | 0.152 |
| GO:0009070 | 2 | 0.000 | 0.500 | Up | 0.382 | 0.421 | 0.222 | 0.252 |
| GO:0009187 | 4 | 0.250 | 0.000 | Down | 0.390 | 0.429 | 0.380 | 0.408 |
| GO:0008645 | 2 | 0.000 | 0.000 | Up | 0.391 | 0.430 | 0.505 | 0.530 |
| GO:0015749 | 2 | 0.000 | 0.000 | Up | 0.394 | 0.432 | 0.513 | 0.537 |
| GO:0006268 | 2 | 0.500 | 0.000 | Down | 0.395 | 0.433 | 0.339 | 0.368 |
| GO:0006270 | 11 | 0.091 | 0.182 | Up | 0.396 | 0.434 | 0.186 | 0.216 |
| GO:0009066 | 4 | 0.250 | 0.000 | Down | 0.397 | 0.435 | 0.664 | 0.676 |
| GO:0009084 | 3 | 0.000 | 0.000 | Down | 0.399 | 0.436 | 0.527 | 0.549 |
| GO:0006611 | 3 | 0.000 | 0.333 | Up | 0.412 | 0.450 | 0.183 | 0.213 |
| GO:0006122 | 2 | 0.000 | 0.500 | Up | 0.413 | 0.451 | 0.352 | 0.381 |
| GO:0042775 | 2 | 0.000 | 0.500 | Up | 0.417 | 0.454 | 0.351 | 0.381 |
| GO:0006614 | 5 | 0.200 | 0.200 | Down | 0.433 | 0.471 | 0.093 | 0.115 |
| GO:0006613 | 5 | 0.200 | 0.200 | Down | 0.436 | 0.474 | 0.095 | 0.117 |
| GO:0030048 | 4 | 0.250 | 0.250 | Up | 0.437 | 0.474 | 0.086 | 0.108 |
| GO:0050793 | 4 | 0.000 | 0.250 | Up | 0.438 | 0.475 | 0.279 | 0.310 |
| GO:0046777 | 1 | 0.000 | 0.000 | Up | 0.440 | 0.476 | 0.440 | 0.465 |
| GO:0000302 | 3 | 0.000 | 0.000 | Up | 0.440 | 0.476 | 0.527 | 0.549 |
| GO:1901700 | 3 | 0.000 | 0.000 | Up | 0.441 | 0.477 | 0.528 | 0.549 |
| GO:0006546 | 3 | 0.000 | 0.333 | Up | 0.444 | 0.479 | 0.392 | 0.419 |
| GO:0010035 | 3 | 0.000 | 0.000 | Up | 0.445 | 0.479 | 0.526 | 0.549 |
| GO:0009234 | 2 | 0.000 | 0.000 | Up | 0.445 | 0.479 | 0.421 | 0.447 |
| GO:0007033 | 4 | 0.250 | 0.000 | Down | 0.445 | 0.479 | 0.127 | 0.151 |
| GO:0006541 | 2 | 0.000 | 0.000 | Down | 0.446 | 0.479 | 0.422 | 0.447 |
| GO:0009233 | 2 | 0.000 | 0.000 | Up | 0.449 | 0.482 | 0.428 | 0.453 |
| GO:0006888 | 20 | 0.150 | 0.150 | Down | 0.450 | 0.482 | 0.074 | 0.095 |
| GO:0009071 | 3 | 0.000 | 0.333 | Up | 0.453 | 0.485 | 0.395 | 0.421 |
| GO:0006424 | 3 | 0.000 | 0.000 | Up | 0.459 | 0.491 | 0.271 | 0.302 |
| GO:0009219 | 2 | 0.000 | 0.000 | Up | 0.462 | 0.494 | 0.464 | 0.490 |
| GO:0006787 | 2 | 0.000 | 0.000 | Down | 0.467 | 0.498 | 0.506 | 0.530 |
| GO:0097428 | 1 | 0.000 | 0.000 | Down | 0.469 | 0.500 | 0.469 | 0.494 |
| GO:0048856 | 4 | 0.000 | 0.250 | Up | 0.476 | 0.507 | 0.366 | 0.395 |
| GO:0006885 | 8 | 0.125 | 0.125 | Down | 0.477 | 0.508 | 0.156 | 0.184 |
| GO:0033015 | 2 | 0.000 | 0.000 | Down | 0.478 | 0.508 | 0.516 | 0.539 |
| GO:0055067 | 8 | 0.125 | 0.125 | Down | 0.489 | 0.519 | 0.158 | 0.186 |
| GO:0016197 | 3 | 0.000 | 0.000 | Down | 0.497 | 0.527 | 0.403 | 0.428 |
| GO:0006891 | 3 | 0.000 | 0.000 | Up | 0.498 | 0.527 | 0.396 | 0.422 |
| GO:0042147 | 3 | 0.000 | 0.000 | Down | 0.504 | 0.534 | 0.401 | 0.427 |
| GO:0000280 | 14 | 0.071 | 0.071 | Up | 0.505 | 0.534 | 0.336 | 0.366 |
| GO:0048285 | 14 | 0.071 | 0.071 | Up | 0.514 | 0.543 | 0.341 | 0.370 |
| GO:0015908 | 3 | 0.333 | 0.000 | Up | 0.519 | 0.548 | 0.269 | 0.301 |
| GO:0000290 | 3 | 0.000 | 0.000 | Down | 0.534 | 0.563 | 0.644 | 0.661 |
| GO:0000288 | 3 | 0.000 | 0.000 | Down | 0.535 | 0.563 | 0.648 | 0.663 |
| GO:0006308 | 4 | 0.250 | 0.000 | Up | 0.551 | 0.579 | 0.177 | 0.206 |
| GO:0000724 | 2 | 0.000 | 0.000 | Down | 0.565 | 0.593 | 0.540 | 0.559 |
| GO:0000725 | 2 | 0.000 | 0.000 | Down | 0.571 | 0.599 | 0.543 | 0.561 |
| GO:0042255 | 11 | 0.091 | 0.091 | Down | 0.580 | 0.608 | 0.327 | 0.358 |
| GO:0008283 | 3 | 0.000 | 0.000 | Up | 0.581 | 0.609 | 0.472 | 0.497 |
| GO:0000070 | 2 | 0.000 | 0.000 | Down | 0.599 | 0.626 | 0.790 | 0.799 |
| GO:0000387 | 4 | 0.250 | 0.000 | Down | 0.600 | 0.627 | 0.600 | 0.618 |
| GO:0000819 | 2 | 0.000 | 0.000 | Down | 0.618 | 0.644 | 0.804 | 0.811 |
| GO:0022603 | 2 | 0.000 | 0.000 | Up | 0.619 | 0.645 | 0.395 | 0.421 |
| GO:0051452 | 7 | 0.000 | 0.143 | Up | 0.645 | 0.671 | 0.324 | 0.356 |
| GO:0045851 | 7 | 0.000 | 0.143 | Up | 0.647 | 0.672 | 0.325 | 0.356 |
| GO:0030641 | 7 | 0.000 | 0.143 | Up | 0.650 | 0.675 | 0.332 | 0.362 |
| GO:0030004 | 7 | 0.000 | 0.143 | Up | 0.650 | 0.675 | 0.330 | 0.361 |
| GO:0051453 | 7 | 0.000 | 0.143 | Up | 0.653 | 0.677 | 0.336 | 0.366 |
| GO:0007035 | 7 | 0.000 | 0.143 | Up | 0.655 | 0.679 | 0.327 | 0.358 |
| GO:0022900 | 7 | 0.143 | 0.143 | Up | 0.680 | 0.703 | 0.388 | 0.415 |
| GO:0022904 | 6 | 0.167 | 0.167 | Up | 0.682 | 0.704 | 0.279 | 0.310 |
| GO:0006865 | 4 | 0.000 | 0.000 | Up | 0.682 | 0.704 | 0.648 | 0.663 |
| GO:0009225 | 4 | 0.000 | 0.000 | Up | 0.693 | 0.714 | 0.449 | 0.474 |
| GO:0034637 | 3 | 0.000 | 0.000 | Down | 0.705 | 0.724 | 0.605 | 0.622 |
| GO:0019673 | 3 | 0.000 | 0.000 | Down | 0.705 | 0.724 | 0.606 | 0.622 |
| GO:0016114 | 2 | 0.000 | 0.000 | Down | 0.706 | 0.724 | 0.645 | 0.662 |
| GO:0000304 | 2 | 0.000 | 0.000 | Up | 0.706 | 0.724 | 0.651 | 0.665 |
| GO:0009072 | 3 | 0.000 | 0.000 | Up | 0.707 | 0.724 | 0.802 | 0.810 |
| GO:0009073 | 3 | 0.000 | 0.000 | Up | 0.707 | 0.724 | 0.803 | 0.811 |
| GO:0006721 | 2 | 0.000 | 0.000 | Down | 0.713 | 0.729 | 0.649 | 0.663 |
| GO:0006836 | 1 | 0.000 | 0.000 | Down | 0.718 | 0.734 | 0.662 | 0.676 |
| GO:0051187 | 3 | 0.000 | 0.000 | Down | 0.737 | 0.753 | 0.478 | 0.503 |
| GO:0051170 | 10 | 0.100 | 0.000 | Down | 0.745 | 0.760 | 0.542 | 0.561 |
| GO:0044744 | 10 | 0.100 | 0.000 | Down | 0.747 | 0.760 | 0.537 | 0.557 |
| GO:0034504 | 10 | 0.100 | 0.000 | Down | 0.747 | 0.760 | 0.543 | 0.561 |
| GO:1902593 | 10 | 0.100 | 0.000 | Down | 0.748 | 0.760 | 0.538 | 0.557 |
| GO:0006606 | 10 | 0.100 | 0.000 | Down | 0.749 | 0.761 | 0.545 | 0.562 |
| GO:0000096 | 3 | 0.000 | 0.000 | Down | 0.768 | 0.779 | 0.529 | 0.550 |
| GO:0060249 | 3 | 0.000 | 0.000 | Down | 0.791 | 0.802 | 0.830 | 0.836 |
| GO:0000723 | 3 | 0.000 | 0.000 | Down | 0.799 | 0.808 | 0.833 | 0.837 |
| GO:0032200 | 3 | 0.000 | 0.000 | Down | 0.800 | 0.808 | 0.833 | 0.837 |
| GO:0006471 | 3 | 0.000 | 0.000 | Up | 0.800 | 0.808 | 0.834 | 0.837 |
| GO:0031109 | 3 | 0.000 | 0.000 | Up | 0.803 | 0.809 | 0.711 | 0.721 |
| GO:0007020 | 3 | 0.000 | 0.000 | Up | 0.803 | 0.809 | 0.714 | 0.723 |
| GO:0046785 | 3 | 0.000 | 0.000 | Up | 0.807 | 0.813 | 0.715 | 0.723 |
| GO:0009067 | 3 | 0.000 | 0.000 | Down | 0.864 | 0.869 | 0.918 | 0.918 |
| GO:0042819 | 3 | 0.000 | 0.000 | Up | 0.877 | 0.881 | 0.696 | 0.708 |
| GO:0042816 | 3 | 0.000 | 0.000 | Up | 0.882 | 0.886 | 0.695 | 0.708 |
| GO:0008614 | 3 | 0.000 | 0.000 | Up | 0.883 | 0.886 | 0.698 | 0.709 |
| GO:0009432 | 2 | 0.000 | 0.000 | Down | 0.921 | 0.922 | 0.852 | 0.853 |
| GO:0072525 | 4 | 0.000 | 0.000 | Down | 0.921 | 0.922 | 0.834 | 0.837 |
| GO:0006607 | 3 | 0.000 | 0.000 | Down | 0.926 | 0.926 | 0.840 | 0.842 |
Also test using limma’s camera
kable(go_cam, digits = 3)
| NGenes | Correlation | Direction | PValue | FDR | |
|---|---|---|---|---|---|
| GO:0022610 | 113 | 0.087 | Down | 0.002 | 0.130 |
| GO:0020035 | 93 | 0.119 | Down | 0.002 | 0.130 |
| GO:0044406 | 93 | 0.119 | Down | 0.002 | 0.130 |
| GO:0009607 | 94 | 0.124 | Down | 0.003 | 0.130 |
| GO:0034118 | 87 | 0.131 | Down | 0.003 | 0.130 |
| GO:0020013 | 87 | 0.131 | Down | 0.003 | 0.130 |
| GO:0030155 | 87 | 0.131 | Down | 0.003 | 0.130 |
| GO:0034110 | 87 | 0.131 | Down | 0.003 | 0.130 |
| GO:0022407 | 87 | 0.131 | Down | 0.003 | 0.130 |
| GO:0051807 | 93 | 0.126 | Down | 0.003 | 0.130 |
| GO:0051834 | 93 | 0.126 | Down | 0.003 | 0.130 |
| GO:0051832 | 93 | 0.126 | Down | 0.003 | 0.130 |
| GO:0043207 | 93 | 0.126 | Down | 0.003 | 0.130 |
| GO:0051707 | 93 | 0.126 | Down | 0.003 | 0.130 |
| GO:0052173 | 93 | 0.126 | Down | 0.003 | 0.130 |
| GO:0052564 | 93 | 0.126 | Down | 0.003 | 0.130 |
| GO:0051805 | 93 | 0.126 | Down | 0.003 | 0.130 |
| GO:0051809 | 92 | 0.127 | Down | 0.003 | 0.130 |
| GO:0020033 | 92 | 0.127 | Down | 0.003 | 0.130 |
| GO:0044068 | 88 | 0.130 | Down | 0.003 | 0.130 |
| GO:0009605 | 100 | 0.116 | Down | 0.003 | 0.130 |
| GO:0044003 | 89 | 0.127 | Down | 0.003 | 0.130 |
| GO:0051817 | 89 | 0.127 | Down | 0.003 | 0.130 |
| GO:0035821 | 90 | 0.126 | Down | 0.004 | 0.143 |
| GO:0007155 | 69 | 0.181 | Down | 0.004 | 0.148 |
| GO:0016337 | 54 | 0.291 | Down | 0.005 | 0.185 |
| GO:0098602 | 54 | 0.291 | Down | 0.005 | 0.185 |
| GO:0065008 | 149 | 0.051 | Down | 0.007 | 0.254 |
| GO:0051704 | 189 | 0.053 | Down | 0.008 | 0.260 |
| GO:0044403 | 157 | 0.053 | Down | 0.009 | 0.265 |
| GO:0044419 | 157 | 0.053 | Down | 0.009 | 0.265 |
| GO:0009405 | 84 | 0.205 | Down | 0.010 | 0.290 |
| GO:0051701 | 147 | 0.054 | Down | 0.010 | 0.294 |
| GO:0009396 | 4 | -0.061 | Down | 0.013 | 0.360 |
| GO:0050896 | 291 | 0.030 | Down | 0.016 | 0.449 |
| GO:0016485 | 10 | 0.039 | Down | 0.020 | 0.544 |
| GO:0051604 | 12 | 0.024 | Down | 0.025 | 0.646 |
| GO:0050789 | 380 | 0.018 | Down | 0.025 | 0.646 |
| GO:0050794 | 359 | 0.017 | Down | 0.030 | 0.728 |
| GO:0031123 | 8 | 0.032 | Up | 0.030 | 0.728 |
| GO:0042026 | 3 | 0.098 | Down | 0.035 | 0.824 |
| GO:0006206 | 6 | -0.043 | Down | 0.036 | 0.824 |
| GO:0008154 | 1 | NA | Down | 0.044 | 0.907 |
| GO:0065007 | 401 | 0.019 | Down | 0.045 | 0.907 |
| GO:0001817 | 3 | 0.171 | Down | 0.048 | 0.907 |
| GO:0051239 | 3 | 0.171 | Down | 0.048 | 0.907 |
| GO:0031167 | 2 | 0.374 | Down | 0.052 | 0.907 |
| GO:0016255 | 4 | 0.220 | Up | 0.053 | 0.907 |
| GO:0006094 | 5 | 0.365 | Down | 0.061 | 0.907 |
| GO:0019319 | 6 | 0.310 | Down | 0.062 | 0.907 |
| GO:0046364 | 6 | 0.310 | Down | 0.062 | 0.907 |
| GO:0000245 | 9 | 0.064 | Down | 0.063 | 0.907 |
| GO:0002098 | 4 | 0.005 | Up | 0.064 | 0.907 |
| GO:0002097 | 4 | 0.005 | Up | 0.064 | 0.907 |
| GO:0031399 | 5 | 0.019 | Up | 0.064 | 0.907 |
| GO:0001932 | 5 | 0.019 | Up | 0.064 | 0.907 |
| GO:0042325 | 5 | 0.019 | Up | 0.064 | 0.907 |
| GO:0019856 | 5 | -0.092 | Down | 0.065 | 0.907 |
| GO:0006207 | 5 | -0.092 | Down | 0.065 | 0.907 |
| GO:0046112 | 5 | -0.092 | Down | 0.065 | 0.907 |
| GO:0051051 | 3 | 0.257 | Up | 0.067 | 0.907 |
| GO:0022616 | 5 | 0.065 | Up | 0.069 | 0.907 |
| GO:0006271 | 5 | 0.065 | Up | 0.069 | 0.907 |
| GO:0016571 | 5 | 0.090 | Down | 0.071 | 0.907 |
| GO:0090151 | 3 | -0.153 | Down | 0.077 | 0.907 |
| GO:0007007 | 3 | -0.153 | Down | 0.077 | 0.907 |
| GO:0045039 | 3 | -0.153 | Down | 0.077 | 0.907 |
| GO:0007006 | 3 | -0.153 | Down | 0.077 | 0.907 |
| GO:0006457 | 72 | 0.076 | Down | 0.077 | 0.907 |
| GO:0006813 | 4 | -0.030 | Up | 0.078 | 0.907 |
| GO:0006760 | 5 | -0.033 | Down | 0.079 | 0.907 |
| GO:0032507 | 2 | 0.148 | Up | 0.080 | 0.907 |
| GO:0051651 | 2 | 0.148 | Up | 0.080 | 0.907 |
| GO:0009112 | 7 | -0.036 | Down | 0.082 | 0.907 |
| GO:0032312 | 2 | 0.491 | Up | 0.083 | 0.907 |
| GO:0006465 | 7 | 0.040 | Down | 0.086 | 0.907 |
| GO:0006096 | 17 | 0.244 | Down | 0.086 | 0.907 |
| GO:0018394 | 4 | 0.031 | Up | 0.088 | 0.907 |
| GO:0006475 | 4 | 0.031 | Up | 0.088 | 0.907 |
| GO:0018393 | 4 | 0.031 | Up | 0.088 | 0.907 |
| GO:0016573 | 4 | 0.031 | Up | 0.088 | 0.907 |
| GO:0006848 | 2 | -0.122 | Down | 0.088 | 0.907 |
| GO:0000910 | 4 | 0.100 | Up | 0.092 | 0.907 |
| GO:0032501 | 8 | 0.040 | Up | 0.099 | 0.907 |
| GO:0044724 | 24 | 0.192 | Down | 0.100 | 0.907 |
| GO:0016052 | 24 | 0.192 | Down | 0.100 | 0.907 |
| GO:0071900 | 3 | 0.333 | Up | 0.100 | 0.907 |
| GO:0000079 | 3 | 0.333 | Up | 0.100 | 0.907 |
| GO:0043241 | 6 | -0.014 | Up | 0.102 | 0.907 |
| GO:0006338 | 4 | 0.002 | Down | 0.103 | 0.907 |
| GO:0043603 | 15 | -0.020 | Down | 0.105 | 0.907 |
| GO:0009247 | 12 | 0.076 | Up | 0.106 | 0.907 |
| GO:0046148 | 6 | 0.083 | Up | 0.109 | 0.907 |
| GO:0033014 | 6 | 0.083 | Up | 0.109 | 0.907 |
| GO:0006783 | 6 | 0.083 | Up | 0.109 | 0.907 |
| GO:0006779 | 6 | 0.083 | Up | 0.109 | 0.907 |
| GO:0046467 | 13 | 0.098 | Up | 0.111 | 0.907 |
| GO:0007275 | 6 | 0.258 | Up | 0.111 | 0.907 |
| GO:0035383 | 7 | 0.140 | Up | 0.112 | 0.907 |
| GO:0006637 | 7 | 0.140 | Up | 0.112 | 0.907 |
| GO:1901607 | 11 | 0.021 | Down | 0.113 | 0.907 |
| GO:0044707 | 7 | 0.145 | Up | 0.114 | 0.907 |
| GO:0016051 | 12 | 0.166 | Down | 0.114 | 0.907 |
| GO:0006497 | 18 | 0.106 | Up | 0.115 | 0.907 |
| GO:0042158 | 18 | 0.106 | Up | 0.115 | 0.907 |
| GO:0042157 | 18 | 0.106 | Up | 0.115 | 0.907 |
| GO:0006006 | 12 | 0.196 | Down | 0.116 | 0.907 |
| GO:0006643 | 15 | 0.102 | Up | 0.117 | 0.907 |
| GO:0006664 | 13 | 0.070 | Up | 0.119 | 0.907 |
| GO:0009206 | 8 | 0.117 | Up | 0.119 | 0.907 |
| GO:0009201 | 8 | 0.117 | Up | 0.119 | 0.907 |
| GO:0043543 | 15 | 0.052 | Up | 0.121 | 0.907 |
| GO:0043631 | 6 | 0.027 | Up | 0.122 | 0.907 |
| GO:0009152 | 17 | 0.035 | Up | 0.123 | 0.907 |
| GO:0042176 | 3 | 0.664 | Down | 0.123 | 0.907 |
| GO:0034968 | 4 | 0.016 | Down | 0.123 | 0.907 |
| GO:0006066 | 7 | 0.019 | Down | 0.124 | 0.907 |
| GO:0019318 | 14 | 0.184 | Down | 0.128 | 0.907 |
| GO:0005996 | 14 | 0.184 | Down | 0.128 | 0.907 |
| GO:0097354 | 6 | 0.029 | Up | 0.129 | 0.907 |
| GO:0018342 | 6 | 0.029 | Up | 0.129 | 0.907 |
| GO:0043648 | 10 | -0.011 | Down | 0.132 | 0.907 |
| GO:0051276 | 43 | 0.049 | Down | 0.132 | 0.907 |
| GO:0006410 | 5 | -0.053 | Up | 0.132 | 0.907 |
| GO:0006506 | 9 | 0.201 | Up | 0.133 | 0.907 |
| GO:0045859 | 4 | 0.091 | Up | 0.134 | 0.907 |
| GO:0051338 | 4 | 0.091 | Up | 0.134 | 0.907 |
| GO:0043549 | 4 | 0.091 | Up | 0.134 | 0.907 |
| GO:0032784 | 3 | 0.212 | Down | 0.135 | 0.907 |
| GO:0006518 | 11 | 0.002 | Down | 0.136 | 0.907 |
| GO:0044767 | 11 | 0.138 | Up | 0.136 | 0.907 |
| GO:0031338 | 14 | 0.037 | Up | 0.139 | 0.907 |
| GO:0006730 | 4 | 0.007 | Down | 0.141 | 0.907 |
| GO:0000154 | 5 | 0.080 | Down | 0.141 | 0.907 |
| GO:0007005 | 14 | 0.031 | Down | 0.141 | 0.907 |
| GO:0072655 | 14 | 0.031 | Down | 0.141 | 0.907 |
| GO:0070585 | 14 | 0.031 | Down | 0.141 | 0.907 |
| GO:0006626 | 14 | 0.031 | Down | 0.141 | 0.907 |
| GO:0071616 | 4 | 0.230 | Up | 0.143 | 0.907 |
| GO:0006085 | 4 | 0.230 | Up | 0.143 | 0.907 |
| GO:0006086 | 4 | 0.230 | Up | 0.143 | 0.907 |
| GO:0035384 | 4 | 0.230 | Up | 0.143 | 0.907 |
| GO:0051188 | 30 | 0.051 | Up | 0.146 | 0.907 |
| GO:0071976 | 4 | -0.116 | Up | 0.148 | 0.907 |
| GO:0006505 | 10 | 0.178 | Up | 0.151 | 0.907 |
| GO:0009260 | 18 | 0.030 | Up | 0.155 | 0.907 |
| GO:0070682 | 6 | 0.571 | Down | 0.157 | 0.907 |
| GO:0006661 | 10 | 0.165 | Up | 0.157 | 0.907 |
| GO:0032502 | 12 | 0.100 | Up | 0.157 | 0.907 |
| GO:1902580 | 33 | 0.013 | Down | 0.160 | 0.907 |
| GO:2000113 | 4 | 0.058 | Down | 0.160 | 0.907 |
| GO:0010558 | 4 | 0.058 | Down | 0.160 | 0.907 |
| GO:0045892 | 4 | 0.058 | Down | 0.160 | 0.907 |
| GO:1902679 | 4 | 0.058 | Down | 0.160 | 0.907 |
| GO:0051253 | 4 | 0.058 | Down | 0.160 | 0.907 |
| GO:0051172 | 4 | 0.058 | Down | 0.160 | 0.907 |
| GO:0045934 | 4 | 0.058 | Down | 0.160 | 0.907 |
| GO:0044743 | 6 | 0.093 | Down | 0.160 | 0.907 |
| GO:0051130 | 3 | -0.072 | Down | 0.162 | 0.907 |
| GO:0009147 | 3 | 0.062 | Up | 0.162 | 0.907 |
| GO:0070646 | 11 | -0.028 | Down | 0.163 | 0.907 |
| GO:0016579 | 11 | -0.028 | Down | 0.163 | 0.907 |
| GO:0046390 | 19 | 0.028 | Up | 0.164 | 0.907 |
| GO:0008535 | 1 | NA | Up | 0.166 | 0.907 |
| GO:0044272 | 14 | 0.044 | Up | 0.166 | 0.907 |
| GO:0035890 | 12 | 0.016 | Up | 0.168 | 0.907 |
| GO:0071826 | 31 | 0.050 | Down | 0.170 | 0.907 |
| GO:0018344 | 3 | 0.027 | Up | 0.170 | 0.907 |
| GO:0009890 | 5 | 0.108 | Down | 0.171 | 0.907 |
| GO:0031327 | 5 | 0.108 | Down | 0.171 | 0.907 |
| GO:0006473 | 6 | 0.100 | Up | 0.178 | 0.907 |
| GO:0006817 | 22 | 0.005 | Down | 0.179 | 0.907 |
| GO:0006084 | 5 | 0.297 | Up | 0.179 | 0.907 |
| GO:0006378 | 5 | 0.013 | Up | 0.180 | 0.907 |
| GO:0031124 | 5 | 0.013 | Up | 0.180 | 0.907 |
| GO:0071840 | 251 | 0.024 | Down | 0.180 | 0.907 |
| GO:0009628 | 22 | 0.051 | Down | 0.181 | 0.907 |
| GO:0043624 | 5 | -0.028 | Up | 0.186 | 0.907 |
| GO:0006415 | 5 | -0.028 | Up | 0.186 | 0.907 |
| GO:0072594 | 32 | 0.016 | Down | 0.186 | 0.907 |
| GO:0007015 | 4 | 0.045 | Down | 0.187 | 0.907 |
| GO:0006166 | 2 | 0.502 | Down | 0.188 | 0.907 |
| GO:0043101 | 2 | 0.502 | Down | 0.188 | 0.907 |
| GO:0043174 | 2 | 0.502 | Down | 0.188 | 0.907 |
| GO:0090150 | 11 | 0.019 | Down | 0.188 | 0.907 |
| GO:0072657 | 11 | 0.019 | Down | 0.188 | 0.907 |
| GO:0045017 | 17 | 0.061 | Up | 0.189 | 0.907 |
| GO:0010608 | 25 | 0.048 | Down | 0.190 | 0.907 |
| GO:0044723 | 42 | 0.139 | Down | 0.190 | 0.907 |
| GO:0030154 | 7 | 0.165 | Up | 0.191 | 0.907 |
| GO:0006754 | 7 | 0.084 | Up | 0.192 | 0.907 |
| GO:0015985 | 7 | 0.084 | Up | 0.192 | 0.907 |
| GO:0015986 | 7 | 0.084 | Up | 0.192 | 0.907 |
| GO:0006379 | 4 | 0.086 | Up | 0.192 | 0.907 |
| GO:0007049 | 36 | 0.021 | Up | 0.193 | 0.907 |
| GO:0043484 | 2 | -0.051 | Down | 0.195 | 0.907 |
| GO:0030029 | 10 | -0.036 | Down | 0.196 | 0.907 |
| GO:0006790 | 20 | 0.031 | Up | 0.197 | 0.907 |
| GO:0065002 | 11 | 0.031 | Down | 0.199 | 0.907 |
| GO:0006605 | 34 | 0.017 | Down | 0.199 | 0.907 |
| GO:0042777 | 1 | NA | Up | 0.199 | 0.907 |
| GO:0071806 | 16 | -0.005 | Down | 0.203 | 0.907 |
| GO:0018345 | 8 | 0.108 | Up | 0.203 | 0.907 |
| GO:0048518 | 11 | 0.080 | Down | 0.204 | 0.907 |
| GO:0043650 | 3 | -0.084 | Down | 0.205 | 0.907 |
| GO:0044712 | 59 | 0.070 | Down | 0.205 | 0.907 |
| GO:0035891 | 11 | 0.010 | Up | 0.208 | 0.907 |
| GO:0006098 | 9 | 0.150 | Down | 0.209 | 0.907 |
| GO:0046365 | 9 | 0.150 | Down | 0.209 | 0.907 |
| GO:0006740 | 9 | 0.150 | Down | 0.209 | 0.907 |
| GO:0006007 | 9 | 0.150 | Down | 0.209 | 0.907 |
| GO:0006739 | 9 | 0.150 | Down | 0.209 | 0.907 |
| GO:0019320 | 9 | 0.150 | Down | 0.209 | 0.907 |
| GO:0006325 | 29 | 0.035 | Down | 0.210 | 0.907 |
| GO:0006275 | 3 | -0.107 | Up | 0.210 | 0.907 |
| GO:0019362 | 10 | 0.132 | Down | 0.211 | 0.907 |
| GO:0046496 | 10 | 0.132 | Down | 0.211 | 0.907 |
| GO:0006081 | 6 | -0.065 | Up | 0.212 | 0.907 |
| GO:0006890 | 6 | 0.196 | Up | 0.216 | 0.907 |
| GO:0006420 | 3 | -0.196 | Up | 0.216 | 0.907 |
| GO:0046474 | 16 | 0.060 | Up | 0.216 | 0.907 |
| GO:0046165 | 6 | 0.032 | Down | 0.216 | 0.907 |
| GO:0022618 | 29 | 0.057 | Down | 0.217 | 0.907 |
| GO:0042594 | 3 | 0.308 | Down | 0.218 | 0.907 |
| GO:0032269 | 1 | NA | Up | 0.218 | 0.907 |
| GO:0051248 | 1 | NA | Up | 0.218 | 0.907 |
| GO:0000394 | 2 | 0.143 | Up | 0.221 | 0.907 |
| GO:0006388 | 2 | 0.143 | Up | 0.221 | 0.907 |
| GO:0016568 | 18 | 0.016 | Down | 0.221 | 0.907 |
| GO:0051235 | 3 | 0.041 | Up | 0.224 | 0.907 |
| GO:0045185 | 3 | 0.041 | Up | 0.224 | 0.907 |
| GO:0043094 | 3 | 0.233 | Down | 0.225 | 0.907 |
| GO:0006487 | 2 | -0.205 | Up | 0.226 | 0.907 |
| GO:0071496 | 5 | 0.043 | Down | 0.228 | 0.907 |
| GO:0031668 | 5 | 0.043 | Down | 0.228 | 0.907 |
| GO:0043933 | 107 | 0.033 | Down | 0.228 | 0.907 |
| GO:0006164 | 19 | 0.043 | Up | 0.228 | 0.907 |
| GO:0005975 | 53 | 0.109 | Down | 0.229 | 0.907 |
| GO:0044085 | 153 | 0.032 | Down | 0.229 | 0.907 |
| GO:0015698 | 23 | 0.000 | Down | 0.229 | 0.907 |
| GO:0006839 | 18 | 0.037 | Down | 0.231 | 0.907 |
| GO:0008033 | 37 | 0.035 | Up | 0.232 | 0.907 |
| GO:0034227 | 3 | -0.045 | Up | 0.234 | 0.907 |
| GO:0033013 | 8 | 0.053 | Up | 0.235 | 0.907 |
| GO:0042440 | 8 | 0.053 | Up | 0.235 | 0.907 |
| GO:0042168 | 8 | 0.053 | Up | 0.235 | 0.907 |
| GO:0006778 | 8 | 0.053 | Up | 0.235 | 0.907 |
| GO:0008616 | 4 | -0.058 | Down | 0.238 | 0.907 |
| GO:0046116 | 4 | -0.058 | Down | 0.238 | 0.907 |
| GO:0009266 | 21 | 0.061 | Down | 0.241 | 0.907 |
| GO:0034982 | 2 | 0.558 | Down | 0.242 | 0.907 |
| GO:0008380 | 81 | 0.072 | Down | 0.242 | 0.907 |
| GO:0022613 | 98 | 0.063 | Down | 0.242 | 0.907 |
| GO:0010629 | 6 | 0.071 | Down | 0.243 | 0.907 |
| GO:0007186 | 4 | -0.046 | Up | 0.245 | 0.907 |
| GO:0051301 | 23 | 0.063 | Up | 0.246 | 0.907 |
| GO:0072524 | 12 | 0.068 | Down | 0.246 | 0.907 |
| GO:0007059 | 8 | 0.098 | Up | 0.246 | 0.907 |
| GO:0010256 | 4 | 0.052 | Up | 0.246 | 0.907 |
| GO:0009060 | 17 | 0.093 | Up | 0.248 | 0.907 |
| GO:0006099 | 17 | 0.093 | Up | 0.248 | 0.907 |
| GO:0010564 | 17 | 0.015 | Up | 0.248 | 0.907 |
| GO:0015693 | 1 | NA | Up | 0.252 | 0.907 |
| GO:0009108 | 24 | 0.043 | Up | 0.253 | 0.907 |
| GO:0043248 | 8 | 0.181 | Down | 0.253 | 0.907 |
| GO:0009145 | 9 | 0.106 | Up | 0.255 | 0.907 |
| GO:0000375 | 64 | 0.094 | Down | 0.256 | 0.907 |
| GO:1901615 | 13 | 0.022 | Down | 0.257 | 0.907 |
| GO:0033365 | 33 | 0.014 | Down | 0.257 | 0.907 |
| GO:0009148 | 2 | 0.244 | Up | 0.258 | 0.907 |
| GO:0050658 | 7 | -0.027 | Down | 0.259 | 0.907 |
| GO:0051236 | 7 | -0.027 | Down | 0.259 | 0.907 |
| GO:0006403 | 7 | -0.027 | Down | 0.259 | 0.907 |
| GO:0050657 | 7 | -0.027 | Down | 0.259 | 0.907 |
| GO:0000278 | 13 | 0.089 | Up | 0.263 | 0.907 |
| GO:0016043 | 183 | 0.026 | Down | 0.264 | 0.907 |
| GO:0009452 | 6 | 0.107 | Down | 0.264 | 0.907 |
| GO:0036260 | 6 | 0.107 | Down | 0.264 | 0.907 |
| GO:0006417 | 22 | 0.051 | Down | 0.265 | 0.907 |
| GO:0006820 | 41 | 0.007 | Down | 0.265 | 0.907 |
| GO:0000003 | 3 | 0.081 | Down | 0.270 | 0.907 |
| GO:0048869 | 8 | 0.143 | Up | 0.270 | 0.907 |
| GO:0042493 | 51 | 0.049 | Down | 0.271 | 0.907 |
| GO:0031365 | 4 | 0.016 | Down | 0.274 | 0.907 |
| GO:0006414 | 20 | 0.086 | Down | 0.282 | 0.907 |
| GO:0033043 | 19 | 0.019 | Up | 0.284 | 0.907 |
| GO:0034622 | 64 | 0.044 | Down | 0.284 | 0.907 |
| GO:0015074 | 3 | 0.206 | Down | 0.285 | 0.907 |
| GO:0051258 | 8 | 0.081 | Up | 0.286 | 0.907 |
| GO:0000377 | 59 | 0.087 | Down | 0.287 | 0.907 |
| GO:0000398 | 59 | 0.087 | Down | 0.287 | 0.907 |
| GO:1903047 | 12 | 0.079 | Up | 0.287 | 0.907 |
| GO:0009408 | 20 | 0.059 | Down | 0.288 | 0.907 |
| GO:0006665 | 2 | 0.518 | Up | 0.289 | 0.907 |
| GO:1901137 | 55 | 0.043 | Up | 0.290 | 0.907 |
| GO:0006090 | 24 | 0.106 | Down | 0.290 | 0.907 |
| GO:0006875 | 4 | 0.294 | Up | 0.293 | 0.907 |
| GO:0055065 | 4 | 0.294 | Up | 0.293 | 0.907 |
| GO:0006996 | 110 | 0.025 | Down | 0.293 | 0.907 |
| GO:0044087 | 5 | -0.161 | Down | 0.296 | 0.907 |
| GO:0030833 | 5 | -0.161 | Down | 0.296 | 0.907 |
| GO:0032535 | 5 | -0.161 | Down | 0.296 | 0.907 |
| GO:0043254 | 5 | -0.161 | Down | 0.296 | 0.907 |
| GO:0090066 | 5 | -0.161 | Down | 0.296 | 0.907 |
| GO:0032271 | 5 | -0.161 | Down | 0.296 | 0.907 |
| GO:0032970 | 5 | -0.161 | Down | 0.296 | 0.907 |
| GO:0008064 | 5 | -0.161 | Down | 0.296 | 0.907 |
| GO:0032956 | 5 | -0.161 | Down | 0.296 | 0.907 |
| GO:0051493 | 5 | -0.161 | Down | 0.296 | 0.907 |
| GO:0030832 | 5 | -0.161 | Down | 0.296 | 0.907 |
| GO:0042439 | 4 | 0.067 | Down | 0.299 | 0.907 |
| GO:0046470 | 4 | 0.067 | Down | 0.299 | 0.907 |
| GO:0006656 | 4 | 0.067 | Down | 0.299 | 0.907 |
| GO:0042221 | 68 | 0.038 | Down | 0.299 | 0.907 |
| GO:0051260 | 3 | -0.165 | Down | 0.301 | 0.907 |
| GO:0006986 | 12 | 0.040 | Down | 0.301 | 0.907 |
| GO:0035966 | 12 | 0.040 | Down | 0.301 | 0.907 |
| GO:0008643 | 4 | 0.227 | Up | 0.302 | 0.907 |
| GO:0009142 | 10 | 0.118 | Up | 0.303 | 0.907 |
| GO:0046129 | 17 | 0.070 | Up | 0.305 | 0.907 |
| GO:0042451 | 17 | 0.070 | Up | 0.305 | 0.907 |
| GO:0019751 | 3 | 0.176 | Down | 0.307 | 0.907 |
| GO:0015914 | 4 | 0.039 | Down | 0.314 | 0.907 |
| GO:0006281 | 50 | 0.010 | Up | 0.316 | 0.907 |
| GO:0015980 | 24 | 0.079 | Up | 0.316 | 0.907 |
| GO:0010033 | 13 | 0.029 | Down | 0.318 | 0.907 |
| GO:0030036 | 8 | -0.074 | Down | 0.322 | 0.907 |
| GO:0009127 | 11 | 0.065 | Up | 0.322 | 0.907 |
| GO:0009168 | 11 | 0.065 | Up | 0.322 | 0.907 |
| GO:0015937 | 4 | 0.243 | Up | 0.323 | 0.907 |
| GO:0033866 | 4 | 0.243 | Up | 0.323 | 0.907 |
| GO:0034032 | 4 | 0.243 | Up | 0.323 | 0.907 |
| GO:0034033 | 4 | 0.243 | Up | 0.323 | 0.907 |
| GO:0033875 | 4 | 0.243 | Up | 0.323 | 0.907 |
| GO:0015936 | 4 | 0.243 | Up | 0.323 | 0.907 |
| GO:0033865 | 4 | 0.243 | Up | 0.323 | 0.907 |
| GO:0034030 | 4 | 0.243 | Up | 0.323 | 0.907 |
| GO:0009132 | 5 | 0.120 | Up | 0.326 | 0.907 |
| GO:0006357 | 10 | -0.030 | Down | 0.326 | 0.907 |
| GO:0000350 | 3 | -0.022 | Down | 0.327 | 0.907 |
| GO:0006750 | 3 | -0.117 | Up | 0.329 | 0.907 |
| GO:0019184 | 3 | -0.117 | Up | 0.329 | 0.907 |
| GO:0043043 | 3 | -0.117 | Up | 0.329 | 0.907 |
| GO:0046395 | 7 | -0.029 | Up | 0.330 | 0.907 |
| GO:0044282 | 7 | -0.029 | Up | 0.330 | 0.907 |
| GO:0016054 | 7 | -0.029 | Up | 0.330 | 0.907 |
| GO:0048523 | 10 | -0.001 | Down | 0.331 | 0.907 |
| GO:0045333 | 23 | 0.078 | Up | 0.331 | 0.907 |
| GO:0042181 | 6 | 0.158 | Up | 0.332 | 0.907 |
| GO:1901661 | 6 | 0.158 | Up | 0.332 | 0.907 |
| GO:0042180 | 6 | 0.158 | Up | 0.332 | 0.907 |
| GO:1901663 | 6 | 0.158 | Up | 0.332 | 0.907 |
| GO:0022402 | 21 | 0.031 | Up | 0.332 | 0.907 |
| GO:0001522 | 17 | 0.018 | Up | 0.342 | 0.921 |
| GO:0044106 | 8 | -0.018 | Down | 0.342 | 0.921 |
| GO:0009308 | 8 | -0.018 | Down | 0.342 | 0.921 |
| GO:0006576 | 8 | -0.018 | Down | 0.342 | 0.921 |
| GO:0065003 | 74 | 0.039 | Down | 0.344 | 0.921 |
| GO:0009066 | 4 | -0.132 | Down | 0.344 | 0.921 |
| GO:0032012 | 3 | 0.006 | Up | 0.345 | 0.921 |
| GO:0042273 | 16 | 0.061 | Down | 0.345 | 0.921 |
| GO:0042398 | 11 | 0.008 | Down | 0.351 | 0.921 |
| GO:0000956 | 5 | 0.153 | Down | 0.352 | 0.921 |
| GO:0042559 | 6 | 0.011 | Down | 0.356 | 0.921 |
| GO:1901605 | 24 | 0.022 | Down | 0.356 | 0.921 |
| GO:0010638 | 2 | -0.137 | Down | 0.356 | 0.921 |
| GO:0031334 | 2 | -0.137 | Down | 0.356 | 0.921 |
| GO:0051495 | 2 | -0.137 | Down | 0.356 | 0.921 |
| GO:0030838 | 2 | -0.137 | Down | 0.356 | 0.921 |
| GO:0032273 | 2 | -0.137 | Down | 0.356 | 0.921 |
| GO:0045010 | 2 | -0.137 | Down | 0.356 | 0.921 |
| GO:0032984 | 8 | -0.007 | Up | 0.356 | 0.921 |
| GO:0022411 | 8 | -0.007 | Up | 0.356 | 0.921 |
| GO:0008213 | 8 | -0.009 | Down | 0.361 | 0.928 |
| GO:0006479 | 8 | -0.009 | Down | 0.361 | 0.928 |
| GO:0009056 | 171 | 0.071 | Down | 0.362 | 0.928 |
| GO:0010468 | 116 | 0.014 | Down | 0.365 | 0.933 |
| GO:0006575 | 13 | 0.020 | Down | 0.369 | 0.933 |
| GO:0006118 | 4 | 0.091 | Up | 0.369 | 0.933 |
| GO:0006974 | 51 | 0.010 | Up | 0.371 | 0.933 |
| GO:0006260 | 47 | 0.038 | Up | 0.372 | 0.933 |
| GO:0006979 | 10 | 0.005 | Down | 0.373 | 0.933 |
| GO:1901575 | 165 | 0.076 | Down | 0.374 | 0.933 |
| GO:0009991 | 7 | 0.043 | Down | 0.374 | 0.933 |
| GO:0006631 | 29 | 0.019 | Up | 0.375 | 0.933 |
| GO:0042254 | 80 | 0.075 | Down | 0.375 | 0.933 |
| GO:0006367 | 8 | 0.107 | Up | 0.379 | 0.933 |
| GO:1901617 | 9 | 0.024 | Down | 0.380 | 0.933 |
| GO:0030488 | 4 | 0.089 | Up | 0.382 | 0.933 |
| GO:0031324 | 6 | 0.066 | Down | 0.384 | 0.933 |
| GO:0051246 | 31 | 0.063 | Down | 0.385 | 0.933 |
| GO:0000413 | 10 | 0.138 | Down | 0.388 | 0.933 |
| GO:0018208 | 10 | 0.138 | Down | 0.388 | 0.933 |
| GO:0006825 | 3 | 0.018 | Up | 0.389 | 0.933 |
| GO:0019220 | 27 | 0.032 | Up | 0.391 | 0.933 |
| GO:0051174 | 27 | 0.032 | Up | 0.391 | 0.933 |
| GO:0030001 | 16 | 0.039 | Up | 0.392 | 0.933 |
| GO:0022607 | 83 | 0.034 | Down | 0.394 | 0.933 |
| GO:0006544 | 4 | 0.044 | Up | 0.394 | 0.933 |
| GO:0070085 | 7 | 0.109 | Up | 0.394 | 0.933 |
| GO:0006486 | 7 | 0.109 | Up | 0.394 | 0.933 |
| GO:0009100 | 7 | 0.109 | Up | 0.394 | 0.933 |
| GO:0009101 | 7 | 0.109 | Up | 0.394 | 0.933 |
| GO:0043413 | 7 | 0.109 | Up | 0.394 | 0.933 |
| GO:0006265 | 3 | -0.090 | Down | 0.394 | 0.933 |
| GO:0016482 | 66 | 0.045 | Down | 0.395 | 0.933 |
| GO:0009124 | 12 | 0.048 | Up | 0.396 | 0.933 |
| GO:0009156 | 12 | 0.048 | Up | 0.396 | 0.933 |
| GO:0008610 | 53 | 0.039 | Up | 0.397 | 0.933 |
| GO:0006364 | 48 | 0.050 | Down | 0.399 | 0.933 |
| GO:0016072 | 48 | 0.050 | Down | 0.399 | 0.933 |
| GO:0006511 | 71 | 0.100 | Down | 0.400 | 0.933 |
| GO:0051128 | 22 | 0.017 | Up | 0.405 | 0.933 |
| GO:0030433 | 19 | 0.028 | Up | 0.408 | 0.933 |
| GO:0070647 | 29 | 0.040 | Down | 0.409 | 0.933 |
| GO:0009892 | 8 | 0.052 | Down | 0.409 | 0.933 |
| GO:0051186 | 45 | 0.040 | Up | 0.409 | 0.933 |
| GO:0002376 | 7 | 0.046 | Down | 0.409 | 0.933 |
| GO:1901264 | 5 | 0.250 | Up | 0.410 | 0.933 |
| GO:0060255 | 128 | 0.017 | Down | 0.411 | 0.933 |
| GO:0015858 | 3 | 0.390 | Up | 0.412 | 0.933 |
| GO:0006520 | 75 | 0.034 | Down | 0.413 | 0.933 |
| GO:0002682 | 6 | 0.158 | Down | 0.414 | 0.933 |
| GO:0050776 | 6 | 0.158 | Down | 0.414 | 0.933 |
| GO:0043086 | 3 | 0.068 | Down | 0.415 | 0.933 |
| GO:0044092 | 3 | 0.068 | Down | 0.415 | 0.933 |
| GO:0019752 | 129 | 0.031 | Down | 0.416 | 0.933 |
| GO:1901070 | 2 | 0.028 | Up | 0.417 | 0.933 |
| GO:0006897 | 7 | 0.015 | Down | 0.421 | 0.933 |
| GO:0030261 | 2 | 0.127 | Down | 0.425 | 0.933 |
| GO:0000226 | 5 | 0.096 | Up | 0.425 | 0.933 |
| GO:0009438 | 2 | -0.018 | Up | 0.426 | 0.933 |
| GO:0046131 | 2 | 0.111 | Up | 0.429 | 0.933 |
| GO:0009218 | 2 | 0.111 | Up | 0.429 | 0.933 |
| GO:0009220 | 2 | 0.111 | Up | 0.429 | 0.933 |
| GO:0046132 | 2 | 0.111 | Up | 0.429 | 0.933 |
| GO:0046134 | 2 | 0.111 | Up | 0.429 | 0.933 |
| GO:0006213 | 2 | 0.111 | Up | 0.429 | 0.933 |
| GO:0051049 | 27 | 0.063 | Up | 0.430 | 0.933 |
| GO:0032879 | 27 | 0.063 | Up | 0.430 | 0.933 |
| GO:0019941 | 73 | 0.100 | Down | 0.432 | 0.933 |
| GO:0043632 | 73 | 0.100 | Down | 0.432 | 0.933 |
| GO:0043436 | 130 | 0.031 | Down | 0.433 | 0.933 |
| GO:0006082 | 130 | 0.031 | Down | 0.433 | 0.933 |
| GO:0071103 | 19 | 0.080 | Down | 0.434 | 0.933 |
| GO:0006298 | 8 | -0.010 | Up | 0.436 | 0.933 |
| GO:0072330 | 21 | 0.041 | Up | 0.438 | 0.933 |
| GO:0071897 | 1 | NA | Up | 0.441 | 0.933 |
| GO:0051603 | 76 | 0.101 | Down | 0.443 | 0.933 |
| GO:0044257 | 76 | 0.101 | Down | 0.443 | 0.933 |
| GO:0030150 | 3 | 0.248 | Down | 0.450 | 0.933 |
| GO:0006743 | 5 | 0.225 | Up | 0.451 | 0.933 |
| GO:0006744 | 5 | 0.225 | Up | 0.451 | 0.933 |
| GO:0072522 | 22 | 0.056 | Up | 0.451 | 0.933 |
| GO:0046034 | 12 | 0.065 | Up | 0.455 | 0.933 |
| GO:0043087 | 18 | 0.026 | Up | 0.461 | 0.933 |
| GO:0033124 | 18 | 0.026 | Up | 0.461 | 0.933 |
| GO:0051028 | 4 | -0.095 | Down | 0.461 | 0.933 |
| GO:0006468 | 91 | 0.023 | Up | 0.462 | 0.933 |
| GO:0006402 | 7 | 0.067 | Down | 0.464 | 0.933 |
| GO:0006536 | 5 | -0.049 | Down | 0.466 | 0.933 |
| GO:0008654 | 25 | 0.054 | Up | 0.468 | 0.933 |
| GO:0010467 | 524 | 0.025 | Down | 0.469 | 0.933 |
| GO:0006826 | 3 | -0.097 | Down | 0.471 | 0.933 |
| GO:0015684 | 3 | -0.097 | Down | 0.471 | 0.933 |
| GO:0010605 | 7 | 0.037 | Down | 0.471 | 0.933 |
| GO:0007169 | 3 | -0.100 | Up | 0.473 | 0.933 |
| GO:0007167 | 3 | -0.100 | Up | 0.473 | 0.933 |
| GO:0016071 | 100 | 0.047 | Down | 0.475 | 0.933 |
| GO:0019222 | 152 | 0.017 | Down | 0.476 | 0.933 |
| GO:0009219 | 2 | -0.309 | Up | 0.477 | 0.933 |
| GO:0006629 | 86 | 0.026 | Up | 0.478 | 0.933 |
| GO:0006767 | 8 | 0.161 | Up | 0.480 | 0.933 |
| GO:0006766 | 8 | 0.161 | Up | 0.480 | 0.933 |
| GO:0042364 | 8 | 0.161 | Up | 0.480 | 0.933 |
| GO:0009110 | 8 | 0.161 | Up | 0.480 | 0.933 |
| GO:0006413 | 48 | 0.006 | Down | 0.483 | 0.933 |
| GO:0007067 | 11 | 0.140 | Up | 0.483 | 0.933 |
| GO:0051674 | 10 | 0.009 | Up | 0.486 | 0.933 |
| GO:0048870 | 10 | 0.009 | Up | 0.486 | 0.933 |
| GO:0071824 | 11 | 0.141 | Down | 0.486 | 0.933 |
| GO:0065004 | 11 | 0.141 | Down | 0.486 | 0.933 |
| GO:0009084 | 3 | 0.093 | Down | 0.487 | 0.933 |
| GO:0044699 | 809 | 0.021 | Down | 0.488 | 0.933 |
| GO:0006633 | 19 | 0.038 | Up | 0.488 | 0.933 |
| GO:0017038 | 19 | 0.000 | Down | 0.489 | 0.933 |
| GO:0006914 | 6 | -0.061 | Down | 0.489 | 0.933 |
| GO:0006873 | 11 | 0.128 | Up | 0.490 | 0.933 |
| GO:0030003 | 11 | 0.128 | Up | 0.490 | 0.933 |
| GO:0044262 | 11 | 0.123 | Down | 0.493 | 0.933 |
| GO:0006269 | 2 | 0.100 | Up | 0.493 | 0.933 |
| GO:0020027 | 7 | 0.159 | Up | 0.494 | 0.933 |
| GO:0042540 | 7 | 0.159 | Up | 0.494 | 0.933 |
| GO:0006434 | 3 | 0.129 | Down | 0.496 | 0.933 |
| GO:0008652 | 20 | 0.010 | Down | 0.503 | 0.933 |
| GO:0016226 | 4 | -0.007 | Up | 0.504 | 0.933 |
| GO:0031163 | 4 | -0.007 | Up | 0.504 | 0.933 |
| GO:0051169 | 25 | 0.063 | Down | 0.504 | 0.933 |
| GO:0006913 | 25 | 0.063 | Down | 0.504 | 0.933 |
| GO:0006401 | 10 | 0.119 | Down | 0.507 | 0.933 |
| GO:0009263 | 4 | 0.060 | Up | 0.511 | 0.933 |
| GO:0031326 | 111 | 0.013 | Down | 0.511 | 0.933 |
| GO:0009889 | 111 | 0.013 | Down | 0.511 | 0.933 |
| GO:0044265 | 97 | 0.090 | Down | 0.511 | 0.933 |
| GO:0032508 | 6 | 0.101 | Down | 0.513 | 0.933 |
| GO:0032392 | 6 | 0.101 | Down | 0.513 | 0.933 |
| GO:0006787 | 2 | -0.282 | Down | 0.515 | 0.933 |
| GO:0033015 | 2 | -0.282 | Down | 0.515 | 0.933 |
| GO:0051726 | 29 | 0.021 | Up | 0.516 | 0.933 |
| GO:0032318 | 15 | 0.019 | Up | 0.517 | 0.933 |
| GO:0033554 | 55 | 0.007 | Up | 0.518 | 0.933 |
| GO:1901700 | 3 | 0.176 | Up | 0.521 | 0.933 |
| GO:0010035 | 3 | 0.176 | Up | 0.521 | 0.933 |
| GO:0000302 | 3 | 0.176 | Up | 0.521 | 0.933 |
| GO:0009451 | 43 | 0.048 | Up | 0.522 | 0.933 |
| GO:0044255 | 73 | 0.026 | Up | 0.528 | 0.933 |
| GO:0006397 | 93 | 0.046 | Down | 0.528 | 0.933 |
| GO:0006091 | 41 | 0.088 | Down | 0.530 | 0.933 |
| GO:0006733 | 15 | 0.083 | Down | 0.530 | 0.933 |
| GO:0010556 | 110 | 0.012 | Down | 0.530 | 0.933 |
| GO:2000112 | 110 | 0.012 | Down | 0.530 | 0.933 |
| GO:0061024 | 17 | 0.014 | Down | 0.531 | 0.933 |
| GO:0043412 | 249 | 0.028 | Up | 0.532 | 0.933 |
| GO:0009057 | 101 | 0.085 | Down | 0.533 | 0.933 |
| GO:0006284 | 4 | 0.026 | Down | 0.534 | 0.933 |
| GO:0043604 | 5 | -0.080 | Up | 0.535 | 0.933 |
| GO:0015893 | 3 | -0.121 | Up | 0.538 | 0.933 |
| GO:0006855 | 3 | -0.121 | Up | 0.538 | 0.933 |
| GO:0015749 | 2 | 0.432 | Up | 0.541 | 0.933 |
| GO:0008645 | 2 | 0.432 | Up | 0.541 | 0.933 |
| GO:0044238 | 1268 | 0.022 | Down | 0.542 | 0.933 |
| GO:0040029 | 3 | -0.093 | Down | 0.543 | 0.933 |
| GO:0016310 | 99 | 0.023 | Up | 0.544 | 0.933 |
| GO:0018205 | 6 | -0.001 | Up | 0.544 | 0.933 |
| GO:0006400 | 19 | 0.061 | Up | 0.545 | 0.933 |
| GO:0044417 | 4 | 0.361 | Up | 0.547 | 0.933 |
| GO:0042000 | 4 | 0.361 | Up | 0.547 | 0.933 |
| GO:0051836 | 4 | 0.361 | Up | 0.547 | 0.933 |
| GO:0044766 | 4 | 0.361 | Up | 0.547 | 0.933 |
| GO:1902579 | 4 | 0.361 | Up | 0.547 | 0.933 |
| GO:0051808 | 4 | 0.361 | Up | 0.547 | 0.933 |
| GO:0044053 | 4 | 0.361 | Up | 0.547 | 0.933 |
| GO:0040011 | 58 | 0.048 | Up | 0.548 | 0.933 |
| GO:0044260 | 985 | 0.022 | Down | 0.548 | 0.933 |
| GO:0016042 | 5 | -0.029 | Up | 0.549 | 0.933 |
| GO:0006541 | 2 | -0.079 | Down | 0.550 | 0.933 |
| GO:0080090 | 141 | 0.015 | Down | 0.552 | 0.933 |
| GO:0000387 | 4 | -0.006 | Down | 0.557 | 0.933 |
| GO:0044248 | 137 | 0.072 | Down | 0.559 | 0.933 |
| GO:0044267 | 562 | 0.033 | Down | 0.560 | 0.933 |
| GO:0006732 | 37 | 0.033 | Up | 0.562 | 0.933 |
| GO:0090305 | 10 | 0.026 | Up | 0.562 | 0.933 |
| GO:0048522 | 8 | 0.064 | Down | 0.565 | 0.933 |
| GO:0030163 | 86 | 0.091 | Down | 0.565 | 0.933 |
| GO:0045047 | 7 | 0.038 | Down | 0.566 | 0.933 |
| GO:0072599 | 7 | 0.038 | Down | 0.566 | 0.933 |
| GO:0006612 | 7 | 0.038 | Down | 0.566 | 0.933 |
| GO:0006396 | 207 | 0.034 | Down | 0.566 | 0.933 |
| GO:0055082 | 12 | 0.110 | Up | 0.571 | 0.933 |
| GO:1901606 | 6 | -0.064 | Up | 0.572 | 0.933 |
| GO:0009063 | 6 | -0.064 | Up | 0.572 | 0.933 |
| GO:0031325 | 4 | 0.010 | Down | 0.572 | 0.933 |
| GO:0009893 | 4 | 0.010 | Down | 0.572 | 0.933 |
| GO:0010604 | 4 | 0.010 | Down | 0.572 | 0.933 |
| GO:0006268 | 2 | 0.218 | Down | 0.572 | 0.933 |
| GO:0051052 | 4 | -0.010 | Up | 0.575 | 0.933 |
| GO:0006370 | 3 | 0.073 | Down | 0.576 | 0.933 |
| GO:0044802 | 14 | 0.013 | Down | 0.576 | 0.933 |
| GO:0008295 | 3 | -0.086 | Up | 0.577 | 0.933 |
| GO:0042401 | 3 | -0.086 | Up | 0.577 | 0.933 |
| GO:0009309 | 3 | -0.086 | Up | 0.577 | 0.933 |
| GO:0006596 | 3 | -0.086 | Up | 0.577 | 0.933 |
| GO:0006261 | 27 | 0.042 | Up | 0.583 | 0.933 |
| GO:1901564 | 179 | 0.034 | Down | 0.583 | 0.933 |
| GO:0006366 | 21 | 0.080 | Up | 0.584 | 0.933 |
| GO:0006376 | 3 | 0.060 | Down | 0.584 | 0.933 |
| GO:0043170 | 1043 | 0.021 | Down | 0.584 | 0.933 |
| GO:0009069 | 7 | 0.031 | Up | 0.585 | 0.933 |
| GO:0044237 | 1238 | 0.022 | Down | 0.586 | 0.933 |
| GO:0050790 | 27 | 0.035 | Up | 0.587 | 0.933 |
| GO:0065009 | 27 | 0.035 | Up | 0.587 | 0.933 |
| GO:0042775 | 2 | 0.311 | Up | 0.591 | 0.933 |
| GO:0006122 | 2 | 0.311 | Up | 0.591 | 0.933 |
| GO:0007018 | 19 | 0.032 | Down | 0.592 | 0.933 |
| GO:0055076 | 3 | 0.178 | Up | 0.592 | 0.933 |
| GO:0046916 | 3 | 0.178 | Up | 0.592 | 0.933 |
| GO:0007166 | 8 | -0.035 | Up | 0.593 | 0.933 |
| GO:0006323 | 10 | 0.048 | Down | 0.594 | 0.933 |
| GO:0030522 | 2 | -0.191 | Down | 0.599 | 0.933 |
| GO:0009163 | 22 | 0.044 | Up | 0.599 | 0.933 |
| GO:0042455 | 22 | 0.044 | Up | 0.599 | 0.933 |
| GO:0015718 | 7 | -0.033 | Down | 0.599 | 0.933 |
| GO:0000290 | 3 | 0.026 | Down | 0.599 | 0.933 |
| GO:0000288 | 3 | 0.026 | Down | 0.599 | 0.933 |
| GO:0032787 | 53 | 0.032 | Down | 0.602 | 0.933 |
| GO:0043244 | 3 | -0.165 | Down | 0.604 | 0.933 |
| GO:1901565 | 31 | 0.037 | Down | 0.606 | 0.933 |
| GO:0009071 | 3 | -0.068 | Up | 0.606 | 0.933 |
| GO:0006546 | 3 | -0.068 | Up | 0.606 | 0.933 |
| GO:0031667 | 4 | 0.159 | Down | 0.608 | 0.933 |
| GO:0007010 | 21 | 0.008 | Up | 0.608 | 0.933 |
| GO:0017183 | 5 | 0.054 | Up | 0.610 | 0.933 |
| GO:0017182 | 5 | 0.054 | Up | 0.610 | 0.933 |
| GO:0033121 | 19 | 0.026 | Up | 0.610 | 0.933 |
| GO:0030811 | 19 | 0.026 | Up | 0.610 | 0.933 |
| GO:1900542 | 19 | 0.026 | Up | 0.610 | 0.933 |
| GO:0009118 | 19 | 0.026 | Up | 0.610 | 0.933 |
| GO:0006140 | 19 | 0.026 | Up | 0.610 | 0.933 |
| GO:0031329 | 19 | 0.026 | Up | 0.610 | 0.933 |
| GO:0019538 | 628 | 0.030 | Down | 0.611 | 0.933 |
| GO:0043161 | 21 | 0.036 | Up | 0.612 | 0.933 |
| GO:0010498 | 21 | 0.036 | Up | 0.612 | 0.933 |
| GO:0044281 | 231 | 0.036 | Down | 0.612 | 0.933 |
| GO:0070925 | 15 | 0.048 | Down | 0.613 | 0.933 |
| GO:0009987 | 1474 | 0.020 | Down | 0.613 | 0.933 |
| GO:0015672 | 24 | 0.045 | Up | 0.615 | 0.933 |
| GO:0030258 | 4 | -0.121 | Down | 0.615 | 0.933 |
| GO:0042558 | 7 | 0.005 | Down | 0.616 | 0.933 |
| GO:0006259 | 120 | 0.019 | Up | 0.617 | 0.933 |
| GO:0006512 | 5 | 0.079 | Down | 0.617 | 0.933 |
| GO:0006508 | 138 | 0.051 | Down | 0.617 | 0.933 |
| GO:0071704 | 1299 | 0.022 | Down | 0.617 | 0.933 |
| GO:0006352 | 14 | 0.065 | Up | 0.620 | 0.933 |
| GO:0010876 | 9 | -0.027 | Down | 0.621 | 0.933 |
| GO:0006869 | 9 | -0.027 | Down | 0.621 | 0.933 |
| GO:0052192 | 54 | 0.044 | Up | 0.622 | 0.933 |
| GO:0052126 | 54 | 0.044 | Up | 0.622 | 0.933 |
| GO:0048878 | 14 | 0.123 | Up | 0.622 | 0.933 |
| GO:0015748 | 6 | 0.082 | Down | 0.622 | 0.933 |
| GO:0006950 | 91 | 0.011 | Down | 0.623 | 0.933 |
| GO:0009233 | 2 | -0.158 | Up | 0.625 | 0.933 |
| GO:0009234 | 2 | -0.158 | Up | 0.625 | 0.933 |
| GO:0006302 | 5 | -0.041 | Up | 0.626 | 0.933 |
| GO:0051806 | 42 | 0.056 | Up | 0.629 | 0.933 |
| GO:0030260 | 42 | 0.056 | Up | 0.629 | 0.933 |
| GO:0009167 | 17 | 0.073 | Up | 0.630 | 0.933 |
| GO:0009126 | 17 | 0.073 | Up | 0.630 | 0.933 |
| GO:0042723 | 4 | 0.158 | Up | 0.631 | 0.933 |
| GO:0006772 | 4 | 0.158 | Up | 0.631 | 0.933 |
| GO:0042724 | 4 | 0.158 | Up | 0.631 | 0.933 |
| GO:0009228 | 4 | 0.158 | Up | 0.631 | 0.933 |
| GO:0033036 | 161 | 0.025 | Down | 0.631 | 0.933 |
| GO:0009262 | 7 | 0.011 | Up | 0.631 | 0.933 |
| GO:0046777 | 1 | NA | Up | 0.632 | 0.933 |
| GO:0006289 | 11 | 0.029 | Up | 0.632 | 0.933 |
| GO:0019439 | 37 | 0.087 | Down | 0.633 | 0.933 |
| GO:0000027 | 8 | 0.197 | Down | 0.635 | 0.933 |
| GO:0060627 | 23 | 0.065 | Up | 0.635 | 0.933 |
| GO:1901135 | 97 | 0.054 | Up | 0.636 | 0.933 |
| GO:0046700 | 39 | 0.080 | Down | 0.637 | 0.933 |
| GO:0044270 | 39 | 0.080 | Down | 0.637 | 0.933 |
| GO:1901361 | 39 | 0.080 | Down | 0.637 | 0.933 |
| GO:0043038 | 40 | 0.077 | Down | 0.637 | 0.933 |
| GO:0043039 | 40 | 0.077 | Down | 0.637 | 0.933 |
| GO:0036211 | 206 | 0.032 | Up | 0.638 | 0.933 |
| GO:0006464 | 206 | 0.032 | Up | 0.638 | 0.933 |
| GO:0098662 | 17 | 0.069 | Up | 0.638 | 0.933 |
| GO:0098655 | 17 | 0.069 | Up | 0.638 | 0.933 |
| GO:0098660 | 17 | 0.069 | Up | 0.638 | 0.933 |
| GO:0055086 | 85 | 0.056 | Down | 0.641 | 0.936 |
| GO:0016070 | 365 | 0.026 | Down | 0.642 | 0.936 |
| GO:0034641 | 602 | 0.019 | Down | 0.645 | 0.939 |
| GO:0006429 | 2 | 0.574 | Down | 0.648 | 0.942 |
| GO:0090407 | 64 | 0.045 | Up | 0.649 | 0.942 |
| GO:0015711 | 18 | 0.028 | Down | 0.650 | 0.942 |
| GO:0006812 | 42 | 0.028 | Up | 0.653 | 0.943 |
| GO:0032268 | 27 | 0.033 | Down | 0.656 | 0.943 |
| GO:0051252 | 87 | 0.015 | Down | 0.659 | 0.943 |
| GO:0009150 | 40 | 0.054 | Up | 0.661 | 0.943 |
| GO:0016311 | 15 | 0.038 | Down | 0.663 | 0.943 |
| GO:0034728 | 6 | 0.068 | Down | 0.663 | 0.943 |
| GO:0006334 | 6 | 0.068 | Down | 0.663 | 0.943 |
| GO:0034655 | 35 | 0.092 | Down | 0.670 | 0.943 |
| GO:0000819 | 2 | 0.198 | Down | 0.670 | 0.943 |
| GO:0000070 | 2 | 0.198 | Down | 0.670 | 0.943 |
| GO:0051716 | 109 | 0.014 | Up | 0.671 | 0.943 |
| GO:0006139 | 560 | 0.021 | Down | 0.673 | 0.943 |
| GO:0006807 | 627 | 0.019 | Down | 0.674 | 0.943 |
| GO:0008152 | 1383 | 0.022 | Down | 0.674 | 0.943 |
| GO:0097428 | 1 | NA | Down | 0.675 | 0.943 |
| GO:0016567 | 11 | 0.136 | Down | 0.676 | 0.943 |
| GO:0018202 | 6 | 0.020 | Up | 0.676 | 0.943 |
| GO:0009187 | 4 | 0.082 | Down | 0.677 | 0.943 |
| GO:0051259 | 6 | -0.037 | Up | 0.677 | 0.943 |
| GO:0072523 | 19 | 0.092 | Down | 0.680 | 0.943 |
| GO:0009164 | 19 | 0.092 | Down | 0.680 | 0.943 |
| GO:1901658 | 19 | 0.092 | Down | 0.680 | 0.943 |
| GO:0042454 | 19 | 0.092 | Down | 0.680 | 0.943 |
| GO:0006152 | 19 | 0.092 | Down | 0.680 | 0.943 |
| GO:0046130 | 19 | 0.092 | Down | 0.680 | 0.943 |
| GO:0050801 | 12 | 0.127 | Up | 0.684 | 0.943 |
| GO:0055080 | 12 | 0.127 | Up | 0.684 | 0.943 |
| GO:1901136 | 23 | 0.093 | Down | 0.684 | 0.943 |
| GO:0048193 | 26 | 0.113 | Up | 0.685 | 0.943 |
| GO:1901659 | 23 | 0.044 | Up | 0.687 | 0.943 |
| GO:0009064 | 9 | 0.038 | Down | 0.687 | 0.943 |
| GO:0006886 | 102 | 0.038 | Down | 0.691 | 0.943 |
| GO:0019693 | 42 | 0.047 | Up | 0.694 | 0.943 |
| GO:0048856 | 4 | 0.051 | Up | 0.696 | 0.943 |
| GO:0045184 | 143 | 0.030 | Down | 0.698 | 0.943 |
| GO:1902578 | 203 | 0.023 | Up | 0.698 | 0.943 |
| GO:0006412 | 231 | 0.049 | Down | 0.699 | 0.943 |
| GO:0009259 | 41 | 0.050 | Up | 0.699 | 0.943 |
| GO:0017004 | 2 | -0.476 | Up | 0.699 | 0.943 |
| GO:0009394 | 3 | -0.174 | Down | 0.699 | 0.943 |
| GO:0019692 | 3 | -0.174 | Down | 0.699 | 0.943 |
| GO:0009200 | 3 | -0.174 | Down | 0.699 | 0.943 |
| GO:1902600 | 16 | 0.077 | Up | 0.700 | 0.943 |
| GO:0051828 | 46 | 0.051 | Up | 0.701 | 0.943 |
| GO:0044409 | 46 | 0.051 | Up | 0.701 | 0.943 |
| GO:0090304 | 471 | 0.021 | Down | 0.702 | 0.943 |
| GO:0051649 | 138 | 0.031 | Down | 0.703 | 0.943 |
| GO:0031323 | 139 | 0.014 | Down | 0.703 | 0.943 |
| GO:0071705 | 16 | 0.025 | Down | 0.704 | 0.943 |
| GO:0009123 | 18 | 0.065 | Up | 0.705 | 0.943 |
| GO:0009161 | 18 | 0.065 | Up | 0.705 | 0.943 |
| GO:0009072 | 3 | -0.026 | Up | 0.707 | 0.943 |
| GO:0009073 | 3 | -0.026 | Up | 0.707 | 0.943 |
| GO:0000724 | 2 | -0.302 | Down | 0.707 | 0.943 |
| GO:0000725 | 2 | -0.302 | Down | 0.707 | 0.943 |
| GO:0032259 | 26 | 0.038 | Down | 0.708 | 0.943 |
| GO:0032446 | 18 | 0.084 | Down | 0.708 | 0.943 |
| GO:0009186 | 4 | 0.178 | Up | 0.711 | 0.943 |
| GO:0051336 | 21 | 0.038 | Up | 0.712 | 0.943 |
| GO:0055085 | 69 | 0.036 | Up | 0.712 | 0.943 |
| GO:0015031 | 142 | 0.031 | Down | 0.714 | 0.943 |
| GO:0016570 | 11 | 0.012 | Down | 0.714 | 0.943 |
| GO:0016569 | 11 | 0.012 | Down | 0.714 | 0.943 |
| GO:0008104 | 148 | 0.028 | Down | 0.715 | 0.943 |
| GO:0006220 | 8 | -0.050 | Up | 0.719 | 0.943 |
| GO:0006432 | 3 | -0.180 | Up | 0.720 | 0.943 |
| GO:0022406 | 4 | 0.070 | Down | 0.720 | 0.943 |
| GO:0048278 | 4 | 0.070 | Down | 0.720 | 0.943 |
| GO:0006904 | 4 | 0.070 | Down | 0.720 | 0.943 |
| GO:0009154 | 18 | 0.086 | Down | 0.723 | 0.943 |
| GO:0006195 | 18 | 0.086 | Down | 0.723 | 0.943 |
| GO:0009261 | 18 | 0.086 | Down | 0.723 | 0.943 |
| GO:0046483 | 584 | 0.020 | Down | 0.724 | 0.943 |
| GO:0006725 | 583 | 0.020 | Down | 0.726 | 0.943 |
| GO:0006270 | 11 | 0.076 | Up | 0.726 | 0.943 |
| GO:0000041 | 7 | 0.073 | Up | 0.729 | 0.943 |
| GO:0016192 | 83 | 0.048 | Up | 0.729 | 0.943 |
| GO:0009205 | 30 | 0.069 | Up | 0.730 | 0.943 |
| GO:0009199 | 30 | 0.069 | Up | 0.730 | 0.943 |
| GO:0009190 | 3 | 0.024 | Down | 0.731 | 0.943 |
| GO:1901360 | 587 | 0.020 | Down | 0.732 | 0.943 |
| GO:0009067 | 3 | -0.043 | Down | 0.733 | 0.943 |
| GO:0008283 | 3 | -0.043 | Up | 0.733 | 0.943 |
| GO:0044765 | 199 | 0.023 | Up | 0.734 | 0.943 |
| GO:0051168 | 8 | 0.039 | Down | 0.737 | 0.943 |
| GO:0002377 | 3 | 0.244 | Up | 0.739 | 0.943 |
| GO:0002440 | 3 | 0.244 | Up | 0.739 | 0.943 |
| GO:0000304 | 2 | 0.403 | Up | 0.740 | 0.943 |
| GO:0006383 | 7 | 0.013 | Down | 0.740 | 0.943 |
| GO:0015988 | 14 | 0.088 | Up | 0.741 | 0.943 |
| GO:0015991 | 14 | 0.088 | Up | 0.741 | 0.943 |
| GO:0034660 | 124 | 0.027 | Down | 0.741 | 0.943 |
| GO:0009070 | 2 | 0.280 | Up | 0.744 | 0.943 |
| GO:0070727 | 106 | 0.036 | Down | 0.746 | 0.943 |
| GO:0034613 | 106 | 0.036 | Down | 0.746 | 0.943 |
| GO:0048583 | 27 | 0.046 | Down | 0.746 | 0.943 |
| GO:0043414 | 18 | 0.015 | Down | 0.748 | 0.943 |
| GO:0046907 | 134 | 0.031 | Down | 0.749 | 0.943 |
| GO:0051641 | 142 | 0.030 | Down | 0.749 | 0.943 |
| GO:2001141 | 85 | 0.015 | Down | 0.752 | 0.943 |
| GO:0006355 | 85 | 0.015 | Down | 0.752 | 0.943 |
| GO:0044283 | 59 | 0.020 | Up | 0.755 | 0.943 |
| GO:1901069 | 17 | 0.078 | Down | 0.755 | 0.943 |
| GO:0006184 | 17 | 0.078 | Down | 0.755 | 0.943 |
| GO:0009146 | 17 | 0.078 | Down | 0.755 | 0.943 |
| GO:0009207 | 17 | 0.078 | Down | 0.755 | 0.943 |
| GO:0009203 | 17 | 0.078 | Down | 0.755 | 0.943 |
| GO:0006333 | 12 | 0.129 | Down | 0.760 | 0.947 |
| GO:0071702 | 174 | 0.026 | Down | 0.761 | 0.947 |
| GO:0006165 | 2 | -0.161 | Up | 0.762 | 0.947 |
| GO:0046939 | 2 | -0.161 | Up | 0.762 | 0.947 |
| GO:0048519 | 16 | 0.002 | Down | 0.766 | 0.950 |
| GO:0006470 | 11 | 0.055 | Up | 0.769 | 0.953 |
| GO:0006865 | 4 | 0.095 | Up | 0.773 | 0.954 |
| GO:0052652 | 2 | -0.286 | Down | 0.773 | 0.954 |
| GO:0046068 | 2 | -0.286 | Down | 0.773 | 0.954 |
| GO:0006418 | 38 | 0.080 | Down | 0.775 | 0.955 |
| GO:0006399 | 78 | 0.026 | Up | 0.776 | 0.955 |
| GO:0050793 | 4 | 0.138 | Up | 0.776 | 0.955 |
| GO:0009141 | 34 | 0.076 | Up | 0.778 | 0.955 |
| GO:0046486 | 25 | 0.011 | Up | 0.779 | 0.956 |
| GO:0045454 | 29 | 0.030 | Down | 0.783 | 0.957 |
| GO:0090501 | 4 | -0.046 | Down | 0.784 | 0.957 |
| GO:0006793 | 226 | 0.030 | Up | 0.785 | 0.957 |
| GO:0042147 | 3 | 0.024 | Down | 0.785 | 0.957 |
| GO:0016197 | 3 | 0.024 | Down | 0.785 | 0.957 |
| GO:0006072 | 5 | 0.123 | Down | 0.789 | 0.960 |
| GO:0009117 | 71 | 0.059 | Down | 0.790 | 0.960 |
| GO:0009166 | 19 | 0.097 | Down | 0.792 | 0.960 |
| GO:0060249 | 3 | 0.160 | Down | 0.795 | 0.960 |
| GO:0000723 | 3 | 0.160 | Down | 0.795 | 0.960 |
| GO:0032200 | 3 | 0.160 | Down | 0.795 | 0.960 |
| GO:0006891 | 3 | -0.084 | Up | 0.796 | 0.960 |
| GO:0048285 | 14 | 0.094 | Up | 0.797 | 0.960 |
| GO:0000280 | 14 | 0.094 | Up | 0.797 | 0.960 |
| GO:0009894 | 22 | 0.023 | Down | 0.798 | 0.960 |
| GO:1902589 | 44 | 0.028 | Down | 0.800 | 0.961 |
| GO:0006644 | 35 | 0.023 | Up | 0.806 | 0.967 |
| GO:0031497 | 7 | 0.054 | Down | 0.808 | 0.967 |
| GO:0015849 | 13 | 0.001 | Down | 0.809 | 0.967 |
| GO:0046942 | 13 | 0.001 | Down | 0.809 | 0.967 |
| GO:0006310 | 18 | -0.028 | Down | 0.810 | 0.967 |
| GO:0046785 | 3 | 0.152 | Up | 0.812 | 0.967 |
| GO:0031109 | 3 | 0.152 | Up | 0.812 | 0.967 |
| GO:0007020 | 3 | 0.152 | Up | 0.812 | 0.967 |
| GO:0042274 | 9 | 0.094 | Down | 0.814 | 0.967 |
| GO:1901566 | 80 | 0.036 | Up | 0.817 | 0.967 |
| GO:0046434 | 22 | 0.113 | Down | 0.818 | 0.967 |
| GO:0006351 | 81 | 0.026 | Down | 0.818 | 0.967 |
| GO:0006836 | 1 | NA | Down | 0.818 | 0.967 |
| GO:0044711 | 147 | 0.033 | Up | 0.819 | 0.967 |
| GO:0009143 | 18 | 0.098 | Down | 0.820 | 0.967 |
| GO:0006753 | 73 | 0.062 | Down | 0.821 | 0.967 |
| GO:0006446 | 9 | 0.069 | Up | 0.823 | 0.967 |
| GO:0016114 | 2 | 0.257 | Down | 0.826 | 0.967 |
| GO:0006721 | 2 | 0.257 | Down | 0.826 | 0.967 |
| GO:0006424 | 3 | 0.051 | Up | 0.826 | 0.967 |
| GO:0001510 | 9 | 0.043 | Up | 0.827 | 0.967 |
| GO:0006611 | 3 | 0.275 | Up | 0.827 | 0.967 |
| GO:0019673 | 3 | 0.232 | Down | 0.830 | 0.967 |
| GO:0015992 | 19 | 0.081 | Up | 0.830 | 0.967 |
| GO:0006818 | 19 | 0.081 | Up | 0.830 | 0.967 |
| GO:0006119 | 3 | -0.115 | Down | 0.831 | 0.967 |
| GO:0042773 | 3 | -0.115 | Down | 0.831 | 0.967 |
| GO:0046488 | 18 | 0.016 | Up | 0.833 | 0.968 |
| GO:0019637 | 115 | 0.050 | Down | 0.836 | 0.968 |
| GO:0044249 | 516 | 0.021 | Up | 0.837 | 0.968 |
| GO:0042255 | 11 | 0.072 | Down | 0.837 | 0.968 |
| GO:0032774 | 84 | 0.028 | Down | 0.838 | 0.968 |
| GO:0006040 | 4 | 0.057 | Up | 0.838 | 0.968 |
| GO:0006163 | 43 | 0.059 | Up | 0.841 | 0.970 |
| GO:0016925 | 4 | 0.106 | Down | 0.843 | 0.971 |
| GO:1901292 | 20 | 0.114 | Down | 0.845 | 0.972 |
| GO:0006360 | 3 | 0.190 | Down | 0.847 | 0.972 |
| GO:1901071 | 3 | 0.049 | Down | 0.848 | 0.972 |
| GO:0009144 | 31 | 0.073 | Up | 0.849 | 0.972 |
| GO:0046128 | 41 | 0.073 | Up | 0.851 | 0.972 |
| GO:0042278 | 41 | 0.073 | Up | 0.851 | 0.972 |
| GO:0044763 | 585 | 0.023 | Up | 0.853 | 0.972 |
| GO:0055067 | 8 | 0.183 | Down | 0.864 | 0.972 |
| GO:0006885 | 8 | 0.183 | Down | 0.864 | 0.972 |
| GO:0035556 | 36 | 0.034 | Down | 0.864 | 0.972 |
| GO:0007033 | 4 | 0.122 | Down | 0.865 | 0.972 |
| GO:0006471 | 3 | 0.143 | Up | 0.865 | 0.972 |
| GO:0055114 | 95 | 0.056 | Up | 0.865 | 0.972 |
| GO:0018193 | 25 | 0.040 | Up | 0.866 | 0.972 |
| GO:1901657 | 48 | 0.057 | Down | 0.866 | 0.972 |
| GO:1902582 | 80 | 0.029 | Down | 0.866 | 0.972 |
| GO:0034654 | 128 | 0.024 | Down | 0.869 | 0.972 |
| GO:0070271 | 42 | 0.055 | Down | 0.869 | 0.972 |
| GO:0006461 | 42 | 0.055 | Down | 0.869 | 0.972 |
| GO:0071822 | 51 | 0.038 | Down | 0.873 | 0.972 |
| GO:0022900 | 7 | 0.021 | Up | 0.874 | 0.972 |
| GO:1901293 | 37 | 0.051 | Up | 0.875 | 0.972 |
| GO:0007264 | 24 | 0.074 | Down | 0.876 | 0.972 |
| GO:0009058 | 529 | 0.022 | Up | 0.877 | 0.972 |
| GO:0072528 | 14 | 0.034 | Down | 0.877 | 0.972 |
| GO:0006928 | 33 | 0.010 | Down | 0.880 | 0.972 |
| GO:0007154 | 59 | 0.021 | Down | 0.882 | 0.972 |
| GO:0019725 | 42 | 0.044 | Up | 0.882 | 0.972 |
| GO:0051171 | 110 | 0.013 | Down | 0.886 | 0.972 |
| GO:0019219 | 110 | 0.013 | Down | 0.886 | 0.972 |
| GO:0045851 | 7 | 0.193 | Up | 0.887 | 0.972 |
| GO:0030641 | 7 | 0.193 | Up | 0.887 | 0.972 |
| GO:0051452 | 7 | 0.193 | Up | 0.887 | 0.972 |
| GO:0007035 | 7 | 0.193 | Up | 0.887 | 0.972 |
| GO:0051453 | 7 | 0.193 | Up | 0.887 | 0.972 |
| GO:0030004 | 7 | 0.193 | Up | 0.887 | 0.972 |
| GO:0009165 | 36 | 0.052 | Up | 0.888 | 0.972 |
| GO:0010639 | 3 | -0.208 | Down | 0.888 | 0.972 |
| GO:0051129 | 3 | -0.208 | Down | 0.888 | 0.972 |
| GO:0030837 | 3 | -0.208 | Down | 0.888 | 0.972 |
| GO:0051494 | 3 | -0.208 | Down | 0.888 | 0.972 |
| GO:0032272 | 3 | -0.208 | Down | 0.888 | 0.972 |
| GO:0031333 | 3 | -0.208 | Down | 0.888 | 0.972 |
| GO:0006650 | 24 | 0.010 | Up | 0.890 | 0.974 |
| GO:0043623 | 26 | 0.067 | Down | 0.891 | 0.974 |
| GO:0070972 | 8 | 0.007 | Down | 0.893 | 0.974 |
| GO:0051179 | 346 | 0.022 | Up | 0.894 | 0.974 |
| GO:0000393 | 5 | -0.050 | Down | 0.896 | 0.974 |
| GO:0006796 | 219 | 0.029 | Up | 0.896 | 0.974 |
| GO:0052646 | 6 | 0.105 | Up | 0.897 | 0.974 |
| GO:0009225 | 4 | 0.289 | Up | 0.901 | 0.974 |
| GO:0034637 | 3 | 0.216 | Down | 0.903 | 0.974 |
| GO:0023052 | 54 | 0.022 | Up | 0.904 | 0.974 |
| GO:0044700 | 54 | 0.022 | Up | 0.904 | 0.974 |
| GO:0007165 | 54 | 0.022 | Up | 0.904 | 0.974 |
| GO:0008216 | 4 | -0.019 | Down | 0.905 | 0.974 |
| GO:0006595 | 4 | -0.019 | Down | 0.905 | 0.974 |
| GO:0043085 | 4 | 0.072 | Down | 0.906 | 0.974 |
| GO:0044093 | 4 | 0.072 | Down | 0.906 | 0.974 |
| GO:0022603 | 2 | 0.407 | Up | 0.907 | 0.974 |
| GO:0009116 | 47 | 0.059 | Down | 0.909 | 0.975 |
| GO:0015908 | 3 | -0.064 | Up | 0.911 | 0.975 |
| GO:1901576 | 518 | 0.021 | Up | 0.911 | 0.975 |
| GO:0008299 | 7 | 0.180 | Down | 0.912 | 0.975 |
| GO:0006720 | 7 | 0.180 | Down | 0.912 | 0.975 |
| GO:0051187 | 3 | -0.184 | Down | 0.914 | 0.975 |
| GO:1901068 | 19 | 0.089 | Down | 0.915 | 0.975 |
| GO:0007017 | 31 | 0.014 | Up | 0.917 | 0.977 |
| GO:0034220 | 19 | 0.054 | Up | 0.918 | 0.977 |
| GO:0046578 | 17 | 0.024 | Down | 0.925 | 0.981 |
| GO:0051056 | 17 | 0.024 | Down | 0.925 | 0.981 |
| GO:1902531 | 17 | 0.024 | Down | 0.925 | 0.981 |
| GO:0042592 | 47 | 0.050 | Up | 0.927 | 0.982 |
| GO:0006810 | 332 | 0.022 | Up | 0.928 | 0.982 |
| GO:0006405 | 4 | -0.021 | Down | 0.929 | 0.982 |
| GO:0006749 | 4 | -0.192 | Up | 0.933 | 0.984 |
| GO:0046394 | 39 | 0.019 | Up | 0.935 | 0.984 |
| GO:0016053 | 39 | 0.019 | Up | 0.935 | 0.984 |
| GO:0044271 | 158 | 0.022 | Up | 0.936 | 0.984 |
| GO:0051234 | 333 | 0.022 | Up | 0.936 | 0.984 |
| GO:0006613 | 5 | 0.072 | Down | 0.941 | 0.987 |
| GO:0006614 | 5 | 0.072 | Down | 0.941 | 0.987 |
| GO:0006811 | 79 | 0.016 | Down | 0.947 | 0.987 |
| GO:0006606 | 10 | 0.072 | Down | 0.947 | 0.987 |
| GO:0051170 | 10 | 0.072 | Down | 0.947 | 0.987 |
| GO:0034504 | 10 | 0.072 | Down | 0.947 | 0.987 |
| GO:1902593 | 10 | 0.072 | Down | 0.947 | 0.987 |
| GO:0044744 | 10 | 0.072 | Down | 0.947 | 0.987 |
| GO:0032313 | 13 | 0.010 | Down | 0.949 | 0.987 |
| GO:0032483 | 13 | 0.010 | Down | 0.949 | 0.987 |
| GO:0015931 | 11 | -0.004 | Down | 0.957 | 0.990 |
| GO:0042819 | 3 | 0.426 | Up | 0.958 | 0.990 |
| GO:0042816 | 3 | 0.426 | Up | 0.958 | 0.990 |
| GO:0008614 | 3 | 0.426 | Up | 0.958 | 0.990 |
| GO:0022904 | 6 | 0.021 | Up | 0.959 | 0.990 |
| GO:0032270 | 3 | 0.033 | Up | 0.959 | 0.990 |
| GO:0051247 | 3 | 0.033 | Up | 0.959 | 0.990 |
| GO:0072525 | 4 | 0.278 | Down | 0.961 | 0.990 |
| GO:0034470 | 83 | 0.034 | Down | 0.965 | 0.990 |
| GO:0072521 | 48 | 0.067 | Up | 0.967 | 0.990 |
| GO:0044710 | 420 | 0.031 | Down | 0.967 | 0.990 |
| GO:0019438 | 148 | 0.021 | Up | 0.969 | 0.990 |
| GO:0030048 | 4 | -0.016 | Up | 0.969 | 0.990 |
| GO:0016458 | 3 | 0.047 | Down | 0.970 | 0.990 |
| GO:0009059 | 385 | 0.023 | Up | 0.971 | 0.990 |
| GO:0072511 | 6 | 0.042 | Down | 0.972 | 0.990 |
| GO:0070838 | 6 | 0.042 | Down | 0.972 | 0.990 |
| GO:0010646 | 21 | 0.044 | Up | 0.973 | 0.990 |
| GO:0023051 | 21 | 0.044 | Up | 0.973 | 0.990 |
| GO:0009966 | 21 | 0.044 | Up | 0.973 | 0.990 |
| GO:0034645 | 383 | 0.023 | Up | 0.974 | 0.990 |
| GO:0009119 | 46 | 0.058 | Down | 0.976 | 0.991 |
| GO:0006308 | 4 | 0.116 | Up | 0.979 | 0.993 |
| GO:0018130 | 152 | 0.021 | Down | 0.980 | 0.993 |
| GO:0072527 | 15 | 0.036 | Up | 0.981 | 0.993 |
| GO:0046039 | 18 | 0.083 | Down | 0.982 | 0.993 |
| GO:0007034 | 5 | -0.026 | Down | 0.993 | 0.999 |
| GO:0006607 | 3 | 0.251 | Down | 0.994 | 0.999 |
| GO:0046903 | 5 | 0.083 | Up | 0.994 | 0.999 |
| GO:0006887 | 5 | 0.083 | Up | 0.994 | 0.999 |
| GO:0032940 | 5 | 0.083 | Up | 0.994 | 0.999 |
| GO:0006888 | 20 | 0.145 | Up | 0.995 | 0.999 |
| GO:0043952 | 5 | 0.103 | Down | 0.995 | 0.999 |
| GO:0006221 | 7 | -0.052 | Up | 0.995 | 0.999 |
| GO:0009432 | 2 | 0.344 | Down | 0.998 | 0.999 |
| GO:0000096 | 3 | 0.136 | Up | 0.998 | 0.999 |
| GO:1901362 | 155 | 0.021 | Up | 0.999 | 0.999 |
Now KEGG pathway enrichment again making use of mroast and camera.
indices <- ids2indices(kegg.gene.sets, rownames(v2))
keg_mr <- mroast(v2, index = indices, design = modRUV, contrast = 2, nrot = 10000, set.statistic = "floormean")
keg_cam <- camera(v2, index = indices, design = modRUV, contrast = 2)
kable(keg_mr, digits = 3)
| NGenes | PropDown | PropUp | Direction | PValue | FDR | PValue.Mixed | FDR.Mixed | |
|---|---|---|---|---|---|---|---|---|
| ec00250__PK__KEGG | 12 | 0.250 | 0.000 | Down | 0.003 | 0.098 | 0.013 | 0.028 |
| ec00740__PK__KEGG | 8 | 0.375 | 0.500 | Up | 0.004 | 0.098 | 0.000 | 0.015 |
| ec00710__PK__KEGG | 10 | 0.600 | 0.000 | Down | 0.004 | 0.098 | 0.006 | 0.020 |
| ec00280__PK__KEGG | 8 | 0.125 | 0.500 | Up | 0.004 | 0.098 | 0.005 | 0.018 |
| ec00600__PK__KEGG | 11 | 0.091 | 0.545 | Up | 0.005 | 0.098 | 0.004 | 0.017 |
| ec00650__PK__KEGG | 18 | 0.056 | 0.444 | Up | 0.006 | 0.098 | 0.009 | 0.024 |
| ec00010__PK__KEGG | 25 | 0.440 | 0.080 | Down | 0.007 | 0.098 | 0.004 | 0.017 |
| ec00562__PK__KEGG | 18 | 0.278 | 0.111 | Down | 0.009 | 0.098 | 0.006 | 0.020 |
| ec00020__PK__KEGG | 18 | 0.111 | 0.389 | Up | 0.009 | 0.098 | 0.002 | 0.015 |
| ec00380__PK__KEGG | 61 | 0.180 | 0.246 | Up | 0.009 | 0.098 | 0.002 | 0.015 |
| ec00565__PK__KEGG | 24 | 0.208 | 0.292 | Up | 0.012 | 0.100 | 0.001 | 0.015 |
| ec00561__PK__KEGG | 15 | 0.133 | 0.200 | Up | 0.013 | 0.100 | 0.004 | 0.017 |
| ec00591__PK__KEGG | 7 | 0.286 | 0.143 | Down | 0.014 | 0.100 | 0.003 | 0.017 |
| ec00230__PK__KEGG | 78 | 0.244 | 0.128 | Down | 0.014 | 0.100 | 0.001 | 0.015 |
| ec00720__PK__KEGG | 17 | 0.118 | 0.412 | Up | 0.018 | 0.100 | 0.009 | 0.023 |
| ec00900__PK__KEGG | 26 | 0.077 | 0.269 | Up | 0.019 | 0.100 | 0.007 | 0.022 |
| ec00030__PK__KEGG | 14 | 0.429 | 0.000 | Down | 0.019 | 0.100 | 0.026 | 0.043 |
| ec00983__PK__KEGG | 15 | 0.400 | 0.067 | Down | 0.020 | 0.100 | 0.012 | 0.027 |
| ec00590__PK__KEGG | 7 | 0.286 | 0.000 | Down | 0.021 | 0.100 | 0.011 | 0.026 |
| ec00361__PK__KEGG | 6 | 0.167 | 0.500 | Up | 0.022 | 0.100 | 0.011 | 0.026 |
| ec00362__PK__KEGG | 19 | 0.158 | 0.368 | Up | 0.024 | 0.100 | 0.016 | 0.031 |
| ec00440__PK__KEGG | 4 | 0.500 | 0.000 | Down | 0.026 | 0.100 | 0.026 | 0.043 |
| ec00624__PK__KEGG | 36 | 0.222 | 0.222 | Up | 0.028 | 0.100 | 0.001 | 0.015 |
| ec00240__PK__KEGG | 72 | 0.194 | 0.167 | Up | 0.029 | 0.100 | 0.001 | 0.015 |
| ec00627__PK__KEGG | 61 | 0.213 | 0.246 | Up | 0.029 | 0.100 | 0.002 | 0.015 |
| ec00351__PK__KEGG | 1 | 0.000 | 1.000 | Up | 0.030 | 0.100 | 0.030 | 0.047 |
| ec00730__PK__KEGG | 14 | 0.071 | 0.214 | Up | 0.030 | 0.100 | 0.042 | 0.063 |
| ec00660__PK__KEGG | 3 | 0.000 | 0.667 | Up | 0.031 | 0.100 | 0.033 | 0.051 |
| ec00625__PK__KEGG | 4 | 0.250 | 0.250 | Down | 0.032 | 0.100 | 0.023 | 0.041 |
| ec00623__PK__KEGG | 17 | 0.118 | 0.353 | Up | 0.034 | 0.100 | 0.012 | 0.026 |
| ec00062__PK__KEGG | 6 | 0.167 | 0.667 | Up | 0.034 | 0.100 | 0.016 | 0.031 |
| ec00860__PK__KEGG | 50 | 0.160 | 0.200 | Up | 0.034 | 0.100 | 0.011 | 0.026 |
| ec00970__PK__KEGG | 41 | 0.341 | 0.171 | Down | 0.035 | 0.100 | 0.007 | 0.022 |
| ec00360__PK__KEGG | 49 | 0.204 | 0.245 | Up | 0.036 | 0.100 | 0.001 | 0.015 |
| ec00942__PK__KEGG | 46 | 0.174 | 0.261 | Up | 0.038 | 0.100 | 0.004 | 0.018 |
| ec00941__PK__KEGG | 36 | 0.222 | 0.222 | Up | 0.038 | 0.100 | 0.001 | 0.015 |
| ec00945__PK__KEGG | 36 | 0.222 | 0.222 | Up | 0.038 | 0.100 | 0.002 | 0.015 |
| ec00270__PK__KEGG | 49 | 0.224 | 0.204 | Up | 0.039 | 0.100 | 0.002 | 0.015 |
| ec01057__PK__KEGG | 42 | 0.190 | 0.238 | Up | 0.039 | 0.100 | 0.004 | 0.017 |
| ec00053__PK__KEGG | 7 | 0.143 | 0.286 | Up | 0.039 | 0.100 | 0.005 | 0.018 |
| ec01051__PK__KEGG | 36 | 0.222 | 0.222 | Up | 0.040 | 0.100 | 0.002 | 0.015 |
| ec00260__PK__KEGG | 16 | 0.062 | 0.438 | Up | 0.040 | 0.100 | 0.021 | 0.039 |
| ec00253__PK__KEGG | 51 | 0.176 | 0.235 | Up | 0.040 | 0.100 | 0.004 | 0.017 |
| ec00130__PK__KEGG | 40 | 0.225 | 0.200 | Up | 0.041 | 0.100 | 0.002 | 0.015 |
| ec00340__PK__KEGG | 46 | 0.196 | 0.239 | Up | 0.041 | 0.100 | 0.003 | 0.017 |
| ec00920__PK__KEGG | 4 | 0.000 | 0.500 | Up | 0.042 | 0.100 | 0.066 | 0.087 |
| ec00350__PK__KEGG | 50 | 0.200 | 0.220 | Up | 0.044 | 0.101 | 0.003 | 0.015 |
| ec00450__PK__KEGG | 41 | 0.195 | 0.220 | Up | 0.045 | 0.101 | 0.002 | 0.015 |
| ec00940__PK__KEGG | 48 | 0.188 | 0.229 | Up | 0.047 | 0.103 | 0.002 | 0.015 |
| ec00981__PK__KEGG | 38 | 0.184 | 0.237 | Up | 0.048 | 0.103 | 0.005 | 0.018 |
| ec00903__PK__KEGG | 16 | 0.188 | 0.312 | Up | 0.048 | 0.103 | 0.016 | 0.031 |
| ec00965__PK__KEGG | 12 | 0.083 | 0.417 | Up | 0.055 | 0.114 | 0.049 | 0.072 |
| ec00480__PK__KEGG | 25 | 0.200 | 0.280 | Up | 0.056 | 0.114 | 0.002 | 0.015 |
| ec00910__PK__KEGG | 6 | 0.167 | 0.000 | Down | 0.057 | 0.114 | 0.078 | 0.094 |
| ec00564__PK__KEGG | 53 | 0.151 | 0.264 | Up | 0.058 | 0.114 | 0.008 | 0.022 |
| ec00310__PK__KEGG | 40 | 0.225 | 0.275 | Up | 0.061 | 0.114 | 0.005 | 0.018 |
| ec00603__PK__KEGG | 1 | 0.000 | 1.000 | Up | 0.061 | 0.114 | 0.061 | 0.087 |
| ec00592__PK__KEGG | 9 | 0.222 | 0.222 | Down | 0.063 | 0.114 | 0.006 | 0.020 |
| ec00522__PK__KEGG | 1 | 0.000 | 1.000 | Up | 0.064 | 0.114 | 0.064 | 0.087 |
| ec00513__PK__KEGG | 1 | 0.000 | 1.000 | Up | 0.064 | 0.114 | 0.064 | 0.087 |
| ec00944__PK__KEGG | 1 | 0.000 | 1.000 | Up | 0.064 | 0.114 | 0.064 | 0.087 |
| ec00604__PK__KEGG | 1 | 0.000 | 1.000 | Up | 0.065 | 0.114 | 0.065 | 0.087 |
| ec00512__PK__KEGG | 1 | 0.000 | 1.000 | Up | 0.068 | 0.115 | 0.068 | 0.087 |
| ec00906__PK__KEGG | 13 | 0.154 | 0.385 | Up | 0.068 | 0.115 | 0.016 | 0.031 |
| ec00601__PK__KEGG | 1 | 0.000 | 1.000 | Up | 0.069 | 0.115 | 0.069 | 0.087 |
| ec00626__PK__KEGG | 13 | 0.154 | 0.308 | Up | 0.076 | 0.125 | 0.030 | 0.047 |
| ec00982__PK__KEGG | 3 | 0.333 | 0.333 | Down | 0.077 | 0.125 | 0.039 | 0.059 |
| ec00630__PK__KEGG | 9 | 0.111 | 0.444 | Up | 0.080 | 0.127 | 0.013 | 0.029 |
| ec00680__PK__KEGG | 24 | 0.208 | 0.292 | Up | 0.082 | 0.127 | 0.010 | 0.024 |
| ec00950__PK__KEGG | 48 | 0.167 | 0.229 | Up | 0.083 | 0.127 | 0.009 | 0.023 |
| ec00330__PK__KEGG | 27 | 0.074 | 0.296 | Up | 0.084 | 0.127 | 0.014 | 0.029 |
| ec00966__PK__KEGG | 3 | 0.333 | 0.333 | Down | 0.085 | 0.127 | 0.027 | 0.044 |
| ec00140__PK__KEGG | 3 | 0.333 | 0.333 | Down | 0.086 | 0.127 | 0.025 | 0.042 |
| ec00540__PK__KEGG | 11 | 0.091 | 0.364 | Up | 0.086 | 0.127 | 0.077 | 0.094 |
| ec00300__PK__KEGG | 19 | 0.158 | 0.211 | Up | 0.088 | 0.128 | 0.021 | 0.039 |
| ec00622__PK__KEGG | 4 | 0.250 | 0.500 | Up | 0.092 | 0.131 | 0.009 | 0.023 |
| ec00231__PK__KEGG | 11 | 0.091 | 0.364 | Up | 0.093 | 0.131 | 0.057 | 0.083 |
| ec00930__PK__KEGG | 7 | 0.143 | 0.429 | Up | 0.098 | 0.136 | 0.105 | 0.125 |
| ec00790__PK__KEGG | 9 | 0.222 | 0.222 | Down | 0.100 | 0.137 | 0.004 | 0.017 |
| ec00770__PK__KEGG | 8 | 0.000 | 0.250 | Up | 0.102 | 0.137 | 0.124 | 0.143 |
| ec00904__PK__KEGG | 12 | 0.167 | 0.333 | Up | 0.104 | 0.137 | 0.024 | 0.042 |
| ec00071__PK__KEGG | 18 | 0.278 | 0.333 | Up | 0.105 | 0.137 | 0.022 | 0.040 |
| ec00281__PK__KEGG | 4 | 0.250 | 0.500 | Up | 0.105 | 0.137 | 0.067 | 0.087 |
| ec00670__PK__KEGG | 7 | 0.000 | 0.429 | Up | 0.105 | 0.137 | 0.138 | 0.156 |
| ec00642__PK__KEGG | 13 | 0.154 | 0.308 | Up | 0.107 | 0.137 | 0.067 | 0.087 |
| ec00785__PK__KEGG | 2 | 0.000 | 0.500 | Up | 0.110 | 0.140 | 0.166 | 0.185 |
| ec00640__PK__KEGG | 17 | 0.118 | 0.294 | Up | 0.145 | 0.181 | 0.008 | 0.022 |
| ec00364__PK__KEGG | 6 | 0.167 | 0.333 | Up | 0.146 | 0.181 | 0.111 | 0.130 |
| ec00830__PK__KEGG | 5 | 0.200 | 0.200 | Down | 0.149 | 0.183 | 0.022 | 0.040 |
| ec00510__PK__KEGG | 3 | 0.000 | 0.333 | Up | 0.156 | 0.187 | 0.228 | 0.246 |
| ec00620__PK__KEGG | 23 | 0.174 | 0.174 | Up | 0.158 | 0.187 | 0.009 | 0.023 |
| ec00563__PK__KEGG | 7 | 0.000 | 0.429 | Up | 0.158 | 0.187 | 0.187 | 0.205 |
| ec00051__PK__KEGG | 20 | 0.150 | 0.150 | Down | 0.171 | 0.201 | 0.016 | 0.031 |
| ec00040__PK__KEGG | 6 | 0.000 | 0.333 | Up | 0.187 | 0.217 | 0.329 | 0.341 |
| ec00960__PK__KEGG | 18 | 0.167 | 0.222 | Up | 0.229 | 0.262 | 0.063 | 0.087 |
| ec00908__PK__KEGG | 2 | 0.000 | 0.500 | Up | 0.233 | 0.264 | 0.074 | 0.092 |
| ec00363__PK__KEGG | 6 | 0.167 | 0.167 | Down | 0.237 | 0.266 | 0.034 | 0.052 |
| ec00061__PK__KEGG | 9 | 0.222 | 0.222 | Up | 0.262 | 0.291 | 0.079 | 0.094 |
| ec01056__PK__KEGG | 3 | 0.000 | 0.333 | Up | 0.284 | 0.312 | 0.418 | 0.426 |
| ec00500__PK__KEGG | 5 | 0.200 | 0.200 | Down | 0.297 | 0.323 | 0.127 | 0.145 |
| ec00760__PK__KEGG | 12 | 0.083 | 0.250 | Up | 0.300 | 0.324 | 0.153 | 0.172 |
| ec00633__PK__KEGG | 4 | 0.000 | 0.500 | Up | 0.308 | 0.329 | 0.283 | 0.299 |
| ec00400__PK__KEGG | 8 | 0.000 | 0.250 | Up | 0.315 | 0.333 | 0.461 | 0.465 |
| ec00410__PK__KEGG | 4 | 0.000 | 0.250 | Down | 0.350 | 0.367 | 0.074 | 0.092 |
| ec00750__PK__KEGG | 2 | 0.000 | 0.000 | Up | 0.455 | 0.472 | 0.406 | 0.418 |
| ec00780__PK__KEGG | 13 | 0.154 | 0.077 | Up | 0.511 | 0.526 | 0.194 | 0.212 |
| ec00052__PK__KEGG | 8 | 0.125 | 0.125 | Down | 0.580 | 0.591 | 0.281 | 0.299 |
| ec00520__PK__KEGG | 21 | 0.095 | 0.143 | Down | 0.586 | 0.591 | 0.303 | 0.318 |
| ec00521__PK__KEGG | 5 | 0.000 | 0.000 | Down | 0.606 | 0.606 | 0.840 | 0.840 |
Also test using limma’s camera
kable(keg_cam, digits = 3)
| NGenes | Correlation | Direction | PValue | FDR | |
|---|---|---|---|---|---|
| ec00710__PK__KEGG | 10 | 0.175 | Down | 0.054 | 0.882 |
| ec00250__PK__KEGG | 12 | 0.040 | Down | 0.065 | 0.882 |
| ec00600__PK__KEGG | 11 | 0.059 | Up | 0.074 | 0.882 |
| ec00650__PK__KEGG | 18 | 0.043 | Up | 0.107 | 0.882 |
| ec00010__PK__KEGG | 25 | 0.126 | Down | 0.128 | 0.882 |
| ec00440__PK__KEGG | 4 | 0.201 | Down | 0.137 | 0.882 |
| ec00920__PK__KEGG | 4 | 0.221 | Up | 0.171 | 0.882 |
| ec00280__PK__KEGG | 8 | 0.000 | Up | 0.173 | 0.882 |
| ec00030__PK__KEGG | 14 | 0.097 | Down | 0.173 | 0.882 |
| ec00562__PK__KEGG | 18 | 0.052 | Down | 0.190 | 0.882 |
| ec00910__PK__KEGG | 6 | -0.038 | Down | 0.198 | 0.882 |
| ec00351__PK__KEGG | 1 | NA | Up | 0.204 | 0.882 |
| ec00983__PK__KEGG | 15 | 0.108 | Down | 0.210 | 0.882 |
| ec00020__PK__KEGG | 18 | 0.082 | Up | 0.216 | 0.882 |
| ec00660__PK__KEGG | 3 | 0.064 | Up | 0.219 | 0.882 |
| ec00601__PK__KEGG | 1 | NA | Up | 0.230 | 0.882 |
| ec00944__PK__KEGG | 1 | NA | Up | 0.230 | 0.882 |
| ec00522__PK__KEGG | 1 | NA | Up | 0.230 | 0.882 |
| ec00513__PK__KEGG | 1 | NA | Up | 0.230 | 0.882 |
| ec00603__PK__KEGG | 1 | NA | Up | 0.230 | 0.882 |
| ec00604__PK__KEGG | 1 | NA | Up | 0.230 | 0.882 |
| ec00512__PK__KEGG | 1 | NA | Up | 0.230 | 0.882 |
| ec00900__PK__KEGG | 26 | 0.099 | Up | 0.231 | 0.882 |
| ec00720__PK__KEGG | 17 | 0.056 | Up | 0.234 | 0.882 |
| ec00730__PK__KEGG | 14 | 0.029 | Up | 0.239 | 0.882 |
| ec00260__PK__KEGG | 16 | 0.048 | Up | 0.249 | 0.882 |
| ec00361__PK__KEGG | 6 | 0.029 | Up | 0.256 | 0.882 |
| ec00590__PK__KEGG | 7 | 0.040 | Down | 0.284 | 0.882 |
| ec00965__PK__KEGG | 12 | 0.093 | Up | 0.288 | 0.882 |
| ec00362__PK__KEGG | 19 | 0.010 | Up | 0.296 | 0.882 |
| ec00510__PK__KEGG | 3 | -0.038 | Up | 0.297 | 0.882 |
| ec00561__PK__KEGG | 15 | 0.020 | Up | 0.305 | 0.882 |
| ec00040__PK__KEGG | 6 | -0.035 | Up | 0.308 | 0.882 |
| ec00062__PK__KEGG | 6 | 0.067 | Up | 0.308 | 0.882 |
| ec00670__PK__KEGG | 7 | 0.114 | Up | 0.309 | 0.882 |
| ec00785__PK__KEGG | 2 | -0.456 | Up | 0.311 | 0.882 |
| ec00770__PK__KEGG | 8 | 0.077 | Up | 0.327 | 0.882 |
| ec00625__PK__KEGG | 4 | -0.116 | Down | 0.330 | 0.882 |
| ec00930__PK__KEGG | 7 | -0.013 | Up | 0.333 | 0.882 |
| ec00565__PK__KEGG | 24 | 0.063 | Up | 0.337 | 0.882 |
| ec00540__PK__KEGG | 11 | 0.073 | Up | 0.356 | 0.882 |
| ec00623__PK__KEGG | 17 | 0.048 | Up | 0.357 | 0.882 |
| ec01056__PK__KEGG | 3 | -0.091 | Up | 0.365 | 0.882 |
| ec00563__PK__KEGG | 7 | 0.116 | Up | 0.373 | 0.882 |
| ec00860__PK__KEGG | 50 | 0.044 | Up | 0.395 | 0.882 |
| ec00591__PK__KEGG | 7 | -0.043 | Down | 0.403 | 0.882 |
| ec00400__PK__KEGG | 8 | -0.031 | Up | 0.427 | 0.882 |
| ec00740__PK__KEGG | 8 | 0.088 | Up | 0.435 | 0.882 |
| ec00380__PK__KEGG | 61 | 0.026 | Up | 0.436 | 0.882 |
| ec00231__PK__KEGG | 11 | 0.006 | Up | 0.438 | 0.882 |
| ec00364__PK__KEGG | 6 | -0.048 | Up | 0.453 | 0.882 |
| ec00982__PK__KEGG | 3 | -0.186 | Down | 0.461 | 0.882 |
| ec00942__PK__KEGG | 46 | 0.066 | Up | 0.472 | 0.882 |
| ec00642__PK__KEGG | 13 | 0.042 | Up | 0.479 | 0.882 |
| ec00633__PK__KEGG | 4 | 0.271 | Up | 0.484 | 0.882 |
| ec00903__PK__KEGG | 16 | 0.015 | Up | 0.495 | 0.882 |
| ec00906__PK__KEGG | 13 | 0.077 | Up | 0.497 | 0.882 |
| ec00281__PK__KEGG | 4 | -0.034 | Up | 0.507 | 0.882 |
| ec00966__PK__KEGG | 3 | -0.138 | Down | 0.515 | 0.882 |
| ec00140__PK__KEGG | 3 | -0.138 | Down | 0.515 | 0.882 |
| ec00626__PK__KEGG | 13 | 0.027 | Up | 0.515 | 0.882 |
| ec00564__PK__KEGG | 53 | 0.046 | Up | 0.518 | 0.882 |
| ec00053__PK__KEGG | 7 | -0.010 | Up | 0.527 | 0.882 |
| ec00253__PK__KEGG | 51 | 0.042 | Up | 0.550 | 0.882 |
| ec00760__PK__KEGG | 12 | 0.155 | Up | 0.552 | 0.882 |
| ec00630__PK__KEGG | 9 | 0.063 | Up | 0.556 | 0.882 |
| ec01057__PK__KEGG | 42 | 0.053 | Up | 0.559 | 0.882 |
| ec00750__PK__KEGG | 2 | 0.114 | Up | 0.560 | 0.882 |
| ec00981__PK__KEGG | 38 | 0.057 | Up | 0.562 | 0.882 |
| ec00970__PK__KEGG | 41 | 0.062 | Down | 0.572 | 0.882 |
| ec00230__PK__KEGG | 78 | 0.031 | Down | 0.587 | 0.882 |
| ec00627__PK__KEGG | 61 | 0.060 | Up | 0.609 | 0.882 |
| ec00340__PK__KEGG | 46 | 0.059 | Up | 0.610 | 0.882 |
| ec00940__PK__KEGG | 48 | 0.062 | Up | 0.623 | 0.882 |
| ec00904__PK__KEGG | 12 | 0.058 | Up | 0.624 | 0.882 |
| ec00330__PK__KEGG | 27 | 0.032 | Up | 0.633 | 0.882 |
| ec00350__PK__KEGG | 50 | 0.047 | Up | 0.648 | 0.882 |
| ec00950__PK__KEGG | 48 | 0.053 | Up | 0.649 | 0.882 |
| ec00521__PK__KEGG | 5 | 0.123 | Down | 0.654 | 0.882 |
| ec00360__PK__KEGG | 49 | 0.053 | Up | 0.671 | 0.882 |
| ec01051__PK__KEGG | 36 | 0.058 | Up | 0.672 | 0.882 |
| ec00061__PK__KEGG | 9 | 0.175 | Up | 0.681 | 0.882 |
| ec00071__PK__KEGG | 18 | 0.031 | Up | 0.687 | 0.882 |
| ec00450__PK__KEGG | 41 | 0.061 | Up | 0.700 | 0.882 |
| ec00624__PK__KEGG | 36 | 0.050 | Up | 0.701 | 0.882 |
| ec00830__PK__KEGG | 5 | 0.011 | Down | 0.715 | 0.882 |
| ec00941__PK__KEGG | 36 | 0.055 | Up | 0.715 | 0.882 |
| ec00945__PK__KEGG | 36 | 0.055 | Up | 0.715 | 0.882 |
| ec00908__PK__KEGG | 2 | 0.056 | Up | 0.723 | 0.882 |
| ec00300__PK__KEGG | 19 | 0.007 | Up | 0.728 | 0.882 |
| ec00310__PK__KEGG | 40 | 0.023 | Up | 0.765 | 0.903 |
| ec00500__PK__KEGG | 5 | 0.069 | Down | 0.770 | 0.903 |
| ec00480__PK__KEGG | 25 | 0.052 | Up | 0.770 | 0.903 |
| ec00960__PK__KEGG | 18 | 0.058 | Up | 0.782 | 0.907 |
| ec00240__PK__KEGG | 72 | 0.021 | Up | 0.813 | 0.918 |
| ec00130__PK__KEGG | 40 | 0.048 | Up | 0.814 | 0.918 |
| ec00640__PK__KEGG | 17 | 0.029 | Up | 0.820 | 0.918 |
| ec00780__PK__KEGG | 13 | 0.044 | Up | 0.825 | 0.918 |
| ec00622__PK__KEGG | 4 | -0.120 | Up | 0.838 | 0.923 |
| ec00680__PK__KEGG | 24 | 0.019 | Up | 0.867 | 0.926 |
| ec00051__PK__KEGG | 20 | 0.028 | Down | 0.870 | 0.926 |
| ec00270__PK__KEGG | 49 | 0.035 | Up | 0.873 | 0.926 |
| ec00520__PK__KEGG | 21 | 0.048 | Down | 0.875 | 0.926 |
| ec00363__PK__KEGG | 6 | -0.018 | Down | 0.894 | 0.937 |
| ec00790__PK__KEGG | 9 | 0.041 | Down | 0.915 | 0.937 |
| ec00410__PK__KEGG | 4 | 0.037 | Down | 0.919 | 0.937 |
| ec00620__PK__KEGG | 23 | 0.059 | Up | 0.920 | 0.937 |
| ec00052__PK__KEGG | 8 | 0.043 | Down | 0.934 | 0.938 |
| ec00592__PK__KEGG | 9 | -0.043 | Down | 0.938 | 0.938 |
We now test using roast and camera for deregulation of gene sets obtained from the papers:
Daily, J. P., D. Scanfeld, N. Pochet, K. Le Roch, D. Plouffe, M. Kamal, O. Sarr, et al. 2007. “Distinct Physiological States of Plasmodium Falciparum in Malaria-Infected Patients.” Nature 450 (7172): 1091–95.
Shock, Jennifer L., Kael F. Fischer, and Joseph L. DeRisi. 2007. “Whole-Genome Analysis of mRNA Decay in Plasmodium Falciparum Reveals a Global Lengthening of mRNA Half-Life during the Intra-Erythrocytic Development Cycle.” Genome Biology 8 (7): R134.
setwd(wd)
# Load gene lists from Daily et al and Shock et al
daily_figure2 <- fread("./data/daily_expression_figure2.csv", data.table = FALSE, header = TRUE)
JLshock <- c("PF3D7_0320800", "PF3D7_0410400", "PF3D7_0507600", "PF3D7_0520300", "PF3D7_0720000", "PF3D7_0811300", "PF3D7_0819900", "PF3D7_0909400", "PF3D7_0909900",
"PF3D7_1006100", "PF3D7_1032100", "PF3D7_1103800", "PF3D7_1106300", "PF3D7_1107000", "PF3D7_1124400", "PF3D7_1128600", "PF3D7_1209200", "PF3D7_1224300",
"PF3D7_1235300", "PF3D7_1307000", "PF3D7_1308900", "PF3D7_1325000", "PF3D7_1340100", "PF3D7_1364500", "PF3D7_1427800", "PF3D7_1443300", "PF3D7_1443500",
"PF3D7_1449700", "PF3D7_0519500")
# Load entrex geneID mappings
entrez_geneID_mappings <- fread("./data/geneID_mappings.txt", data.table = FALSE, stringsAsFactors = FALSE)
upcluster2 <- daily_figure2$Gene[daily_figure2$`Up regulated in Cluster 2?` == "Y"]
upcluster1 <- daily_figure2$Gene[daily_figure2$`Up regulated in Cluster 2?` == "N"]
glycolisis <- daily_figure2$Gene[daily_figure2$type == "Glycolisis"]
tricarboxylic <- daily_figure2$Gene[daily_figure2$type == "Tricarboxylic acid cycle"]
fatty_acid <- daily_figure2$Gene[daily_figure2$type == "Fatty acid metabolism"]
upcluster2 <- as.vector(geneID_mappings$current[geneID_mappings$old %in% upcluster2])
upcluster1 <- as.vector(geneID_mappings$current[geneID_mappings$old %in% upcluster1])
glycolisis <- as.vector(geneID_mappings$current[geneID_mappings$old %in% glycolisis])
tricarboxylic <- as.vector(geneID_mappings$current[geneID_mappings$old %in% tricarboxylic])
fatty_acid <- as.vector(geneID_mappings$current[geneID_mappings$old %in% fatty_acid])
indices <- ids2indices(list(up_in_starvation = upcluster1, up_int_vitro = upcluster2, glycolisis = glycolisis, tricarboxylic = tricarboxylic, fatty_acid = fatty_acid,
mRNA_degradation = JLshock), rownames(v2$E))
mroast(v2, index = indices, design = modRUV, contrast = 2, nrot = 10000, set.statistic = "floormean")
## NGenes PropDown PropUp Direction PValue FDR PValue.Mixed FDR.Mixed
## up_int_vitro 12 0.8333333 0.00000000 Down 0.01129887 0.02812219 0.01249875 0.01493851
## glycolisis 19 0.5789474 0.05263158 Down 0.01309869 0.02812219 0.01009899 0.01493851
## mRNA_degradation 29 0.2758621 0.06896552 Down 0.01459854 0.02812219 0.00769923 0.01493851
## tricarboxylic 11 0.1818182 0.36363636 Up 0.01879812 0.02812219 0.00129987 0.00749925
## up_in_starvation 33 0.1818182 0.21212121 Up 0.06249375 0.07493251 0.00929907 0.01493851
## fatty_acid 17 0.1764706 0.11764706 Up 0.12558744 0.12558744 0.07129287 0.07129287
camera(v2, index = indices, design = modRUV, contrast = 2)
## NGenes Correlation Direction PValue FDR
## up_int_vitro 12 0.52478121 Down 0.08926728 0.3726012
## glycolisis 19 0.21525215 Down 0.12420039 0.3726012
## mRNA_degradation 29 0.05546379 Down 0.23644819 0.4728964
## tricarboxylic 11 0.07171539 Up 0.37832832 0.4837847
## up_in_starvation 33 0.07428553 Up 0.46672227 0.4837847
## fatty_acid 17 0.06532833 Up 0.48378475 0.4837847
setwd(wd)
sessionInfo()
## R version 3.2.0 (2015-04-16)
## Platform: x86_64-apple-darwin15.4.0 (64-bit)
## Running under: OS X 10.11.6 (unknown)
##
## locale:
## [1] en_AU.UTF-8/en_AU.UTF-8/en_AU.UTF-8/C/en_AU.UTF-8/en_AU.UTF-8
##
## attached base packages:
## [1] grid stats4 parallel stats graphics grDevices utils datasets methods base
##
## other attached packages:
## [1] pheatmap_1.0.8 knitr_1.15.1 stringr_1.1.0 dplyr_0.5.0 data.table_1.10.0
## [6] VennDiagram_1.6.17 futile.logger_1.4.3 RColorBrewer_1.1-2 EDASeq_2.4.1 ShortRead_1.28.0
## [11] GenomicAlignments_1.6.3 SummarizedExperiment_1.0.2 Rsamtools_1.22.0 GenomicRanges_1.22.4 GenomeInfoDb_1.6.3
## [16] Biostrings_2.38.4 XVector_0.10.0 IRanges_2.4.8 S4Vectors_0.8.11 BiocParallel_1.4.3
## [21] Biobase_2.30.0 BiocGenerics_0.16.1 reshape2_1.4.2 ggplot2_2.2.1 ruv_0.9.6
## [26] quadprog_1.5-5 edgeR_3.12.1 limma_3.26.9
##
## loaded via a namespace (and not attached):
## [1] splines_3.2.0 R.utils_2.5.0 assertthat_0.1 statmod_1.4.27 highr_0.6 aroma.light_3.0.0
## [7] latticeExtra_0.6-28 yaml_2.1.14 RSQLite_1.1-1 backports_1.0.4 lattice_0.20-31 digest_0.6.11
## [13] colorspace_1.3-2 htmltools_0.3.5 Matrix_1.2-0 R.oo_1.21.0 plyr_1.8.4 XML_3.98-1.5
## [19] biomaRt_2.26.1 genefilter_1.52.1 zlibbioc_1.16.0 xtable_1.8-2 scales_0.4.1 tibble_1.2
## [25] annotate_1.48.0 GenomicFeatures_1.22.13 lazyeval_0.2.0 survival_2.40-1 magrittr_1.5 memoise_1.0.0
## [31] evaluate_0.10 R.methodsS3_1.7.1 hwriter_1.3.2 tools_3.2.0 formatR_1.4 matrixStats_0.51.0
## [37] munsell_0.4.3 AnnotationDbi_1.32.3 lambda.r_1.1.9 DESeq_1.22.1 RCurl_1.95-4.8 bitops_1.0-6
## [43] labeling_0.3 rmarkdown_1.3 gtable_0.2.0 DBI_0.5-1 R6_2.2.0 rtracklayer_1.30.4
## [49] rprojroot_1.1 futile.options_1.0.0 stringi_1.1.2 Rcpp_0.12.8 geneplotter_1.48.0